Nitric oxide synthase (nNOS/eNOS/iNOS)
Cofactors used
Clinical / pharmacological. NO -> cGMP; nitrate and PDE5-inhibitor axis
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Arginine + O2 + NADPH -> nitric oxide + L-citrulline
Converts Arginine O2 NADPH into Nitric oxide L-citrulline
› Notes
NO activates soluble guanylate cyclase -> cGMP -> smooth-muscle relaxation; the mechanism exploited by nitrates and by PDE5 inhibitors.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Recombinant ubbR promoter enables highly efficient tamoxifen-inducible Cre recombination in embryonic and adult zebrafish.
Bakūnaitė E, Gečaitė E, Žemalytė S, Denkovskij J, Lazutka J, Balciunas D. · 2026-09-01
cited 2× open access unreviewed -
2
GAPDH nuclear signaling regulates neutrophil migration and inflammatory skin responses
· 2026-08-11
open access unreviewed -
3
Dihydropyrimidine dehydrogenase modulates immune response to checkpoint inhibition in mismatch repair deficient/microsatellite instability-high colorectal cancer.
Soni S, Battaglin F, Castanon S, Yang Y, Smbatyan G, Torres Gonzalez L, Ho Lo J, Mittal P, Gonzalez E, Baugh … · 2026-08-17
open access unreviewed -
4
Nitric oxide drives proteomic diversity through alternative splicing.
Schindler JC, Seth P, Hausladen A, Chan ER, Yang J, Qin J, Qian Z, Seth D, Lundberg K, Luna JM, Premont RT, S… · 2026-05-21
unreviewed -
5
Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.
Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gaba… · 2026-05-30
unreviewed -
6
Amino Acid-Fatty Acid Profile as a Novel Predictive Method in the Assessment of Diagnosis and Treatment Efficacy of Anxiety-Related Disorders and Mood Disorders.
Kowalczyk M, Aebisher D, Szpara J, Czech S, Kowalczyk E, Majsterek I, Bartusik-Aebisher D, Henrykowska G. · 2026-05-23
open access unreviewed -
7
The role of constitutive nitric-oxide synthase in regulation of IKKα after ultraviolet irradiation.
Zhou Y, Tong L, Bastidas B, Liu T, Wright M, Zhou M, Wu S. · 2026-01-05
unreviewed -
8
Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in <i>KRAS<sup>G12C</sup></i> -mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors.
Ozakinci H, Desai B, Kalos D, Chen DT, Henry M, Solanki H, Boyle TA, Trejo Bittar HE, Nazario GS, Haura EB, M… · 2026-04-26
cited 1× open access unreviewed -
9
Endothelial Nitric Oxide Synthase-Dependent Mechanism of Hydroxyurea-Induced S-Phase Arrest in Erythroid Cells.
Dragojević T, Đikić D, Mojsilović S, Lazarević M, Milenković D, Ajtić OM, Živković E, Diklić M, Subotički T, … · 2026-03-31
open access unreviewed -
10
Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.
Ma J, Bhardwaj V, Lobie PE, Pandey V. · 2026-03-28
cited 4× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.