Nitric oxide synthase (nNOS/eNOS/iNOS)
Cofactors used
Clinical / pharmacological. NO -> cGMP; nitrate and PDE5-inhibitor axis
What it does, reaction by reaction
Other Neurotransmitter Synthesis Amino Acid & Nitrogen Metabolism · Cytosol
L-Arginine + O2 + NADPH -> nitric oxide + L-citrulline
Converts Arginine O2 NADPH into Nitric oxide L-citrulline
› Notes
NO activates soluble guanylate cyclase -> cGMP -> smooth-muscle relaxation; the mechanism exploited by nitrates and by PDE5 inhibitors.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Nitric oxide drives proteomic diversity through alternative splicing.
Schindler JC, Seth P, Hausladen A, Chan ER, Yang J, Qin J, Qian Z, Seth D, Lundberg K, Luna JM, Premont RT, S… · 2026-05-21
unreviewed -
2
Unilateral Adrenalectomy, and the Stable Pentadecapeptide BPC 157 as Therapy in Rats-A Cytoprotection Approach.
Smoday IM, Vukovic V, Oroz K, Vranes H, Kalogjera L, Gamulin O, Vlainic J, Milavic M, Sikiric S, Nikolac Gaba… · 2026-05-30
unreviewed -
3
Amino Acid-Fatty Acid Profile as a Novel Predictive Method in the Assessment of Diagnosis and Treatment Efficacy of Anxiety-Related Disorders and Mood Disorders.
Kowalczyk M, Aebisher D, Szpara J, Czech S, Kowalczyk E, Majsterek I, Bartusik-Aebisher D, Henrykowska G. · 2026-05-23
open access unreviewed -
4
The role of constitutive nitric-oxide synthase in regulation of IKKα after ultraviolet irradiation.
Zhou Y, Tong L, Bastidas B, Liu T, Wright M, Zhou M, Wu S. · 2026-01-05
unreviewed -
5
Pre-clinical efficacy of trastuzumab deruxtecan plus sotorasib in <i>KRAS<sup>G12C</sup></i> -mutant non-small cell lung cancer and exploratory HER2 profiling in human tumors.
Ozakinci H, Desai B, Kalos D, Chen DT, Henry M, Solanki H, Boyle TA, Trejo Bittar HE, Nazario GS, Haura EB, M… · 2026-04-26
open access unreviewed -
6
Endothelial Nitric Oxide Synthase-Dependent Mechanism of Hydroxyurea-Induced S-Phase Arrest in Erythroid Cells.
Dragojević T, Đikić D, Mojsilović S, Lazarević M, Milenković D, Ajtić OM, Živković E, Diklić M, Subotički T, … · 2026-03-31
open access unreviewed -
7
Metabolic plasticity in pancreatic ductal adenocarcinoma progression and response to treatment.
Ma J, Bhardwaj V, Lobie PE, Pandey V. · 2026-03-28
cited 2× open access unreviewed -
8
Adult life outcomes for adolescents 12.4 years after dialectical behavior therapy - a randomized clinical trial.
Mehlum L, Dibaj IS, Haga E, Helle SE, Morken KTE, Klungsøyr O, Tørmoen AJ. · 2026-01-16
cited 1× open access unreviewed -
9
Metformin exacerbates diabetic amyotrophy via oxidative stress and gut microbiota alterations.
Wang H, Cao Z, Yousaf W, Haseeb A, Wang Z, Zheng J. · 2026-04-13
open access unreviewed -
10
Redox-associated gene and microRNA signatures in degenerative intervertebral disc disease.
Strojny D, Szwej K, Staszkiewicz R, Sobański D, Gogol P, Lehotská M, Majchrowicz B, Grabarek BO. · 2026-01-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.