Methylenetetrahydrofolate reductase (MTHFR)
Cofactors used
Clinical / pharmacological. MTHFR variants: hyperhomocysteinaemia
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
5,10-Methylene-THF + NADPH + H⁺ → 5-methyl-THF + NADP⁺
Converts 5,10-Methylene-THF NADPH H+ into 5-Methyl-THF NADP+
› Notes
Methylenetetrahydrofolate reductase (MTHFR) uses FAD as a prosthetic group and NADPH-derived reducing power to generate 5-methyl-THF. This is an effectively irreversible, regulated branch-point reaction that commits one-carbon units to methionine regeneration rather than nucleotide synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Pediatric Spinal Cord Stroke: Clinical Presentation, MRI Features, and Suspected Mechanisms.
Acero-Garces DO, Gordon-Lipkin E, Lin DDM, Sun LR, Felling RJ, Gailloud P, Elrick MJ, Pardo CA, Chen H. · 2026-09-30
unreviewed -
2
Mapping current evidence and knowledge gaps in gestational diabetes mellitus in Vietnam and Vietnamese diaspora: a scoping review.
Tran CTN, Popovich DG, Lachat C, Eri R, Tran HTM, Truong T. · 2026-09-28
open access unreviewed -
3
Homocystinuria symptomatology collected through an international patient-report data program as a source for natural history data.
Parke B, Bartke D, Beek G, Talebizadeh Z, Chapman KA, Baker J, Thomas JA. · 2026-09-11
open access unreviewed -
4
Analysis of <i>MTHFR</i> C677T polymorphism in elderly Iranian women from Bushehr.
Kaviani M, Hemati H, Asadifard E, Hokmabadi M, Bidkhori M, Sharifi F, Abiri A, Ghahghaei A, Fahimfar N, Hasan… · 2026-09-16
unreviewed -
5
A preeclampsia prediction model incorporating methylenetetrahydrofolate reductase, vitamin D receptor, and uterine artery pulsatility index.
Xu M, Yang G, Zhong X, Jin Z, Tang M, Xiao Y, Guo Y. · 2026-09-11
unreviewed -
6
Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients.
Fang M, Xia T, Yin Y. · 2026-08-21
open access unreviewed -
7
Association of elevated homocysteine levels with renal pathology and function in patients with IgA nephropathy: a single-center retrospective study.
Lin L, Yu B, Wu M, Su Y, Cui Y, Li C, Zhang Z, Teng J. · 2026-08-18
open access unreviewed -
8
Comprehensive safety assessment of novel dicholine folate vitamin.
Jonaitis T, Ulmann M, Wiesler G, Lukasik KV. · 2026-07-15
open access unreviewed -
9
Individualized pharmacogenomics for depressive episodes: A narrative review.
Haddad M, Dieckmann LHJ, Hoss GRW, de Jesus Mari J, Young AH, Juruena MF. · 2026-07-13
unreviewed -
10
Molecular epidemiology of the MTHFR C677T polymorphism and its association with type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital.
Kassahun Berie G, Dagnaw M, Indracanti M, Dejen M, Berhane N. · 2026-03-16
cited 1× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.