Methylenetetrahydrofolate reductase (MTHFR)
Cofactors used
Clinical / pharmacological. MTHFR variants: hyperhomocysteinaemia
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
5,10-Methylene-THF + NADPH + H⁺ → 5-methyl-THF + NADP⁺
Converts 5,10-Methylene-THF NADPH H+ into 5-Methyl-THF NADP+
› Notes
Methylenetetrahydrofolate reductase (MTHFR) uses FAD as a prosthetic group and NADPH-derived reducing power to generate 5-methyl-THF. This is an effectively irreversible, regulated branch-point reaction that commits one-carbon units to methionine regeneration rather than nucleotide synthesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Molecular epidemiology of the MTHFR C677T polymorphism and its association with type 2 diabetes mellitus at the University of Gondar Comprehensive Specialized Hospital.
Kassahun Berie G, Dagnaw M, Indracanti M, Dejen M, Berhane N. · 2026-03-16
cited 1× unreviewed -
2
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
open access unreviewed -
3
Premature coronary artery disease in women: sex-specific risk factors, pathogenetic mechanisms and clinical implications.
Li F, Hong D, Yang M, Pang Z, Xi H, Zhang Q, Li C, Mo L, Peng L. · 2026-01-30
open access unreviewed -
4
ICR-LAMP: A one-pot isothermal assay enabled by transient spatial separation and dynamic ICR for high-specificity SNP genotyping.
Dong J, Shi J, Zhao J, Chen X, Zhan G, Du F, Cui X, Wang W, Ding S, Tang Z. · 2026-06-08
unreviewed -
5
Physiological and transcriptomic insights deciphering cAMP-induced oxidative stress tolerance of antagonistic yeast Sporidiobolus pararoseus Y16.
Zhao Y, Zhang X, Dhanasekaran S, Godana EA, Li J, Zhang Z, Zhao L, Zhang H. · 2026-05-20
unreviewed -
6
Global DNA methylation and MTHFR gene polymorphism status of ghanaians with early-onset intracerebral hemorrhage: implications for future interventions.
Opare-Addo PA, Sarfo FS, Ovbiagele B, Aikins M, Asare-Bediako S, Boateng R, Olympio Mensah OS, Adu-Gyamfi AA,… · 2026-09-01
unreviewed -
7
Plasma homocysteine and Endothelin-1 dysregulation: Insights into retinal endothelial dysfunction.
Msa M. · 2026-06-12
unreviewed -
8
MicroRNA expression profiles in abdominal aortic aneurysms: A systematic review of potential diagnostic and prognostic biomarkers.
Eini P, Eini P, Serpoush H, Rezayee M, Tremblay J. · 2026-05-07
open access unreviewed -
9
Comparative Analysis of Treatment With Folate Forms in Clinical Practice.
Skavinska O, Rossokha Z, Stefanyshyn V, Hrebeniuk O, Fishchuk L, Quadros EV, Gorovenko N. · 2026-09-01
unreviewed -
10
Sex-Specific Associations Between MTHFR, PPARG and ADRB3 Polymorphisms, Habitual Nutrient Intake and Metabolic Risk in Obesity: A Cross-Sectional Single-Centre Study.
Lapik IA, Tarmaeva IY, Nikityuk DB. · 2026-08-04
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.