Heme oxygenase (HO-1 inducible; HO-2 constitutive)
Cofactors used
Clinical / pharmacological. Produces biliverdin, CO and Fe2+; rate-limiting for heme catabolism
What it does, reaction by reaction
Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut
Heme + O₂ + NADPH + H⁺ → biliverdin IXα + Fe²⁺/³⁺ + CO + NADP⁺ + H₂O
Converts Heme O2 NADPH H+ into Biliverdin IX-alpha Fe2+/3+ CO NADP+ H2O
› Notes
Heme oxygenase (HO-1 inducible; HO-2 constitutive) cleaves the α-methene bridge of heme in macrophage endoplasmic reticulum. It requires molecular oxygen, NADPH, and electrons delivered by NADPH–cytochrome P450 reductase; this is the rate-limiting, committed, and irreversible step of heme catabolism, and it liberates iron for recycling plus carbon monoxide.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Mailuo Shutong pills alleviate limb swelling in femoral fracture rats by orchestrating mitophagic clearance and ferroptotic suppression.
Zhuang X, Mo T, Ji W, Wang B, Yao R, Zhao W, Yang L, Xu Y, Tan Y, Yao J, Sun C, Cheng G. · 2026-07-20
unreviewed -
2
Trifluoro-icaritin mitigates spared nerve injury-induced neuropathic pain by upregulating spinal α7nAChR through suppressing ferroptosis.
Luo F, Zhong Y, Meng L, Chen X, Li W, Wei T, Ma H, Huang C. · 2026-07-01
unreviewed -
3
DMAMCL induces ferroptosis in neuroblastoma by targeting HMOX1 in MYCN-amplified subtypes whereas targeting STEAP3 in MYCN-nonamplified subtypes.
Ma Y, Zhang S, Zhang D, Hua Z, Li Z. · 2026-07-13
unreviewed -
4
Ethnopharmacological potential and mechanistic study of Platycodon grandiflorum stems and leaves and Lonicera japonica stems and leaves against acute lung injury.
Zhao N, Li H, Guo Y, Wu F, Wang X, Hua Y, Wei Y, Ji P, Ren J. · 2026-06-30
unreviewed -
5
Liquiritin prevents preterm labor by remodeling decidual steroid homeostasis through 11β-HSD1 inhibition.
Zhang X, Zhang W, Huang J, Zeng H, Liu W, Wu Y, Liu L, Li Q. · 2026-06-24
unreviewed -
6
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
7
Evaluating the global cellular pharmacological effects of photodynamic therapy using label-free surface-enhanced Raman spectroscopy.
Zhu Q, Zhou Q, Wang S, Yuan Y, Lu F. · 2026-06-07
unreviewed -
8
Shikonin suppresses diffuse large B-cell lymphoma progression by inducing ferritinophagy and ferroptosis <i>via</i> lncRNA ADPGK-AS1 downregulation.
Chen C, Chen X, Huang X, Xie Y, Shi P, Qian S, Chen Z. · 2026-06-15
open access unreviewed -
9
The cysteine metabolic regulation through CSE-transsulfuration pathway is essential in iron-induced oxidative damage of heart.
Zhang Y, Xin Y, Zhou J, Yang G, Li S. · 2026-06-05
open access unreviewed -
10
Polydatin alleviates adenine-induced nephropathy in mice.
Sheng T, Ma T, Jin X, Chen D, Che S, Wang J, Shen J, Shi C, Li Q, Sun Y, Chen D, Xu G. · 2026-05-31
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.