Heme oxygenase (HO-1 inducible; HO-2 constitutive)
Cofactors used
Clinical / pharmacological. Produces biliverdin, CO and Fe2+; rate-limiting for heme catabolism
What it does, reaction by reaction
Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut
Heme + O₂ + NADPH + H⁺ → biliverdin IXα + Fe²⁺/³⁺ + CO + NADP⁺ + H₂O
Converts Heme O2 NADPH H+ into Biliverdin IX-alpha Fe2+/3+ CO NADP+ H2O
› Notes
Heme oxygenase (HO-1 inducible; HO-2 constitutive) cleaves the α-methene bridge of heme in macrophage endoplasmic reticulum. It requires molecular oxygen, NADPH, and electrons delivered by NADPH–cytochrome P450 reductase; this is the rate-limiting, committed, and irreversible step of heme catabolism, and it liberates iron for recycling plus carbon monoxide.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Engineered probiotics couple photothermal cuproptosis with biomechanical disruption and immune activation.
Zhang X, Liu X, Huang K, Jin B, Ma N, Liu H, Jiang H, Wang X. · 2026-09-21
open access unreviewed -
2
A programmable spatiotemporal bioelectrical conduit promotes peripheral nerve regeneration by suppressing ferroptosis through modulation of ER-mitochondria coupling in Schwann cells.
Wang Z, Jiang A, Wang F, Yang Z, Zhong Y, Yang Y, Tan J, Han W, Li X, He X, Zhang X, Wang J, Han X, Bai D. · 2026-09-16
open access unreviewed -
3
Multienzymatic hybrid bio-heterojunction for synergistic microenvironment reprogramming and selenoprotein-activated mitochondrial bioenergetics in diabetic osseointegration.
Zhang M, Lu M, Chen Y, Ming M, Luo B, Wu Y. · 2026-09-16
open access unreviewed -
4
Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.
Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03
open access unreviewed -
5
An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis.
Cui Q, Li Y, Xie M, Liu Z, Guo Y, Zang Y, Bao J, Wu Q, Tian L, Jie Y. · 2026-09-04
open access unreviewed -
6
Quercetin-derived carbon dots-modified ZIF-8 and M2 macrophage-derived migrasomes-functionalized microenvironment-responsive nanocomposite hydrogel for osteoporotic bone defects regeneration.
Yin H, Li Y, Zhu Y, Yan Z, Han Y, Cheng F, Hu J, Ma J, Xing X, Yang C, Tian H, Chen W, Zhang Y. · 2026-08-30
open access unreviewed -
7
AIE-pharmacology-enabled organelle therapeutics for microplastic-induced asthenozoospermia.
Wen F, Zhang Y, Zhao F, Wang M, Hosea R, Chen Y, Chen X, Tang BZ, Sun F, Yu X. · 2026-08-22
unreviewed -
8
Self-powered electro-activated Mg<sub>x</sub>Fe<sub>1-x</sub>S<sub>2</sub> scaffold for gas-ion therapy in osteosarcoma suppression and bone regeneration.
Lu B, Chen Z, Yan S, Yu D, Yue X, Zhang Y, Zhang M, Guo J, Xu B, Li X, Huang H, Zhang K, Shi L, Qian X, Guo Z… · 2026-08-03
unreviewed -
9
PINK1 deficiency exacerbates age-related bone loss in association with enhanced inflammatory adipocyte differentiation.
Sung MJ, An HJ, Yeo H, Choi S, Ha MH, Jeong HY, Baek J, Sooyoung J, Lee SY, Lee S. · 2026-03-27
open access unreviewed -
10
Transcriptional circuits of the glioma microenvironment: FOSL2 as a master regulator of the pathological niche.
Zhang J, Guan C, Wang Z, Jin L, Lin Z, Wen J, Chen G, Guo P. · 2026-05-12
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.