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unreviewed

6-Phosphogluconate dehydrogenase

1 reactions · 1 pathways

Cofactors used

Mg2+ · Magnesium Mn2+ NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism · Cytosol

step 3 Irreversible

6-Phosphogluconate + NADP+ → ribulose-5-phosphate + CO2 + NADPH + H+

Converts 6-Phosphogluconate NADP+ into Ribulose-5-phosphate CO2 NADPH H+

› Notes

6-Phosphogluconate dehydrogenase requires NADP+ and a divalent cation such as Mg2+ or Mn2+. Oxidative decarboxylation yields the second NADPH; this is the second irreversible reaction of the oxidative phase.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pentose Phosphate Pathway (Oxidative and Non-oxidative phases)

Accelerated by

NADP+, 6-phosphogluconate

Inhibited by

NADPH (product/redox-state dependent)

Hormonal control

Insulin can increase lipogenic PPP enzyme expression

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    The dimensionality and somatisation correlates of ICD-11 prolonged grief disorder.

    McCusker P, Killikelly C, O'Connor MF, McBride O, Cunningham J, Murphy J, Duffy M, Shevlin M. · 2026-07-28

    unreviewed
  2. 2
    Well-being comparisons and mental health outcomes following loss: a two-wave longitudinal study.

    Schlechter P, Hoppen TH, Bonanno GA, Morina N. · 2026-07-07

    unreviewed
  3. 3
    San Wei Tan Xiang (SWTX) ameliorates depressive-like behaviors by modulating 6-phosphogluconate dehydrogenase (6PGD) activity in mice.

    Ling Y, Gu L, Feng S, Dong M, Li L, Zhang X, Zhang X, Ma R, Chen M, Tong L. · 2026-06-11

    unreviewed
  4. 4
    Perceived opportunities and risks of using deepfake technology in grief treatment: a qualitative study among Dutch bereaved people and mental health care workers.

    van Oostrum JM, Akalin D, Lenferink L. · 2026-05-26

    open access unreviewed
  5. 5
    Pooling data from studies on prolonged grief: the Multi-region Archive of Research data on Bereavement and Loss from Empirical Studies (MARBLES) project.

    Boelen PA, Baş S, Bolaséll LT, Bryant RA, Cesur-Soysal G, Eisma MC, Goodfellow B, De Keijser J, Kersting A, K… · 2026-05-26

    open access unreviewed
  6. 6
    Biological-chemical method for synthesizing <i>p</i>-menthane-3,8-diol.

    Zuo X, Zhang H, Zhang Z, Ma Y, Zhang C, Lu W. · 2026-05-12

    open access unreviewed
  7. 7
    Impact of leucine-rich diet on placenta's proteomic and metabolomic profiles of pregnant tumor-bearing rats.

    Dos Santos IF, Salgado CM, Carregari VC, Dos Santos RW, de Souza DM, Viana LR, Gomes-Marcondes MCC. · 2026-05-14

    open access unreviewed
  8. 8
    Systematic metabolic engineering of <i>Escherichia coli</i> for high-level production of pseudouridine via pathway optimization and precursor enhancement.

    Song J, Shen W, Xia Y, Zhou L, Zhou Y, Yang H, Chen X. · 2026-04-06

    open access unreviewed
  9. 9
    Grief modular group therapy: theoretical bases and pilot study of a new bereavement intervention programme in China.

    Zhou N, Tang S, Zhou J, Guo L, Junlian L, Situ B, Liu X. · 2026-04-14

    open access unreviewed
  10. 10
    Virtual rescripting after loss using deepfake technology in prolonged grief treatment: a study protocol for a multiple baseline design.

    Petkovski M, Knipschild R, Gevers T, Lenferink LIM. · 2026-04-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.