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unreviewed

6-Phosphogluconate dehydrogenase

1 reactions · 1 pathways

Cofactors used

Mg2+ · Magnesium Mn2+ NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism · Cytosol

step 3 Irreversible

6-Phosphogluconate + NADP+ → ribulose-5-phosphate + CO2 + NADPH + H+

Converts 6-Phosphogluconate NADP+ into Ribulose-5-phosphate CO2 NADPH H+

› Notes

6-Phosphogluconate dehydrogenase requires NADP+ and a divalent cation such as Mg2+ or Mn2+. Oxidative decarboxylation yields the second NADPH; this is the second irreversible reaction of the oxidative phase.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pentose Phosphate Pathway (Oxidative and Non-oxidative phases)

Accelerated by

NADP+, 6-phosphogluconate

Inhibited by

NADPH (product/redox-state dependent)

Hormonal control

Insulin can increase lipogenic PPP enzyme expression

Recent literature

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Europe PMC · fetched just now · sorted by publication date

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    Li Y, Jiao K, Chow AYM, Ng YH, Chong ESK, Cong Q, Ning J, Suen MHP. · 2026-08-24

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    Lin C, Qian W, Stelzer EM, Le HH, Wang J, Boelen PA, Killikelly C. · 2026-08-24

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    Yang Z, Wang J, Wu J, Fan Y, Ying T, Zhang H, Bai J, Wang Y, Liu P, Li G, Nie M, Tian X, Mei X, Zhang Z, Wang… · 2026-08-07

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    Hong HY, Kim EY, Woo A, Kim SY, Yang YH, Kim HE, Lee JG, Park MS. · 2026-08-03

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    Bryant RA, Shtefen I, Romanchuk O, Mykhniak O, Cresswell C, Danese A, Dyb G, Kassam-Adams N, Layne C, Ougrin … · 2026-07-28

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External claims. These come from an index outside this database and are not checked against it. Treat them as leads.