5,10-Methylene-THF
Reactions involving 5,10-Methylene-THF
Every recorded step where this molecule takes part
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5,10-Methylene-THF + NADP⁺ ⇌ 5,10-methenyl-THF + NADPH + H⁺
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5,10-Methylene-THF + dUMP → dTMP + DHF
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5,10-Methylene-THF + NADPH + H⁺ → 5-methyl-THF + NADP⁺
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L-serine + THF ⇌ glycine + 5,10-methylene-THF + H₂O
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produced Serine hydroxymethyltransferase (SHMT1/SHMT2) Deoxyribonucleotide Formation (Ribonucleo… ST-0259
THF → 5,10-methylene-THF
Showing all 5 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Deoxyribonucleotide Formation (Ribonucleoti… | → | One-Carbon Metabolism (Folate Cycle) | cross-category |
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12
open access unreviewed -
2
The impact of vitamin B12 deficiency on urinary profile of <i>de novo</i> purine synthesis intermediates: consequences of the methylfolate trap.
Krijt J, Škopová V, Sokolová J, Zikánová M, Chrastina P, Stanovský S, Kožich V. · 2026-06-24
unreviewed -
3
Glycine: The missing link between carbohydrate and xenobiotic metabolism in the maturing human hepatocyte.
Pozo Garcia V, Çobanoğlu TS, Riga K, Sharma S, Jennings P, Vos JC, Moco S. · 2026-05-28
open access unreviewed -
4
One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.
Al Qassab M, Bou Ghanem A, Hussayni Y, Kadbey R, Ratel Y, Yehya S, Zahr M, Ghadieh HE, Abi Khattar Z, Azar S,… · 2026-03-17
open access unreviewed -
5
Metabolic engineering enables <i>Escherichia coli</i> to grow on 1,3-propanediol.
Poon NY, Sinskey AJ, Zhou K. · 2025-12-22
open access unreviewed -
6
The complex link of the folate-homocysteine axis to myocardial hypertrophy and heart failure: from mechanistic exploration to clinical vision.
Wang Y, LaBapuchi, Liu M, Chen L. · 2025-09-19
cited 1× open access unreviewed -
7
Liver Mitochondrial Transcriptomic Responses to Dietary Crude Protein and Phosphorus Deficiencies and Feed Restriction in Wethers
Fernandez E, Innes D, Bottje W, Fortes M, Poppi D, Quigley S, Bond J, Hudson N. · 2026-05-31
open access unreviewed -
8
Natural Molecules for Brain Health and Resilience.
Venetsanaki V, Pardali EC, Cholevas C, Grammatikopoulou MG, Goulis DG, Theoharides TC. · 2026-05-13
open access unreviewed -
9
Genome-scale metabolic modeling uncovers cell-type specific signatures associated with APOE variants.
Uzuner Odongo D, Stephenson RA, Cheng L, Yang LG, Narayan PS, Çakır T, Thambisetty M. · 2026-05-07
open access unreviewed -
10
Amino Acid-Driven Mitochondrial Metabolic Rewiring Controls Antitumor Immunity.
Ham S, Jo MJ, Song KH, Choi BH. · 2026-05-03
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.