Shared (2 pathways) Pathway metabolite unreviewed

5,10-Methylene-THF

Pathways

Reactions involving 5,10-Methylene-THF

Every recorded step where this molecule takes part

All 5 Consumed 3 Produced 2

consumed Methylene-THF dehydrogenase (MTHFD1) One-Carbon Metabolism (Folate Cycle) ST-0162

5,10-Methylene-THF + NADP⁺ ⇌ 5,10-methenyl-THF + NADPH + H⁺
consumed Thymidylate synthase (TYMS) One-Carbon Metabolism (Folate Cycle) ST-0165

5,10-Methylene-THF + dUMP → dTMP + DHF
consumed Methylenetetrahydrofolate reductase (MTHFR) One-Carbon Metabolism (Folate Cycle) ST-0168

5,10-Methylene-THF + NADPH + H⁺ → 5-methyl-THF + NADP⁺
produced Serine hydroxymethyltransferase (SHMT1/SHMT2) One-Carbon Metabolism (Folate Cycle) ST-0161

L-serine + THF ⇌ glycine + 5,10-methylene-THF + H₂O
produced Serine hydroxymethyltransferase (SHMT1/SHMT2) Deoxyribonucleotide Formation (Ribonucleo… ST-0259

THF → 5,10-methylene-THF

Showing all 5 reactions.

Pathway junctions through this molecule

Produced in one pathway, consumed in another

1 links

Produced in		Consumed in	Link
Deoxyribonucleotide Formation (Ribonucleoti…	→	One-Carbon Metabolism (Folate Cycle)	cross-category

Recent literature

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Europe PMC · fetched just now · sorted by publication date

1
Comprehensive safety assessment of novel dicholine folate vitamin.
Jonaitis T, Ulmann M, Wiesler G, Lukasik KV. · 2026-07-15

open access unreviewed
2
Interactions between nutrition and the epigenome: how can it be harnessed for public health?
Anastasopoulou M, Dereki I, Sgourou A, Lagoumintzis G. · 2026-03-12

cited 2× open access unreviewed
3
Oligomeric defects in soybean serine hydroxymethyltransferase 8: tetramer destabilization by A149T and other variants associated with soybean cyst nematode resistance.
Samarakoon V, Buckley DP, Owuocha LF, Durie CL, Mitchum MG, Beamer LJ. · 2026-03-31

unreviewed
4
Folate: An Emerging Target in Type 2 Diabetes Mellitus and Its Complications.
Xiao X, Qin S, Jiang Z, Huo Y, Li J, Yang M. · 2026-09-17

open access unreviewed
5
Bioavailability of Nutrients from Animal-Derived Foods Versus Other Sources of Foods: A Comprehensive Literature Review.
Rudy M. · 2026-09-03

open access unreviewed
6
Antiplasmodial Compounds from Eurycoma harmandiana Pierre and Eurycoma longifolia Jack Against Drug-Resistant Plasmodium falciparum: An Integrated In Vitro and In Silico Study.
Konyanee A, Wahab HA, Kamarulzaman EE, Suhaimi AMM, Ismail AG, Chaniad P, Plirat W, Phuwajaroanpong A, Juengw… · 2026-09-04

open access unreviewed
7
Mitochondrial depolarization stabilizes the vitamin B12 chaperone MMADHC in the cytosol to increase MTR activity.
Rath SP, Li Z, Guha A, Dong F, Banerjee R, Mootha VK. · 2026-09-08

cited 1× open access unreviewed
8
Excess folate elevates formaldehyde genotoxicity in cell lines but not in mice or humans.
Mellor C, James BT, Azad S, Kosmeder EP, Purello CT, Singh M, Simon V, Cheng NW, Niedermaier J, Burgos-Barrag… · 2026-08-12

open access unreviewed
9
Personalised Nutraceutical Treatment Guided by MTHFR Genotype in Mental Health: A Retrospective Cohort Study.
Beer C, Rae F, Watt M, Trzaskowski M, Yates C, Semmler A, Voisey J. · 2026-08-26

open access unreviewed
10
Retinal Biomarkers of Folate and Vitamin B12 Metabolic Dysfunction: A Framework for Machine Learning-Assisted Detection of Cerebral Folate Deficiency.
Ayoub G, Brown C. · 2026-08-13

cited 1× open access unreviewed

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