Junction / hub Pathway metabolite unreviewed

Oxaloacetate

Pathways

Reactions involving Oxaloacetate

Every recorded step where this molecule takes part

All 13 Consumed 6 Produced 7

consumed Mitochondrial malate dehydrogenase Gluconeogenesis ST-0017

Oxaloacetate + NADH + H+ ↔ malate + NAD+
consumed Phosphoenolpyruvate carboxykinase (PEPCK) Gluconeogenesis ST-0019

Oxaloacetate + GTP → phosphoenolpyruvate + GDP + CO2
consumed Citrate synthase Fatty Acid Synthesis (De Novo Lipogenesis) ST-0060

Acetyl-CoA + oxaloacetate → citrate
consumed Cytosolic malate dehydrogenase Fatty Acid Synthesis (De Novo Lipogenesis) ST-0062

Oxaloacetate + NADH + H+ → malate + NAD+
consumed Citrate synthase Citric Acid Cycle (TCA / Krebs Cycle) ST-0269

Oxaloacetate + acetyl-CoA + H2O → citrate + CoA-SH
consumed Mitochondrial aspartate aminotransferase (GOT2) Malate-Aspartate Shuttle ST-0356

Oxaloacetate + glutamate <-> aspartate + alpha-ketoglutarate (matrix)

Showing all 6 reactions.

Pathway junctions through this molecule

Produced in one pathway, consumed in another

20 links

Produced in		Consumed in	Link
Amino Acid Catabolism Overview (glucogenic …	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Fatty Acid Synthesis (De Novo Lipogenesis)	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Gluconeogenesis	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Malate-Aspartate Shuttle	cross-category
Citric Acid Cycle (TCA / Krebs Cycle)	→	Fatty Acid Synthesis (De Novo Lipogenesis)	cross-category
Citric Acid Cycle (TCA / Krebs Cycle)	→	Gluconeogenesis	cross-category
Citric Acid Cycle (TCA / Krebs Cycle)	→	Malate-Aspartate Shuttle	within category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Gluconeogenesis	cross-category
Fatty Acid Synthesis (De Novo Lipogenesis)	→	Malate-Aspartate Shuttle	cross-category
Gluconeogenesis	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Gluconeogenesis	→	Fatty Acid Synthesis (De Novo Lipogenesis)	cross-category
Gluconeogenesis	→	Malate-Aspartate Shuttle	cross-category
Malate-Aspartate Shuttle	→	Citric Acid Cycle (TCA / Krebs Cycle)	within category
Malate-Aspartate Shuttle	→	Fatty Acid Synthesis (De Novo Lipogenesis)	cross-category
Malate-Aspartate Shuttle	→	Gluconeogenesis	cross-category
Transamination	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Transamination	→	Fatty Acid Synthesis (De Novo Lipogenesis)	cross-category
Transamination	→	Gluconeogenesis	cross-category
Transamination	→	Malate-Aspartate Shuttle	cross-category

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