Junction / hub Pathway metabolite unreviewed

Alpha-ketoglutarate

Pathways

Reactions involving Alpha-ketoglutarate

Every recorded step where this molecule takes part

All 14 Consumed 9 Produced 5

produced Alanine aminotransferase (ALT/GPT) Glucose-Alanine Cycle ST-0381

Pyruvate + glutamate -> alanine + alpha-ketoglutarate (muscle)
produced Multiple pathway-specific catabolic enzymes Amino Acid Catabolism Overview (glucogeni… ST-0147

Glucogenic carbon skeleton → pyruvate or a gluconeogenic TCA-cycle intermediate
produced Glutamate dehydrogenase Oxidative Deamination ST-0138

L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺
produced Malate-alpha-ketoglutarate antiporter (SLC25A11) Malate-Aspartate Shuttle ST-0354

Malate(cytosol) + alpha-ketoglutarate(matrix) <-> malate(matrix) + alpha-ketoglutarate(cytosol)
produced Mitochondrial aspartate aminotransferase (GOT2) Malate-Aspartate Shuttle ST-0356

Oxaloacetate + glutamate <-> aspartate + alpha-ketoglutarate (matrix)

Showing all 5 reactions.

Produced in one pathway, consumed in another

14 links

Produced in		Consumed in	Link
Amino Acid Catabolism Overview (glucogenic …	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Glucose-Alanine Cycle	cross-category
Amino Acid Catabolism Overview (glucogenic …	→	Transamination	within category
Glucose-Alanine Cycle	→	Amino Acid Catabolism Overview (glucogenic …	cross-category
Glucose-Alanine Cycle	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Glucose-Alanine Cycle	→	Transamination	cross-category
Malate-Aspartate Shuttle	→	Amino Acid Catabolism Overview (glucogenic …	cross-category
Malate-Aspartate Shuttle	→	Citric Acid Cycle (TCA / Krebs Cycle)	within category
Malate-Aspartate Shuttle	→	Glucose-Alanine Cycle	cross-category
Malate-Aspartate Shuttle	→	Transamination	cross-category
Oxidative Deamination	→	Amino Acid Catabolism Overview (glucogenic …	within category
Oxidative Deamination	→	Citric Acid Cycle (TCA / Krebs Cycle)	cross-category
Oxidative Deamination	→	Glucose-Alanine Cycle	cross-category
Oxidative Deamination	→	Transamination	within category

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