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Connectivity map

Each node is a pathway. An edge means a molecule produced by one is consumed by the other. Common carriers are excluded, otherwise everything joins to everything.

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Network

9 pathways · 10 edges
Gluconeogenesis → Cori Cycle (lactate shuttle): Glucose Glycogenolysis (Glycogen Breakdown) → Cori Cycle (lactate shuttle): Glucose Galactose Metabolism → Cori Cycle (lactate shuttle): Glucose Anaerobic Glycolysis / Lactic Acid Fermentation → Cori Cycle (lactate shuttle): Lactate Sphingolipid Degradation (Lysosomal) → Cori Cycle (lactate shuttle): Glucose Cori Cycle (lactate shuttle) → Pyruvate Oxidation / Link Reaction (Pyruvate Dehydrogenase Complex): Pyruvate Cori Cycle (lactate shuttle) → Gluconeogenesis: Pyruvate Cori Cycle (lactate shuttle) → Pyruvate Dehydrogenase Complex (Link Reaction, connecting glycolysis to the TCA cycle): Pyruvate Cori Cycle (lactate shuttle) → Anaerobic Glycolysis / Lactic Acid Fermentation: Pyruvate Cori Cycle (lactate shuttle) → Glucose-Alanine Cycle: Pyruvate Cori Cycle (lactate shuttle) Carbohydrate Metabolism 10 connections · Hub Cori Cycle (lactate shuttle) Galactose Metabolism Carbohydrate Metabolism 1 connection · Terminal Galactose Metabolism Gluconeogenesis Carbohydrate Metabolism 2 connections · Peripheral Gluconeogenesis Glucose-Alanine Cycle Carbohydrate Metabolism 1 connection · Terminal Glucose-Alanine Cycle Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism 1 connection · Terminal Glycogenolysis (Glycogen Brea… Pyruvate Oxidation / Link Reaction (Pyruvate Dehydrogenase Complex) Carbohydrate Metabolism 1 connection · Terminal Pyruvate Oxidation / Link Rea… Sphingolipid Degradation (Lysosomal) Lipid Metabolism 1 connection · Terminal Sphingolipid Degradation (Lys… Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration 2 connections · Peripheral Anaerobic Glycolysis / Lactic… Pyruvate Dehydrogenase Complex (Link Reaction, connecting glycolysis to the TCA cycle) Energy Metabolism & Cellular Respiration 1 connection · Terminal Pyruvate Dehydrogenase Comple…

Circles — how connected a pathway is

  • Hub Connects to a large share of the map. Disturb one of these and the effect travels widely.
  • Connector Several links in and out. Typical of a pathway that both consumes and supplies intermediates.
  • Peripheral A handful of links, usually to close relatives within the same category.
  • Terminal One or two links. Either a short pathway or one the source documents describe in isolation.

Lines — what the connections mean

  • Violet joins two different categories — for example carbohydrate metabolism feeding lipid metabolism. These are the interesting ones.
  • Grey joins two pathways inside the same category.
  • Thickness is the number of different molecules shared. A thick line means the two pathways trade several intermediates, not just one.
› How to read this map

Think of each circle as a factory and each line as a delivery route. A line is drawn from one pathway to another when the first one makes a molecule that the second one uses. So the map is not about which pathways look similar; it is about which ones hand material to each other.

Big violet circles are the busy junctions. They sit in the middle of many deliveries, which is usually why a defect in one of them shows up in several organ systems at once. Small grey circles at the edge either are short pathways or are described on their own in the source documents, so they have few recorded hand-offs.

Common carriers such as ATP, NAD+ and water are deliberately left out. They take part in almost every reaction, so including them would connect everything to everything and the picture would say nothing. What remains are the specific intermediates.

Two cautions. A line means a connection exists somewhere in this dataset, not that material actually flows that way in a given tissue at a given moment — check the compartment and tissue on each pathway page. And a missing line may only mean the source documents did not record that step, not that biology lacks it.

Hover any circle for its name and connection count, hover any line for the molecules it carries, and click either to open the pathway behind it.

Filter by category

Carbohydrate Metabolism Lipid Metabolism Amino Acid & Nitrogen Metabolism Nucleotide Metabolism Energy Metabolism & Cellular Respiration Cofactor & Vitamin Metabolism Xenobiotic & Drug Metabolism

Junction detail

Directed: produced in the first pathway, consumed in the second

10 links

Showing all 10 junctions.