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Connectivity map

Each node is a pathway. An edge means a molecule produced by one is consumed by the other. Common carriers are excluded, otherwise everything joins to everything.

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Only junctions through Glucose. Remove

Network

9 pathways · 20 edges
Gluconeogenesis → Glycolysis: Glucose Gluconeogenesis → Glycogenesis (Glycogen Synthesis): Glucose Gluconeogenesis → Anaerobic Glycolysis / Lactic Acid Fermentation: Glucose Gluconeogenesis → Sorbitol / Polyol Pathway: Glucose Gluconeogenesis → Cori Cycle (lactate shuttle): Glucose Glycogenolysis (Glycogen Breakdown) → Glycolysis: Glucose Glycogenolysis (Glycogen Breakdown) → Glycogenesis (Glycogen Synthesis): Glucose Glycogenolysis (Glycogen Breakdown) → Anaerobic Glycolysis / Lactic Acid Fermentation: Glucose Glycogenolysis (Glycogen Breakdown) → Sorbitol / Polyol Pathway: Glucose Glycogenolysis (Glycogen Breakdown) → Cori Cycle (lactate shuttle): Glucose Galactose Metabolism → Glycolysis: Glucose Galactose Metabolism → Glycogenesis (Glycogen Synthesis): Glucose Galactose Metabolism → Anaerobic Glycolysis / Lactic Acid Fermentation: Glucose Galactose Metabolism → Sorbitol / Polyol Pathway: Glucose Galactose Metabolism → Cori Cycle (lactate shuttle): Glucose Sphingolipid Degradation (Lysosomal) → Glycolysis: Glucose Sphingolipid Degradation (Lysosomal) → Glycogenesis (Glycogen Synthesis): Glucose Sphingolipid Degradation (Lysosomal) → Anaerobic Glycolysis / Lactic Acid Fermentation: Glucose Sphingolipid Degradation (Lysosomal) → Sorbitol / Polyol Pathway: Glucose Sphingolipid Degradation (Lysosomal) → Cori Cycle (lactate shuttle): Glucose Cori Cycle (lactate shuttle) Carbohydrate Metabolism 4 connections · Hub Cori Cycle (lactate shuttle) Galactose Metabolism Carbohydrate Metabolism 5 connections · Hub Galactose Metabolism Gluconeogenesis Carbohydrate Metabolism 5 connections · Hub Gluconeogenesis Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism 4 connections · Hub Glycogenesis (Glycogen Synthe… Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism 5 connections · Hub Glycogenolysis (Glycogen Brea… Glycolysis Carbohydrate Metabolism 4 connections · Hub Glycolysis Sorbitol / Polyol Pathway Carbohydrate Metabolism 4 connections · Hub Sorbitol / Polyol Pathway Sphingolipid Degradation (Lysosomal) Lipid Metabolism 5 connections · Hub Sphingolipid Degradation (Lys… Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration 4 connections · Hub Anaerobic Glycolysis / Lactic…

Circles — how connected a pathway is

  • Hub Connects to a large share of the map. Disturb one of these and the effect travels widely.
  • Connector Several links in and out. Typical of a pathway that both consumes and supplies intermediates.
  • Peripheral A handful of links, usually to close relatives within the same category.
  • Terminal One or two links. Either a short pathway or one the source documents describe in isolation.

Lines — what the connections mean

  • Violet joins two different categories — for example carbohydrate metabolism feeding lipid metabolism. These are the interesting ones.
  • Grey joins two pathways inside the same category.
  • Thickness is the number of different molecules shared. A thick line means the two pathways trade several intermediates, not just one.
› How to read this map

Think of each circle as a factory and each line as a delivery route. A line is drawn from one pathway to another when the first one makes a molecule that the second one uses. So the map is not about which pathways look similar; it is about which ones hand material to each other.

Big violet circles are the busy junctions. They sit in the middle of many deliveries, which is usually why a defect in one of them shows up in several organ systems at once. Small grey circles at the edge either are short pathways or are described on their own in the source documents, so they have few recorded hand-offs.

Common carriers such as ATP, NAD+ and water are deliberately left out. They take part in almost every reaction, so including them would connect everything to everything and the picture would say nothing. What remains are the specific intermediates.

Two cautions. A line means a connection exists somewhere in this dataset, not that material actually flows that way in a given tissue at a given moment — check the compartment and tissue on each pathway page. And a missing line may only mean the source documents did not record that step, not that biology lacks it.

Hover any circle for its name and connection count, hover any line for the molecules it carries, and click either to open the pathway behind it.

Filter by category

Carbohydrate Metabolism Lipid Metabolism Amino Acid & Nitrogen Metabolism Nucleotide Metabolism Energy Metabolism & Cellular Respiration Cofactor & Vitamin Metabolism Xenobiotic & Drug Metabolism

Junction detail

Directed: produced in the first pathway, consumed in the second

20 links

Showing all 20 junctions.