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Connectivity map

Each node is a pathway. An edge means a molecule produced by one is consumed by the other. Common carriers are excluded, otherwise everything joins to everything.

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Network

11 pathways · 14 edges
Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) → Triacylglycerol Synthesis and Lipolysis: Fatty acid, Glycerol, Triacylglycerol (TAG) Triacylglycerol Synthesis and Lipolysis → Beta-Oxidation of Fatty Acids: Fatty acid, Fatty acyl-CoA Triacylglycerol Synthesis and Lipolysis → Phospholipid Synthesis (Kennedy / CDP pathways): Diacylglycerol, Phosphatidic acid Phospholipid Degradation (Phospholipases) → Triacylglycerol Synthesis and Lipolysis: Diacylglycerol, Phosphatidic acid Glycerol-3-Phosphate Shuttle → Triacylglycerol Synthesis and Lipolysis: Dihydroxyacetone phosphate, Glycerol-3-phosphate Glycolysis → Triacylglycerol Synthesis and Lipolysis: Dihydroxyacetone phosphate Gluconeogenesis → Triacylglycerol Synthesis and Lipolysis: Dihydroxyacetone phosphate Fructose Metabolism (Fructolysis) → Triacylglycerol Synthesis and Lipolysis: Dihydroxyacetone phosphate Beta-Oxidation of Fatty Acids → Triacylglycerol Synthesis and Lipolysis: Fatty acyl-CoA Triacylglycerol Synthesis and Lipolysis → Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL): Triacylglycerol (TAG) Triacylglycerol Synthesis and Lipolysis → Sphingolipid Synthesis: Fatty acyl-CoA Triacylglycerol Synthesis and Lipolysis → Glycerol-3-Phosphate Shuttle: Glycerol-3-phosphate Anaerobic Glycolysis / Lactic Acid Fermentation → Triacylglycerol Synthesis and Lipolysis: Dihydroxyacetone phosphate Sphingolipid Synthesis → Triacylglycerol Synthesis and Lipolysis: Diacylglycerol Fructose Metabolism (Fructolysis) Carbohydrate Metabolism 1 connection · Terminal Fructose Metabolism (Fructoly… Gluconeogenesis Carbohydrate Metabolism 1 connection · Terminal Gluconeogenesis Glycolysis Carbohydrate Metabolism 1 connection · Terminal Glycolysis Beta-Oxidation of Fatty Acids Lipid Metabolism 2 connections · Peripheral Beta-Oxidation of Fatty Acids Lipoprotein Metabolism (Exogenous and Endogenous Pathways: chylomicrons, VLDL, LDL, HDL) Lipid Metabolism 2 connections · Peripheral Lipoprotein Metabolism (Exoge… Phospholipid Degradation (Phospholipases) Lipid Metabolism 1 connection · Terminal Phospholipid Degradation (Pho… Phospholipid Synthesis (Kennedy / CDP pathways) Lipid Metabolism 1 connection · Terminal Phospholipid Synthesis (Kenne… Sphingolipid Synthesis Lipid Metabolism 2 connections · Peripheral Sphingolipid Synthesis Triacylglycerol Synthesis and Lipolysis Lipid Metabolism 14 connections · Hub Triacylglycerol Synthesis and… Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration 1 connection · Terminal Anaerobic Glycolysis / Lactic… Glycerol-3-Phosphate Shuttle Energy Metabolism & Cellular Respiration 2 connections · Peripheral Glycerol-3-Phosphate Shuttle

Circles — how connected a pathway is

  • Hub Connects to a large share of the map. Disturb one of these and the effect travels widely.
  • Connector Several links in and out. Typical of a pathway that both consumes and supplies intermediates.
  • Peripheral A handful of links, usually to close relatives within the same category.
  • Terminal One or two links. Either a short pathway or one the source documents describe in isolation.

Lines — what the connections mean

  • Violet joins two different categories — for example carbohydrate metabolism feeding lipid metabolism. These are the interesting ones.
  • Grey joins two pathways inside the same category.
  • Thickness is the number of different molecules shared. A thick line means the two pathways trade several intermediates, not just one.
› How to read this map

Think of each circle as a factory and each line as a delivery route. A line is drawn from one pathway to another when the first one makes a molecule that the second one uses. So the map is not about which pathways look similar; it is about which ones hand material to each other.

Big violet circles are the busy junctions. They sit in the middle of many deliveries, which is usually why a defect in one of them shows up in several organ systems at once. Small grey circles at the edge either are short pathways or are described on their own in the source documents, so they have few recorded hand-offs.

Common carriers such as ATP, NAD+ and water are deliberately left out. They take part in almost every reaction, so including them would connect everything to everything and the picture would say nothing. What remains are the specific intermediates.

Two cautions. A line means a connection exists somewhere in this dataset, not that material actually flows that way in a given tissue at a given moment — check the compartment and tissue on each pathway page. And a missing line may only mean the source documents did not record that step, not that biology lacks it.

Hover any circle for its name and connection count, hover any line for the molecules it carries, and click either to open the pathway behind it.

Filter by category

Carbohydrate Metabolism Lipid Metabolism Amino Acid & Nitrogen Metabolism Nucleotide Metabolism Energy Metabolism & Cellular Respiration Cofactor & Vitamin Metabolism Xenobiotic & Drug Metabolism

Junction detail

Directed: produced in the first pathway, consumed in the second

14 links
Lipoprotein Metabolism (Exogenous and E… Triacylglycerol Synthesis and Lipolysis within

Fatty acid, Glycerol, Triacylglycerol (TAG)

Triacylglycerol Synthesis and Lipolysis Beta-Oxidation of Fatty Acids within

Fatty acid, Fatty acyl-CoA

Triacylglycerol Synthesis and Lipolysis Phospholipid Synthesis (Kennedy / CDP p… within

Diacylglycerol, Phosphatidic acid

Phospholipid Degradation (Phospholipase… Triacylglycerol Synthesis and Lipolysis within

Diacylglycerol, Phosphatidic acid

Glycerol-3-Phosphate Shuttle Triacylglycerol Synthesis and Lipolysis cross-category

Dihydroxyacetone phosphate, Glycerol-3-phosphate

Glycolysis Triacylglycerol Synthesis and Lipolysis cross-category

Dihydroxyacetone phosphate

Gluconeogenesis Triacylglycerol Synthesis and Lipolysis cross-category

Dihydroxyacetone phosphate

Fructose Metabolism (Fructolysis) Triacylglycerol Synthesis and Lipolysis cross-category

Dihydroxyacetone phosphate

Beta-Oxidation of Fatty Acids Triacylglycerol Synthesis and Lipolysis within

Fatty acyl-CoA

Triacylglycerol Synthesis and Lipolysis Lipoprotein Metabolism (Exogenous and E… within

Triacylglycerol (TAG)

Triacylglycerol Synthesis and Lipolysis Sphingolipid Synthesis within

Fatty acyl-CoA

Triacylglycerol Synthesis and Lipolysis Glycerol-3-Phosphate Shuttle cross-category

Glycerol-3-phosphate

Anaerobic Glycolysis / Lactic Acid Ferm… Triacylglycerol Synthesis and Lipolysis cross-category

Dihydroxyacetone phosphate

Sphingolipid Synthesis Triacylglycerol Synthesis and Lipolysis within

Diacylglycerol

Showing all 14 junctions.