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Connectivity map

Each node is a pathway. An edge means a molecule produced by one is consumed by the other. Common carriers are excluded, otherwise everything joins to everything.

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Network

12 pathways · 49 edges
Glycolysis → Gluconeogenesis: 1,3-Bisphosphoglycerate, 2-Phosphoglycerate, 3-Phosphoglycerate, Dihydroxyacetone phosphate, Fructose-1,6-bisphosphate, Fructose-6-phosphate, Glucose-6-phosphate, Glyceraldehyde-3-phosphate, Phosphoenolpyruvate, Pyruvate Gluconeogenesis → Glycolysis: 1,3-Bisphosphoglycerate, 2-Phosphoglycerate, 3-Phosphoglycerate, Dihydroxyacetone phosphate, Fructose-1,6-bisphosphate, Fructose-6-phosphate, Glucose, Glucose-6-phosphate, Glyceraldehyde-3-phosphate, Phosphoenolpyruvate Galactose Metabolism → Glycogenesis (Glycogen Synthesis): Glucose, Glucose-1-phosphate, Glucose-6-phosphate, UDP-glucose Glycogenolysis (Glycogen Breakdown) → Glycogenesis (Glycogen Synthesis): Glucose, Glucose-1-phosphate, Glucose-6-phosphate Fructose Metabolism (Fructolysis) → Glycolysis: Dihydroxyacetone phosphate, Fructose-6-phosphate, Glyceraldehyde-3-phosphate Fructose Metabolism (Fructolysis) → Gluconeogenesis: Dihydroxyacetone phosphate, Fructose-6-phosphate, Glyceraldehyde-3-phosphate Glycolysis → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glucose-6-phosphate, Glyceraldehyde-3-phosphate Gluconeogenesis → Glycogenesis (Glycogen Synthesis): Glucose, Glucose-6-phosphate Gluconeogenesis → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glucose-6-phosphate, Glyceraldehyde-3-phosphate Glycogenesis (Glycogen Synthesis) → Glycogenolysis (Glycogen Breakdown): Glucose-1-phosphate, Glucose-6-phosphate Glycogenesis (Glycogen Synthesis) → Galactose Metabolism: Glucose-1-phosphate, UDP-glucose Glycogenesis (Glycogen Synthesis) → Uronic Acid Pathway: Glucose-1-phosphate, UDP-glucose Glycogenolysis (Glycogen Breakdown) → Glycolysis: Glucose, Glucose-6-phosphate Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) → Glycolysis: Fructose-6-phosphate, Glyceraldehyde-3-phosphate Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) → Gluconeogenesis: Fructose-6-phosphate, Glyceraldehyde-3-phosphate Galactose Metabolism → Glycolysis: Glucose, Glucose-6-phosphate Galactose Metabolism → Glycogenolysis (Glycogen Breakdown): Glucose-1-phosphate, Glucose-6-phosphate Galactose Metabolism → Uronic Acid Pathway: Glucose-1-phosphate, UDP-glucose Glycolysis → Pyruvate Oxidation / Link Reaction (Pyruvate Dehydrogenase Complex): Pyruvate Glycolysis → Glycogenesis (Glycogen Synthesis): Glucose-6-phosphate Glycolysis → Glycogenolysis (Glycogen Breakdown): Glucose-6-phosphate Glycolysis → Fructose Metabolism (Fructolysis): Dihydroxyacetone phosphate Glycolysis → Glucose-Alanine Cycle: Pyruvate Gluconeogenesis → Glycogenolysis (Glycogen Breakdown): Glucose-6-phosphate Gluconeogenesis → Fructose Metabolism (Fructolysis): Dihydroxyacetone phosphate Gluconeogenesis → Sorbitol / Polyol Pathway: Glucose Gluconeogenesis → Cori Cycle (lactate shuttle): Glucose Glycogenesis (Glycogen Synthesis) → Glycolysis: Glucose-6-phosphate Glycogenesis (Glycogen Synthesis) → Gluconeogenesis: Glucose-6-phosphate Glycogenesis (Glycogen Synthesis) → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glucose-6-phosphate Glycogenolysis (Glycogen Breakdown) → Gluconeogenesis: Glucose-6-phosphate Glycogenolysis (Glycogen Breakdown) → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glucose-6-phosphate Glycogenolysis (Glycogen Breakdown) → Galactose Metabolism: Glucose-1-phosphate Glycogenolysis (Glycogen Breakdown) → Sorbitol / Polyol Pathway: Glucose Glycogenolysis (Glycogen Breakdown) → Uronic Acid Pathway: Glucose-1-phosphate Glycogenolysis (Glycogen Breakdown) → Cori Cycle (lactate shuttle): Glucose Fructose Metabolism (Fructolysis) → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glyceraldehyde-3-phosphate Galactose Metabolism → Gluconeogenesis: Glucose-6-phosphate Galactose Metabolism → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glucose-6-phosphate Galactose Metabolism → Sorbitol / Polyol Pathway: Glucose Galactose Metabolism → Cori Cycle (lactate shuttle): Glucose Sorbitol / Polyol Pathway → Fructose Metabolism (Fructolysis): Fructose Uronic Acid Pathway → Glycogenesis (Glycogen Synthesis): UDP-glucose Uronic Acid Pathway → Galactose Metabolism: UDP-glucose Cori Cycle (lactate shuttle) → Pyruvate Oxidation / Link Reaction (Pyruvate Dehydrogenase Complex): Pyruvate Cori Cycle (lactate shuttle) → Gluconeogenesis: Pyruvate Cori Cycle (lactate shuttle) → Glucose-Alanine Cycle: Pyruvate Glucose-Alanine Cycle → Pyruvate Oxidation / Link Reaction (Pyruvate Dehydrogenase Complex): Pyruvate Glucose-Alanine Cycle → Gluconeogenesis: Pyruvate Cori Cycle (lactate shuttle) Carbohydrate Metabolism 6 connections · Connector Cori Cycle (lactate shuttle) Fructose Metabolism (Fructolysis) Carbohydrate Metabolism 6 connections · Connector Fructose Metabolism (Fructoly… Galactose Metabolism Carbohydrate Metabolism 11 connections · Hub Galactose Metabolism Gluconeogenesis Carbohydrate Metabolism 15 connections · Hub Gluconeogenesis Glucose-Alanine Cycle Carbohydrate Metabolism 4 connections · Peripheral Glucose-Alanine Cycle Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism 11 connections · Hub Glycogenesis (Glycogen Synthe… Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism 12 connections · Hub Glycogenolysis (Glycogen Brea… Glycolysis Carbohydrate Metabolism 13 connections · Hub Glycolysis Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism 8 connections · Connector Pentose Phosphate Pathway (Ox… Pyruvate Oxidation / Link Reaction (Pyruvate Dehydrogenase Complex) Carbohydrate Metabolism 3 connections · Peripheral Pyruvate Oxidation / Link Rea… Sorbitol / Polyol Pathway Carbohydrate Metabolism 4 connections · Peripheral Sorbitol / Polyol Pathway Uronic Acid Pathway Carbohydrate Metabolism 5 connections · Connector Uronic Acid Pathway

Circles — how connected a pathway is

  • Hub Connects to a large share of the map. Disturb one of these and the effect travels widely.
  • Connector Several links in and out. Typical of a pathway that both consumes and supplies intermediates.
  • Peripheral A handful of links, usually to close relatives within the same category.
  • Terminal One or two links. Either a short pathway or one the source documents describe in isolation.

Lines — what the connections mean

  • Violet joins two different categories — for example carbohydrate metabolism feeding lipid metabolism. These are the interesting ones.
  • Grey joins two pathways inside the same category.
  • Thickness is the number of different molecules shared. A thick line means the two pathways trade several intermediates, not just one.
› How to read this map

Think of each circle as a factory and each line as a delivery route. A line is drawn from one pathway to another when the first one makes a molecule that the second one uses. So the map is not about which pathways look similar; it is about which ones hand material to each other.

Big violet circles are the busy junctions. They sit in the middle of many deliveries, which is usually why a defect in one of them shows up in several organ systems at once. Small grey circles at the edge either are short pathways or are described on their own in the source documents, so they have few recorded hand-offs.

Common carriers such as ATP, NAD+ and water are deliberately left out. They take part in almost every reaction, so including them would connect everything to everything and the picture would say nothing. What remains are the specific intermediates.

Two cautions. A line means a connection exists somewhere in this dataset, not that material actually flows that way in a given tissue at a given moment — check the compartment and tissue on each pathway page. And a missing line may only mean the source documents did not record that step, not that biology lacks it.

Hover any circle for its name and connection count, hover any line for the molecules it carries, and click either to open the pathway behind it.

Filter by category

Carbohydrate Metabolism Lipid Metabolism Amino Acid & Nitrogen Metabolism Nucleotide Metabolism Energy Metabolism & Cellular Respiration Cofactor & Vitamin Metabolism Xenobiotic & Drug Metabolism

Junction detail

Directed: produced in the first pathway, consumed in the second

49 links