Cystathionine beta-synthase (CBS)
Cofactors used
Clinical / pharmacological. Homocystinuria: marfanoid habitus, DOWNWARD lens dislocation, thrombosis; B6-responsive forms
What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
Homocysteine + L-serine → cystathionine + H₂O
Converts Homocysteine Serine into Cystathionine H2O
› Notes
Cystathionine β-synthase (CBS) uses PLP (vitamin B6) and a heme regulatory domain to catalyze the first transsulfuration step. It is the committed, essentially irreversible, rate-controlling step of transsulfuration and is activated by SAM when methionine/SAM abundance is high.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Harnessing gasotransmitters for orthopaedic infection therapy: Mechanisms and advanced delivery platforms.
Zhang JY, Yang YQ, Zhang ZX, Jin JL, Luo ZY, Wang DY, Ruan CX, Dai TZ, Huang YL, Xu J, Shi JW, Li JY, Lei PF. · 2026-09-03
open access unreviewed -
2
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
3
A universal consuming endogenous H<sub>2</sub>S strategy using bismuth-metal-organic nanocapsule networks for overcoming osteosarcoma cisplatin resistance.
Lin Y, Yuan K, Liu Y, Du Y, Chang H, Hou L, Liang Y, Huang K, Yang S, Tang T. · 2026-08-18
open access unreviewed -
4
Ferroptosis in major depressive disorder: Molecular mechanisms, cellular vulnerability, and therapeutic opportunities.
Kong D, Duan R, Wang X, Wang X, Zhao J. · 2026-09-18
open access unreviewed -
5
A tool supporting person-centred communication among people with cognitive complaints, care partners, and clinicians: a feasibility study.
de Rijke TJ, Engelsma T, Hendriksen HMA, Vasseur D, Koek HL, van den Berg JW, Schoonenboom N, Smets EMA, Viss… · 2026-09-10
open access unreviewed -
6
Integrated risk prioritization of rubber additives based on hazard ranking and exposure characterization.
Wang S, Dai W, Wang B, Heng L. · 2026-09-02
open access unreviewed -
7
Homocystinuria symptomatology collected through an international patient-report data program as a source for natural history data.
Parke B, Bartke D, Beek G, Talebizadeh Z, Chapman KA, Baker J, Thomas JA. · 2026-09-11
open access unreviewed -
8
Identification of rare maternal copy number variants by genome-wide analysis of noninvasive prenatal screening data in 113,017 pregnant women.
Hu L, Cao X, Zeng S, Wen L, Zhong J, Liu Y, Liu W, Wei F. · 2026-09-09
open access unreviewed -
9
What do we know about redox status? A review in neonates of mothers with preeclampsia.
Avilés-Garcia JC, Aguilar-Dueñas MF, Ceballos G, Torres-Ramos YD. · 2026-08-26
open access unreviewed -
10
Homocysteine, cysteine and methionine are associated with 90-day prognosis in intracerebral hemorrhage patients.
Fang M, Xia T, Yin Y. · 2026-08-21
open access unreviewed
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