Cystathionine beta-synthase (CBS)
Cofactors used
Clinical / pharmacological. Homocystinuria: marfanoid habitus, DOWNWARD lens dislocation, thrombosis; B6-responsive forms
What it does, reaction by reaction
Methionine Cycle / Transmethylation (SAM Cycle, homocysteine) Amino Acid & Nitrogen Metabolism · Cytosol
Homocysteine + L-serine → cystathionine + H₂O
Converts Homocysteine Serine into Cystathionine H2O
› Notes
Cystathionine β-synthase (CBS) uses PLP (vitamin B6) and a heme regulatory domain to catalyze the first transsulfuration step. It is the committed, essentially irreversible, rate-controlling step of transsulfuration and is activated by SAM when methionine/SAM abundance is high.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Impact of COVID-19 pandemic on surgical cancer care disparities according to socioeconomic status.
van Vuren RMG, van den Hoek R, Kruijff S, Heineman DJ, Kok NFM, Swijnenburg RJ, Visser MR, Gisbertz SS, Hendr… · 2026-06-03
open access unreviewed -
2
Design, synthesis, and biological evaluation of 6-aryl-3-(3,4,5-trimethoxyphenyl)imidazo[1,2-a]pyridine derivatives as novel tubulin inhibitors with potent anticancer efficacy.
Xu W, Zhang Y, Xu Q, Zhao H, Cui L, Wang C. · 2026-06-17
open access unreviewed -
3
Significance of GSH and H<sub>2</sub>S regulation for cancer: an intricate interplay between diet, microbiota, metabolic reprogramming, and immune health.
Majumder A, Majumder S, Bano S, Sen K, Nayak KB. · 2026-06-11
open access unreviewed -
4
Benefit finding and caregiving burden among primary caregivers of patients with advanced cancer in China: A latent profile analysis.
Jin X, Wang Y, Wu S, Zhang Z, Zhao S, Liu L, Lu X, Zheng L, Wang Z, Lv Y, Lei Y, Du H. · 2026-05-07
open access unreviewed -
5
Albumin as a dynamic extracellular redox regulator: from Cys34 oxidation biomarkers to polysulfide-mediated homeostatic mechanisms and clinical applications.
Ishima Y, Watanabe H, Ikeda-Imafuku M, Maeda H, Maruyama T, Otagiri M, Chuang VTG. · 2026-06-02
open access unreviewed -
6
Sulfide dynamics at the gut-microbiota interface: diet, oxygen and redox interplay.
Kumar R, Banerjee R. · 2026-06-02
open access unreviewed -
7
A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis.
Deng Q, Li C, Luo J, Yin M, Qian S, Li L. · 2026-05-14
open access unreviewed -
8
Between reality and meaning: a qualitative study on virtual reality as a compassionate technology in end-of-life care.
Chatchumni M, Phibunnithikasem P, Thatsiriniratkul R, Prasertsri T, Chotikunnan R, Chotikunnan P. · 2026-05-06
open access unreviewed -
9
Differential properties of NS1 glycoproteins in West Nile and Usutu viruses.
Revel J, Leroy J, Delbecq S, Constant O, Henry Marty F, Naili C, Barthès A, Nagy A, Schmidt-Chanasit J, Cadar… · 2026-05-29
open access unreviewed -
10
Airway organoids reveal patterns of influenza A tropism and adaptation in wildlife species.
Tarrés-Freixas F, Ceada G, Català-Moll F, Casadellà M, Tolosa-Alarcón S, Franco-Trepat E, Boreika R, Almagro-… · 2026-04-17
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.