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unreviewed

Alpha-ketoglutarate dehydrogenase complex

1 reactions · 1 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid) FAD · B2 (Riboflavin) Lipoamide Mg2+ · Magnesium NAD+ · B3 (Niacin) NADH · B3 (Niacin) TPP (B1) · B1 (Thiamine)

Clinical / pharmacological. Requires the same five cofactors as PDC; thiamine-sensitive

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 4 Irreversible

Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+

Converts Alpha-ketoglutarate CoA-SH NAD+ into Succinyl-CoA CO2 NADH H+

› Notes

Required cofactors: TPP, lipoic acid/lipoamide, CoA-SH, FAD, NAD+, and Mg2+, with E1, E2, and E3 activities analogous to PDC. This is an essentially irreversible and important regulatory step; it is inhibited by NADH and succinyl-CoA.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Citric Acid Cycle (TCA / Krebs Cycle)

Accelerated by

Ca2+ in skeletal and cardiac muscle; ADP

Inhibited by

NADH, succinyl-CoA, high ATP

Hormonal control

Ca2+-linked adrenergic/muscle contraction signals promote activity; endocrine control is mostly indirect

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Exogenous indole promotes florfenicol tolerance in <i>Edwardsiella tarda</i>.

    Zheng Y, Fu L, Cao Z, Zhang T, Fei J, Jiang M, Zhou Y, Shi Z, Su Y. · 2026-01-24

    cited 1× open access unreviewed
  2. 2
    Nitric oxide-driven Warburg reprogramming at the NOS2-COX2 axis: An integrative engine of cancer hallmarks.

    Coutinho LL, Palmieri EM, Ridnour LA, Cheng RYS, Heinz WF, Anderson SK, Billiar TR, Chang J, Lockett SJ, Rang… · 2026-06-02

    open access unreviewed
  3. 3
    Process-level design of engineered microalgal-bacterial systems for carbon-efficient nitrogen removal from low C/N wastewater: carbon/electron redistribution revealed by metabolic network analysis.

    Nie X, Qin J, Liu M, Wang H, Hou K, Duan Y. · 2026-06-01

    unreviewed
  4. 4
    Aberrant protein S-nitrosylation disrupts axonal development and metabolic homeostasis in a Cntnap2 mouse model of autism.

    Kartawy M, Ojha SK, Nimgampalle M, Amal H. · 2026-05-28

    open access unreviewed
  5. 5
    Metabolic Programming of β-Cell Fate, State, and Function through Time and Space.

    MacDonald TL, Bonner-Weir S. · 2026-01-16

    cited 1× unreviewed
  6. 6
    The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation.

    Chen XY, Xu KJ, Zhou JX, Wu LZ, Feng DY, Guan YF, Li HH, Yang GX, Qian Y, Mi MH, Wu SF, Zhang ZY, Chen QT, Zh… · 2026-08-07

    unreviewed
  7. 7
    TFF1-mediated suppression of the TCA cycle promotes bone metastasis in triple-negative breast cancer.

    Chen H, Xu Y, Liu Y, Tang Y, Qiu J, Lei L, Lin P, Chen Y, Wu X. · 2026-06-09

    open access unreviewed
  8. 8
    Sodium dehydroacetate alleviates surface discoloration in fresh-cut lettuce by regulating energy metabolism.

    Feng T, Cheng H, Li Y, Du H, Zuo X, Shen Y, Wang J, Zhang W, Cai Z, Zhu L. · 2026-05-01

    unreviewed
  9. 9
    Loss of LipT2 disrupts mitochondrial protein lipoylation and metabolic homeostasis in Drosophila melanogaster.

    Kishita Y, Tsuda M, Sato-Miyata Y, Takeo S, Aigaki T. · 2026-07-29

    unreviewed
  10. 10
    SLC25A1 drives lipid metabolic reprogramming promoting liver injury leading to hepatocellular carcinoma.

    Shahid M, Ashfaq I, Haider B, Tayyeb A. · 2026-07-17

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.