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unreviewed

Alpha-ketoglutarate dehydrogenase complex

1 reactions · 1 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid) FAD · B2 (Riboflavin) Lipoamide Mg2+ · Magnesium NAD+ · B3 (Niacin) NADH · B3 (Niacin) TPP (B1) · B1 (Thiamine)

Clinical / pharmacological. Requires the same five cofactors as PDC; thiamine-sensitive

What it does, reaction by reaction

1 reactions

Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix

step 4 Irreversible

Alpha-ketoglutarate + CoA-SH + NAD+ → succinyl-CoA + CO2 + NADH + H+

Converts Alpha-ketoglutarate CoA-SH NAD+ into Succinyl-CoA CO2 NADH H+

› Notes

Required cofactors: TPP, lipoic acid/lipoamide, CoA-SH, FAD, NAD+, and Mg2+, with E1, E2, and E3 activities analogous to PDC. This is an essentially irreversible and important regulatory step; it is inhibited by NADH and succinyl-CoA.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Citric Acid Cycle (TCA / Krebs Cycle)

Accelerated by

Ca2+ in skeletal and cardiac muscle; ADP

Inhibited by

NADH, succinyl-CoA, high ATP

Hormonal control

Ca2+-linked adrenergic/muscle contraction signals promote activity; endocrine control is mostly indirect

Recent literature

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Europe PMC · fetched just now · sorted by publication date

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    Natural products alleviate exercise-induced fatigue by modulating gut microbiota: a systematic review.

    Yan D, Jiao T. · 2026-09-07

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    Frye RE, Rossignol DA. · 2026-08-06

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    Lin W, Chen Z, Liu W, Wang X, Song W, He A, Mao Y, Guo H, Jiang Z, Zhou C, Yu Y, Liu W. · 2026-07-01

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    A senescent metabolism-modulating hierarchical scaffold restores NAD<sup>+</sup> homeostasis and redox balance for aged bone repair.

    Jiang J, Chen J, Wang X, Zhang X, Lv H, Wu C, Han L, Zhu Y. · 2026-06-27

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    Exogenous indole promotes florfenicol tolerance in <i>Edwardsiella tarda</i>.

    Zheng Y, Fu L, Cao Z, Zhang T, Fei J, Jiang M, Zhou Y, Shi Z, Su Y. · 2026-01-24

    cited 3× open access unreviewed
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    Proteomic Signatures of Noise-Induced Hearing Loss in the Mouse Cochlea.

    Batissoco AC, Alencar-Coutinho D, Ferreira-Scatone AC, Diogo-Cavassana S, Oiticica J, Lezirovitz K, Bento RF. · 2026-10-01

    open access unreviewed
  7. 7
    Pdcd4-Rictor interaction suppresses mTORC2-PFKFB3 axis and tumorigenesis in NSCLC.

    Wang Q, Xin Y, Zokaei E, Zeng L, Piecoro D, Chen M, Zhang Y, Yang KS, Wang C, Liu X, Yang HS. · 2026-08-26

    open access unreviewed
  8. 8
    Murine metabolic HFpEF is associated with altered mitochondrial substrate handling and S-nitrosylation remodeling.

    Li H, Cui H, Wang D, Leuschner F, Heineke J, Hu J, Bibli SI. · 2026-08-12

    open access unreviewed
  9. 9
    DLST drives lung adenocarcinoma progression by modulating cuproptosis-related copper homeostasis and apoptosis via an EP300-dependent mechanism.

    Huang T, Chen L, Li Z, Ling X, Ren K. · 2026-08-14

    open access unreviewed
  10. 10
    Effects of in ovo dextrose, niacin, and retinoic acid administration on embryonic metabolism, antioxidant defense, and hepatic gene expression in long-stored broiler breeder eggs.

    Vicil S, Özbaşer Bulut FT. · 2026-07-02

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.