Succinyl-CoA synthetase (succinate thiokinase)
Cofactors used
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Succinyl-CoA + GDP + Pi ⇌ succinate + GTP + CoA-SH
Converts Succinyl-CoA GDP Pi into Succinate GTP CoA-SH
› Notes
Required substrates/cofactors: GDP (or ADP in some tissue-specific isoenzymes), inorganic phosphate, and Mg2+. This reversible step produces the cycle’s direct high-energy phosphate: 1 GTP, readily converted to ATP by nucleoside diphosphate kinase.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Multifaceted Actions of Succinate as a Signaling Transmitter Vary with Its Cellular Locations.
Guo Y, Cho SW, Saxena D, Li X. · 2020-03-01
cited 35× open access unreviewed -
2
Two transgenic mouse models for β-subunit components of succinate-CoA ligase yielding pleiotropic metabolic alterations.
Kacso G, Ravasz D, Doczi J, Németh B, Madgar O, Saada A, Ilin P, Miller C, Ostergaard E, Iordanov I, Adams D,… · 2016-08-05
cited 25× open access unreviewed -
3
Expanding the phenotypic spectrum of Succinyl-CoA ligase deficiency through functional validation of a new SUCLG1 variant.
Donti TR, Masand R, Scott DA, Craigen WJ, Graham BH. · 2016-07-25
cited 14× unreviewed -
4
Phosphohistidine phosphatase 1 (PHPT1) also dephosphorylates phospholysine of chemically phosphorylated histone H1 and polylysine.
Ek P, Ek B, Zetterqvist Ö. · 2015-01-09
cited 17× open access unreviewed -
5
Biochemistry and evolution of anaerobic energy metabolism in eukaryotes.
Müller M, Mentel M, van Hellemond JJ, Henze K, Woehle C, Gould SB, Yu RY, van der Giezen M, Tielens AG, Marti… · 2012-06-01
cited 563× unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.