Mitochondrial pyruvate carboxylase
Cofactors used
Clinical / pharmacological. PC deficiency: lactic acidosis, hypoglycaemia, neurological disease
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Pyruvate + HCO3− + ATP → oxaloacetate + ADP + Pi
Converts Pyruvate HCO3- ATP into Oxaloacetate ADP Pi
› Notes
Mitochondrial pyruvate carboxylase requires covalently bound biotin, ATP, Mg2+, and bicarbonate as the CO2 source. This is the first bypass of pyruvate kinase and is effectively irreversible; it is allosterically activated by acetyl-CoA, linking fatty-acid oxidation to glucose production.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
2026 iCARDIO Alliance Global Implementation Guidelines on Heart Failure.
Chopra V, Abraham WT, Amir O, Anker SD, Atherton JJ, Bacal F, von Bardeleben RS, Brito D, Burgos LM, Butler J… · 2027-10-13
unreviewed -
2
Global, regional, and national burden of exposure to chewing tobacco, 1990-2023: a systematic analysis of the Global Burden of Disease Study 2023.
GBD 2023 Chewing Tobacco Collaborators. · 2027-07-20
unreviewed -
3
Chewing tobacco: the neglected component of the tobacco epidemic.
Banik PC, Zaman MM. · 2027-07-20
unreviewed -
4
Recent Development of Endo-hepatology.
Yamamiya A, Irisawa A, Inaba Y, Romero-Castro R. · 2026-08-13
open access unreviewed -
5
Non-visualized Ultrasonography Should Remain Indeterminate in Patency Capsule Localization.
Koulaouzidis A, Toth E. · 2026-06-27
open access unreviewed -
6
In situ bioactive nanocoating enables transocular delivery of permeable drug for dual-location intervention of ocular surface and fundus disorders.
Wang Z, Lv W, Su Y, Yao T, Lu Y, Wang C, Wang C, Yu Y, Chen J, Qi Q, Pang Y, Wang Z, Wu F. · 2026-09-22
open access unreviewed -
7
A designable twist-densification route to bioactive collagen hydrogel yarns approaching tendon-like mechanics.
Xie Y, Wu W, Zhang W, Peng X, Sun T, Liu Y, Zhang Z, Elson EL, Genin GM, Huang G. · 2026-09-17
open access unreviewed -
8
Click chemistry-modified cardiomyocytes enhance cardiac contractility and prevent remodeling in ischemia-reperfusion injured hearts.
Lee D, Sim WS, Park JH, Han DY, Kim SJ, An JR, Seo MS, Kim JJ, Cheon SY, Hong H, Choi SW, Ban K, Koo H, Park … · 2026-09-16
open access unreviewed -
9
Engineering bioactive citrate-based hydrogels for wound repair: From structure-function design to microenvironmental regulation.
Zhang L, Lei B, Zhao H. · 2026-09-08
open access unreviewed -
10
An oral coral-like resveratrol nanocomplex protects against dry eye disease through ocular and systemic redox homeostasis.
Cui Q, Li Y, Xie M, Liu Z, Guo Y, Zang Y, Bao J, Wu Q, Tian L, Jie Y. · 2026-09-04
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.