Mitochondrial pyruvate carboxylase
Cofactors used
Clinical / pharmacological. PC deficiency: lactic acidosis, hypoglycaemia, neurological disease
What it does, reaction by reaction
Gluconeogenesis Carbohydrate Metabolism · Cytosol + mitochondrion + ER
Pyruvate + HCO3− + ATP → oxaloacetate + ADP + Pi
Converts Pyruvate HCO3- ATP into Oxaloacetate ADP Pi
› Notes
Mitochondrial pyruvate carboxylase requires covalently bound biotin, ATP, Mg2+, and bicarbonate as the CO2 source. This is the first bypass of pyruvate kinase and is effectively irreversible; it is allosterically activated by acetyl-CoA, linking fatty-acid oxidation to glucose production.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Deep Learning-driven synergistic engineering of PET hydrolase for post-consumer PET depolymerization.
Shao C, Shen X, Long J, Cui Z, Chen B, Tan T. · 2026-07-02
unreviewed -
2
Prostate Cancer Care for Men with an Intellectual Disability: A Population-based Cohort Study of Symptoms, Diagnosis, Treatment, and Survival.
Kennedy OJ, Chauhan U, Gorman L, Lorigan P, Merriel SWD, Staa TV, Wright A, Ashcroft DM. · 2027-01-31
unreviewed -
3
The mediating role of platelet indices on pre-pregnancy body mass index and late-onset preeclampsia.
Tang Y, Song M, Wu Q, Xing X, Miao Y, You X. · 2026-08-10
unreviewed -
4
Guanidinoacetic acid enhances Tibetan sheep-meat quality through the gut-muscle axis: insights from metabolome-microbiome integration.
Sa R, Zhang F, Zhang X, Zhang Y, Hou S, Gui L. · 2026-07-27
unreviewed -
5
Effects of extending interval between presynchronization and breeding protocols and prostaglandin F2α administration before breeding protocol on reproductive performance of Holstein dairy cows during summer.
Baghbanani RH, Mobedi E, Mohieddini AA, Pooladzadeh P, Zarabadipour S, Vojgani M, Gharagozlou F, Akbarinejad … · 2026-07-24
unreviewed -
6
Development of a nomogram for predicting hyperkalemia in advanced chronic kidney disease.
Chávez-Iñiguez JS, Ornelas-Ruvalcaba RL, Rodríguez-García G, Navarro-Blackaller G, Medina-González R, Gallard… · 2026-08-04
unreviewed -
7
Present status of prostate cancer diagnosis, limitations, challenges, and future endeavors.
Hooda K, Chatterjee M, Sharma AP, Aggarwal N, Sharma J. · 2026-08-03
unreviewed -
8
Operationalizing the One Health approach at the intersection of research and development: a study protocol for the ELUZO project in Senegal and Burkina Faso.
Hubert M, Martin M, Carabin H, Parmley J, Gilbert-Vanasse M, Kafando A, Seck R, Murphy HM, Ba MF, Ilboudo AK,… · 2026-07-31
unreviewed -
9
Artificial intelligence for pulmonary embolism detection: Is it comparable to radiology residents?
Chrysostomou PC, Platon A, Jaksic C, Meyer R, Desmettre T, Poletti PA. · 2026-07-13
unreviewed -
10
Exploration of extracellular vesicles from porcine endometrial cells for enhancing the development of parthenogenetic embryos.
Peng SY, Feng Y, Lin MJ, Chang SC, Huang JW, Shen PC, Yang KT, Huang CW, Chou CJ, Shaw SW. · 2026-06-22
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.