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unreviewed

Methylene-THF dehydrogenase (MTHFD1)

1 reactions · 1 pathways

Cofactors used

NADP+ · B3 (Niacin) NADPH · B3 (Niacin) THF (folate) · B9 (Folate)

What it does, reaction by reaction

1 reactions

One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 3 Reversible

5,10-Methylene-THF + NADP⁺ ⇌ 5,10-methenyl-THF + NADPH + H⁺

Converts 5,10-Methylene-THF NADP+ into 5,10-Methenyl-THF NADPH H+

› Notes

The dehydrogenase activity of cytosolic trifunctional MTHFD1 (or mitochondrial MTHFD2/MTHFD2L) interconverts these folate species. Cofactor preference is enzyme- and compartment-specific; MTHFD1 uses NADP⁺, whereas mitochondrial MTHFD2 commonly uses NAD⁺.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    A genome-wide CRISPR knockout screen identified host genes essential for Brucella invasion and intracellular survival.

    Wang X, Wu S, Ding Y, Ding J, Li P, Lian Z. · 2026-08-19

    open access unreviewed
  2. 2
    Influence of <i>MTHFD1L</i> variants on the susceptibility to hypertension in the Chinese Han population.

    Li Q, Wang L, Li X, Xie P, Zhang Y, Zhou X, Ding Y, Tong S. · 2026-04-07

    open access unreviewed
  3. 3
    Essential Oral Single Nutritional Therapy Products for Inherited Metabolic Diseases: Evidence and Consensus Assessment Using a Modified Delphi Method.

    Stolwijk NN, Penninx BMF, Bosch AM, Langeveld M, Salomons GS, Hollak CEM, Essential Nutritional Therapy Produ… · 2026-11-01

    open access unreviewed
  4. 4
    CD112 Lactylation Drives Dual Immune Evasion From CD8+ T Cells and NK Cells.

    Xu Z, Zhang X, Dong F, Shen N, Zhou J, Xi Z, Wu Z. · 2026-10-04

    open access unreviewed
  5. 5
    Post‑translational modification‑governed immune states in cancer immunity: Biomarker implications for checkpoint competence, tumor visibility and immunotherapy resistance (Review).

    Pan J, Li B, Lin R, Fang C, Lau LY, Hong Z, Chen Y. · 2026-08-21

    open access unreviewed
  6. 6
    Somatic Mutation Profile in Normal Tissue Adjacent to Tumor in Colorectal Carcinoma Patients: Functional Effect on Gene Expression and Potential Implications for Precision Medicine.

    Jasmine F, Vasiljevs D, Almazan A, Ahsan H, Kibriya MG. · 2026-09-18

    open access unreviewed
  7. 7
    Exploratory Association of 5' and 3' UTRs Variants in <i>TYMS</i> and <i>CCND1</i> with Severe Hematologic Toxicity in Pediatric Acute Lymphoblastic Leukemia.

    Rojo-Serrato D, Flores-Murrieta FJ, Rosas-Vargas H, Jiménez-Hernández E, Núñez-Enríquez JC, González-Torres C… · 2026-09-12

    open access unreviewed
  8. 8
    Folate: An Emerging Target in Type 2 Diabetes Mellitus and Its Complications.

    Xiao X, Qin S, Jiang Z, Huo Y, Li J, Yang M. · 2026-09-17

    open access unreviewed
  9. 9
    Germany's Epidemiological Data on Cleft Lip and Palate After the Chernobyl Nuclear Power Plant Accident: A Systematic Literature Review.

    Molsen CW, Grün P, Schnell CP, Turhani F, Fitzek S, Meier M, Turhani D. · 2026-09-01

    open access unreviewed
  10. 10
    High-Content CRISPR Screening: Methods and Applications.

    Zhang Y, Zhang Y, Tang X, Deng X, Zhou Y, Wu Y, Luo J. · 2026-09-08

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.