Methylene-THF dehydrogenase (MTHFD1)
Cofactors used
What it does, reaction by reaction
One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion
5,10-Methylene-THF + NADP⁺ ⇌ 5,10-methenyl-THF + NADPH + H⁺
Converts 5,10-Methylene-THF NADP+ into 5,10-Methenyl-THF NADPH H+
› Notes
The dehydrogenase activity of cytosolic trifunctional MTHFD1 (or mitochondrial MTHFD2/MTHFD2L) interconverts these folate species. Cofactor preference is enzyme- and compartment-specific; MTHFD1 uses NADP⁺, whereas mitochondrial MTHFD2 commonly uses NAD⁺.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
-
1
Influence of <i>MTHFD1L</i> variants on the susceptibility to hypertension in the Chinese Han population.
Li Q, Wang L, Li X, Xie P, Zhang Y, Zhou X, Ding Y, Tong S. · 2026-04-07
open access unreviewed -
2
MTHFD1 Deficiency in Two Unrelated Children: Highlights on Phenotypic Spectrum and Response to Folic Acid Therapy.
Altammar F, Elsayed H, Elshinawy M, Al-Herz W. · 2026-06-16
unreviewed -
3
Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study.
Eigbefoh-Addeh A, Salas-Huetos A, Ramos-Rodríguez C, Santos-Calderón LA, Agarwal R, Salas-Salvadó J, Babio N,… · 2026-06-06
unreviewed -
4
Exploring potential biomarkers of diffuse large B-cell lymphoma through multi-dimensional data.
Li C, Han X, Hu X, Du S, An P, Wang D. · 2026-02-25
unreviewed -
5
LncPTEC mediated homocysteine accumulation elevates oxidative stress via UBQLN1-dependent MTHFD1 ubiquitination in DKD.
Wang Q, Wu T, Li P, Zha H, Wu K, Liu H, Peng R, Peng X, Lin Z, Lv D, Liao X, Sun Y, Zhang Z. · 2026-07-07
unreviewed -
6
Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus.
Jeandel M, Alberto JM, Baspinar O, Robert A, Dreumont N, Alsahly Z, Meyre D, Guéant JL, Coelho D. · 2026-07-01
open access unreviewed -
7
A mathematical model of folate-mediated one-carbon metabolism in Down syndrome.
Piovesan A, Poluzzi D, Ramacieri G, Locatelli C, Antonaros F, Vione B, Caracausi M, Pelleri MC, Marchetti L. · 2026-06-26
unreviewed -
8
Integrating Genome-Scale Metabolic Modeling with Machine Learning Improves Gene Essentiality Prediction in Triple-Negative Breast Cancer.
Kim BK, Gu C, Farh ME, Ryu JY. · 2026-06-03
open access unreviewed -
9
Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis.
Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanj… · 2026-06-10
open access unreviewed -
10
Patterns of miRNA Expression in Primary and Metastatic Wilms Tumor.
Csók Á, Micsik T, Magyar Z, Tornóczky T, Kuthi L, Kabai AB, Szirák K, Szilágyi M, Csóka M, Ottóffy G, Soltész… · 2026-06-10
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.