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unreviewed

Glutamate dehydrogenase

1 reactions · 1 pathways

Cofactors used

H2O NAD+ · B3 (Niacin) NADH · B3 (Niacin) NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

Clinical / pharmacological. Activating mutations: hyperinsulinism-hyperammonaemia syndrome

What it does, reaction by reaction

1 reactions

Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix

step 1 Reversible

L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺

Converts Glutamate NAD+ (or NADP+) H2O into Alpha-ketoglutarate NH4+ NADH (or NADPH) H+

› Notes

Glutamate dehydrogenase catalyzes oxidative deamination in the mitochondrial matrix. NAD⁺ is generally the major oxidant during net hepatic glutamate oxidation, although the enzyme can use NADP⁺; the reaction is reversible and is the principal regulated route for release of free ammonia from glutamate.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Oxidative Deamination

Accelerated by

ADP, GDP; leucine allosterically activates the mammalian enzyme

Inhibited by

ATP, GTP; high-energy charge

Hormonal control

Glucagon and cortisol increase hepatic amino-acid catabolic/ureagenic capacity indirectly; insulin suppresses net amino-acid catabolism in the fed state

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Impact of chronic dietary aflatoxin B1 intake on rumen fermentation, hepatic health, oxidative stress, inflammation, and glucose-lipid metabolism in fat-tailed ewes.

    Ider N, Khalilvandi-Behroozyar H, Ahmadpour A, Farhangpajouh F, Sahebi-Ala M, Chen Y, Hosseini Ghaffari M. · 2026-07-08

    unreviewed
  2. 2
    Efficacy of tannins as silage additives to inhibit deamination process during ensiling: a meta-analysis and <i>in silico</i> approach.

    Susanto I, Mahendra FR, Azzahra FR, Rahmadani M, Ridwan R, Wiryawan KG, Laconi EB, Jayanegara A. · 2026-06-15

    unreviewed
  3. 3
    Photosynthetic production of glutamine through metabolic analysis-based engineering of <i>Picosynechococcus</i> sp. PCC 7002.

    Kato Y, Tsuji A, Haraguchi Y, Shimizu T, Kondo A, Hasunuma T. · 2026-06-17

    unreviewed
  4. 4
    Detection of zoonotic protozoa in raccoons (<i>Procyon lotor</i>) from aquaculture zones in Saxony (Germany): One health perspective.

    Lindhorst ZTL, Unterköfler MS, Solarczyk P, Striese M, Jeschke D, Striese E, Ansorge H, Fuehrer HP, Heddergot… · 2026-06-13

    open access unreviewed
  5. 5
    Systematic metabolic engineering of <i>Escherichia coli</i> for high-level production of pseudouridine via pathway optimization and precursor enhancement.

    Song J, Shen W, Xia Y, Zhou L, Zhou Y, Yang H, Chen X. · 2026-04-06

    open access unreviewed
  6. 6
    Therapeutic strategies of metabolic reprogramming in non-small cell lung carcinoma.

    Liu J, Qian F. · 2026-04-15

    unreviewed
  7. 7
    Advanced breeding techniques in <i>Brassica juncea</i> L. for sustainable production under changing climate.

    Pawaiya A, Pradhan RK, Johri AK, Dua M. · 2026-04-04

    open access unreviewed
  8. 8
    Protective effects of adenosine triphosphate, thiamin, thiamin pyrophosphate, and their combination against linezolid-induced renal injury and lactic acidosis in rats.

    Admis O, Yavuzer B, Mammadov R, Suleyman B, Altuner D, Mendil AS, Yucel N, Suleyman H. · 2026-01-25

    open access unreviewed
  9. 9
    Denitrification vs. assimilation: shifting metabolic pathways to enable N recovery from low-strength municipal wastewater.

    Zhang G, Wang S, Li W, Li H, Guo X, Li D, Lv L. · 2026-05-30

    unreviewed
  10. 10
    Glial cells in neuropathic pain.

    Berta T, Khoutorsky A, Xu J, Ji RR. · 2026-05-11

    unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.