Glutamate dehydrogenase
Clinical / pharmacological. Activating mutations: hyperinsulinism-hyperammonaemia syndrome
What it does, reaction by reaction
Oxidative Deamination Amino Acid & Nitrogen Metabolism · Mitochondrial matrix
L-glutamate + NAD⁺ (or NADP⁺) + H₂O ⇌ α-ketoglutarate + NH₄⁺ + NADH (or NADPH) + H⁺
Converts Glutamate NAD+ (or NADP+) H2O into Alpha-ketoglutarate NH4+ NADH (or NADPH) H+
› Notes
Glutamate dehydrogenase catalyzes oxidative deamination in the mitochondrial matrix. NAD⁺ is generally the major oxidant during net hepatic glutamate oxidation, although the enzyme can use NADP⁺; the reaction is reversible and is the principal regulated route for release of free ammonia from glutamate.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
Oxidative Deamination
ADP, GDP; leucine allosterically activates the mammalian enzyme
ATP, GTP; high-energy charge
Glucagon and cortisol increase hepatic amino-acid catabolic/ureagenic capacity indirectly; insulin suppresses net amino-acid catabolism in the fed state
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Metabolic engineering of <i>Escherichia coli</i> for efficient production of d-phenylglycine.
Xiong Y, Shang Z, Lu L, Wang T, Cai G, Shen X, Sun X, Wang J, Yuan Q. · 2026-08-07
open access unreviewed -
2
Investigation of geographical differences among Giardia duodenalis assemblage B populations using diverse haplotypes identified by cloning of PCR amplicons.
Mizuno T, Asih PBS, Lacante SA, Hendarto J, Matsumura T, Bi X, Matey EJ, Syafruddin D, Songok EM, Ichimura H,… · 2026-08-22
unreviewed -
3
N-terminal fusion length: The key to reliable and context-preserving regulatory sequence characterization.
Yang S, Liu Y, Li A, Wang S, Cui J, Liu H, Wang M, Mao Y. · 2026-07-22
open access unreviewed -
4
Real-time NMR analysis of glutamine metabolism for screening anti-cancer agents in living cells.
Lei Y, Huang T, Chai X, Fan X, He S, Liu C, Liu M, Zhang X. · 2026-06-12
open access unreviewed -
5
Engineering nonconventional yeasts to produce carboxylic acids: Advances and Prospects.
Zhang L, Fan Y, Shi W, Zhou X. · 2026-07-16
open access unreviewed -
6
Metabolic regulation of oocyte maturation and early embryo development in mammals.
Rong S, Fu Y, Li Y, Jiang YC, Chen L, Zhao Y, Zhu W, Mu L. · 2026-08-06
open access unreviewed -
7
Diammonium phosphate supplementation in low-protein diets improves nitrogen utilization and feed efficiency without impairing carcass traits or meat quality in finishing pigs.
Zeng X, Tang Y, Li S, Wang Q, Yang H. · 2026-07-02
open access unreviewed -
8
Glutamate metabolic correlation analysis reveals <i>CnP5CS1</i> contributes to 2-acetyl-1-pyrroline accumulation in aromatic coconut.
Ding H, Sun X, Yin J, Luo D, Shi C, Shen X, Liu X, Li J, Iqbal A, Yang Y. · 2026-09-01
open access unreviewed -
9
Clostridioides difficile in West Africa: a systematic review of the limited evidence and key knowledge gaps.
Usuanlele MT, Kabali C, Mbuagbaw L, Loeb M, Mertz D. · 2026-08-18
open access unreviewed -
10
Revisiting gut microbiota-driven ammonia metabolism: from disease burden to physiological adaptation.
Chen H, Wang Z, Huang J, Yu Z. · 2026-08-25
open access unreviewed
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