Glucose-6-phosphate dehydrogenase (G6PD)
Cofactors used
Clinical / pharmacological. G6PD deficiency: oxidative haemolysis, Heinz bodies, bite cells, favism
What it does, reaction by reaction
Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism · Cytosol
Glucose-6-phosphate + NADP+ → 6-phosphoglucono-delta-lactone + NADPH + H+
Converts Glucose-6-phosphate NADP+ into 6-Phosphoglucono-delta-lactone NADPH H+
› Notes
Glucose-6-phosphate dehydrogenase (G6PD) uses NADP+ and is the first, rate-limiting, committed, and irreversible oxidative PPP reaction. It generates the first NADPH and is stimulated by a high NADP+/NADPH ratio.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
An immune-adaptive 3D-printed scaffold promotes endogenous osteogenesis by engineered macrophage capture traps.
Zhu Z, Gu P, Li X, Xiao X, Wang H, Liang J, Fan Y, Sun Y. · 2026-08-14
unreviewed -
2
Key molecular networks underlying retinol's biphasic effects on cell proliferation through multi-omics integrative analysis using genome-scale metabolic modeling.
He P, Xiang G, Yan Y, Zhong J, Liang Y, Shu P, Lu H. · 2026-06-19
open access unreviewed -
3
Lipidomic profiling of PEX11β knockout T-REx 293 cells reveals lipid shifts suggesting potential metabolic perturbations.
Jeng S, Soni M, Kalel VC, Schliebs W, Erdmann R, Schulz F. · 2026-09-17
unreviewed -
4
Metabolic regulation of oocyte maturation and early embryo development in mammals.
Rong S, Fu Y, Li Y, Jiang YC, Chen L, Zhao Y, Zhu W, Mu L. · 2026-08-06
open access unreviewed -
5
Effects of chitin derived from black soldier fly larvae on growth performance, antioxidant capacity, hepatopancreas morphology, intestine microbiota, immune capacity, and lipid metabolism of Pacific white shrimp (<i>Litopenaeus</i> <i>vannamei</i>).
Li X, Chen Y, Chen X, Pu H, Zhang W, Ye T, Gu X, Liao Z, Zhao W, Niu J. · 2026-07-04
open access unreviewed -
6
NOX2/NOX4-associated oxidative stress contributes to G6PD-associated metabolic remodeling and ferroptosis during mice luteolysis.
Li F, Song J, Zou W, Zhang Y, Cheng Y, Zhao H, Yang B, Kuang H. · 2026-09-04
open access unreviewed -
7
Lactylation in influenza a virus infection: Current evidence, knowledge gaps, and future perspectives.
Yan YC, Li Z, He H, Wu M, Yang H, Wei F. · 2026-08-02
open access unreviewed -
8
Psychotherapy vs antidepressants in heart failure: Impact of adherence.
IsHak WW, Hamilton MA, Diniz MA, Mirocha J, Chernoff R, Hedrick R, Aronow H, Darwish T, Messineo G, Pasini M,… · 2026-07-30
unreviewed -
9
Neonatal genetic sequencing as a first-tier option: a real-world clinical implementation study in Northern China.
Mu J, Sun M, Li Y, Li P, Zou H. · 2026-07-09
open access unreviewed -
10
Different treatments regulate starch degradation, ethylene biosynthesis, and energy metabolism involved in the preparation and shelf life of ready-to-eat kiwifruit.
Liu X, Tang S, Ji N, Lei J, Chen C, Zheng P, Liu B, Wang R. · 2026-06-23
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.