Glucose-6-phosphate dehydrogenase (G6PD)
Cofactors used
Clinical / pharmacological. G6PD deficiency: oxidative haemolysis, Heinz bodies, bite cells, favism
What it does, reaction by reaction
Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism · Cytosol
Glucose-6-phosphate + NADP+ → 6-phosphoglucono-delta-lactone + NADPH + H+
Converts Glucose-6-phosphate NADP+ into 6-Phosphoglucono-delta-lactone NADPH H+
› Notes
Glucose-6-phosphate dehydrogenase (G6PD) uses NADP+ and is the first, rate-limiting, committed, and irreversible oxidative PPP reaction. It generates the first NADPH and is stimulated by a high NADP+/NADPH ratio.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Research progress of ferroptosis in gynecological diseases.
Chen W, Zhou W, Liu S. · 2026-06-19
open access unreviewed -
2
Soil-derived microbiota induces T regulatory cells and protect against mouse colitis, metabolic disease, and sepsis.
Szurek EA, Ngo VL, Abo H, Cebula A, Chassaing B, Howard RA, Hart M, Hori S, Weaver CT, Gewirtz AT, Ignatowicz… · 2026-05-24
open access unreviewed -
3
A review of the sirtuins family: pivotal regulators and emerging therapeutic targets in renal fibrosis.
Deng Q, Li C, Luo J, Yin M, Qian S, Li L. · 2026-05-14
open access unreviewed -
4
Ultrasound-guided injection strategies for lateral epicondylitis: a multicenter randomized comparison of corticosteroid, platelet-rich plasma, and ozone.
Raeissadat SA, Khavari Ardestani D, Mousavikhah SE, Bayat M, Babaee M, PourAzin M. · 2026-04-13
open access unreviewed -
5
Microbiota as a modulator of drug response: targeting microbial-drug crosstalk in cancer therapy.
Zhao T, Liu M, Qiu L, Zhang H, Zhang N, Liu Z, Xia Z, Luo P, Huang J, Cheng Q. · 2026-04-10
open access unreviewed -
6
LDH isozymes as targets for cancer therapy.
Hou Y, Zhao Y, He Q, Wang M, Zhang Q. · 2026-03-16
cited 1× open access unreviewed -
7
Association between maternal stress hormone levels during labor induction and the occurrence of neonatal hyperbilirubinemia.
Liu S, Xiao H, Wang Y, Liu H, Qi X, Fang Y, Zhang L. · 2026-02-02
unreviewed -
8
Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.
Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28
cited 1× open access unreviewed -
9
Metabolomic profiling of neat uterine luminal fluid in cows: local enrichment and nutritional modulation.
Sagheer M, Hoorn QA, Maldonado MB, Schalich KM, Ashrafi N, A Mimi R, Graham SF, Selvaraj V, Hansen PJ. · 2026-01-07
cited 3× open access unreviewed -
10
Autophagy and ubiquitination in important swine viral infections: Host defense and viral antagonism.
He Z, Liu M, Xie Q, Lu H, Guo C. · 2025-12-17
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.