Cytosolic, NADP+-dependent malic enzyme
Cofactors used
What it does, reaction by reaction
Fatty Acid Synthesis (De Novo Lipogenesis) Lipid Metabolism · Cytosol
Malate + NADP+ → pyruvate + CO2 + NADPH + H+
Converts Malate NADP+ into Pyruvate CO2 NADPH H+
› Notes
Cytosolic, NADP+-dependent malic enzyme produces NADPH and pyruvate. Pyruvate returns to mitochondria and can be carboxylated to oxaloacetate by pyruvate carboxylase (ATP and biotin required), completing the shuttle; the pentose-phosphate pathway is another major NADPH source.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Comparative Diagnostic Sensitivity of Endoscopic Ultrasound-guided Tissue Acquisition for Hepatocellular Carcinoma Versus Intrahepatic Cholangiocarcinoma.
Takano Y, Tamai N, Noda J, Azami T, Niiya F, Uyama R, Maruoka N, Yamagami T, Nakamura A, Ogawa T, Umemoto T, … · 2026-08-31
open access unreviewed -
2
Transposon-based genome editing of industrial microorganisms: advances, challenges, and prospects.
Zhang Z, Huang Z, Wang Y, Li Z, Wen Z, Gu Y. · 2026-05-29
open access unreviewed -
3
Integrated transcriptome and metabolome reveal <i>Mycoplasma hyopneumoniae</i> -induced lipid accumulation, inflammation, oxidative stress, and energy imbalance in the liver of pigs.
Xue X, Bu Y, Yu C, Li J, Yang J, Gao M, Wang P, Gan Y, Zhang W, Fan S, Zhou R, Yin Z, Zheng X. · 2026-06-03
cited 1× open access unreviewed -
4
Biological-chemical method for synthesizing <i>p</i>-menthane-3,8-diol.
Zuo X, Zhang H, Zhang Z, Ma Y, Zhang C, Lu W. · 2026-05-12
open access unreviewed -
5
Super-enhancer-associated miR-1260b coordinates adipogenesis and metabolic programming in human adipose stem cells.
Li S, Ji S, Yu Z, Liu H, Wu J. · 2026-03-13
open access unreviewed -
6
Multi-omics dissection of metabolic hijacking: Infectious bronchitis virus orchestrates lipid-centric replication through PPAR-TGF-β crosstalk.
Yan K, Wang X, Bo Z, Zhang C, Guo M, Zhang X, Wu Y. · 2026-01-28
cited 1× open access unreviewed -
7
Small regulatory RNAs mediated regulation of virulence and host-pathogen interaction in the Gram-negative ESKAPE pathogens.
Li L, Zhang Z, Zhu H, Cui K, Song X, Wang Z, Chen L, Yu Z, Zhang W, Sun H, Yu Z, Duan Y, Li M. · 2025-12-18
cited 4× open access unreviewed -
8
Research progress on lysine acetylation (Review).
Zhang M, Zhang Y, Yin H, Yan J, Dong Y, Zhao X, Cui T, Lv B, Gao X. · 2026-09-04
open access unreviewed -
9
Deubiquitination of ME1 by OTUD7B promotes aerobic glycolysis of esophageal cancer.
Guan L, Li X, Du Z, Yuan Q, Zhou F, Li X, Xu J, Wang Z, Lv M, Lv L. · 2026-08-11
unreviewed -
10
Characterization of the Middle Ear Microbiome in Meniere's Disease by 16S rRNA Gene Sequencing Compared to Chronic Suppurative Otitis Media
Tao Y, Wang L, Zheng H, Yu L. · 2026-10-07
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.