Glycinamide ribonucleotide (GAR)
Reactions involving Glycinamide ribonucleotide (GAR)
Every recorded step where this molecule takes part
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10-Formyl-THF + glycinamide ribonucleotide (GAR) → formyl-GAR + THF
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GAR → formylglycinamide ribonucleotide (FGAR)
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produced Phosphoribosylamine--glycine ligase (GAR synthetase) Purine De Novo Synthesis (IMP synthesis t… ST-0193
5-PRA → glycinamide ribonucleotide (GAR)
Showing all 3 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Purine De Novo Synthesis (IMP synthesis thr… | → | One-Carbon Metabolism (Folate Cycle) | cross-category |
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Oncolytic virus hijacks GOT1 and pyrimidinosomes to fuel pyrimidine synthesis for replication in tumor cells.
Tang N, Gong Y, Zhao C, Niu Y, Tan L, Song C, Qiu X, Liao Y, Yu S, Ding C, Lin S, Sun Y. · 2026-04-09
open access unreviewed -
2
Click Reactions in Kinetic Target-Guided Synthesis: Progress in the Discovery of Inhibitors for Biological Targets.
Parvatkar PT, Satam N. · 2026-04-01
open access unreviewed -
3
One-Carbon Metabolism and Midbrain Dopaminergic Cells in Lesch-Nyhan Disease.
Alsuwaidi S, Ernst C. · 2025-11-07
open access unreviewed -
4
One-Carbon Metabolism Inhibition Depletes Purines and Results in Profound and Prolonged Ewing Sarcoma Growth Suppression.
Zirpoli S, Copperman N, Patel S, Forrest A, Hou Z, Matherly LH, Loeb DM, Di Cristofano A. · 2025-08-01
cited 2× open access unreviewed -
5
The oncoprotein SET promotes serine-derived one-carbon metabolism by regulating SHMT2 enzymatic activity.
Jiao Z, Zhang M, Ning J, Yao H, Yan X, Wu Z, Wu D, Liu Y, Zhang M, Wang L, Wang D. · 2025-05-08
cited 3× open access unreviewed -
6
Identification and enrichment of potential pathways in the buffy coat of patients with DRE using non-targeted metabolomics integrated with GEO Datasets.
Zhu H, Zheng S, Xie L, Yun Y, Kwan P, Rollo B, Huang H. · 2025-04-26
cited 1× open access unreviewed -
7
Serine starvation suppresses the progression of esophageal cancer by regulating the synthesis of purine nucleotides and NADPH.
Jie H, Wei J, Li Z, Yi M, Qian X, Li Y, Liu C, Li C, Wang L, Deng P, Liu L, Cen X, Zhao Y. · 2025-02-13
cited 3× open access unreviewed -
8
Disruption of purine <i>de novo</i> synthesis pathway impairs membrane homeostasis, intracellular survival, and virulence of <i>Brucella melitensis</i>.
Yang G, Li M, Li Y, Chen S, Qu J, Li J, Wang S, Bao Y, Qi J, Dou Y, Tian M. · 2025-12-16
open access unreviewed -
9
In vivo Testing of Nanotherapeutics for Osteosarcoma Treatment: Translational Challenges and Solutions.
D'Anna G, Hanurry EY, Piperno A, Scala A. · 2025-12-10
cited 2× open access unreviewed -
10
Combating Methotrexate Resistance in Cancer Treatment: A Review on Navigating Pathways and Enhancing Its Efficacy With Fat-Soluble Vitamins.
Kakkadath M, Naidu D, Kanthlal SK, Sharun K. · 2025-04-16
cited 5× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.