What it does, reaction by reaction
1 reactions
Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol
step 3
Irreversible/directional
5-PRA → glycinamide ribonucleotide (GAR)
Converts 5-Phosphoribosylamine into Glycinamide ribonucleotide (GAR)
› Notes
Phosphoribosylamine--glycine ligase (GAR synthetase) catalyzes 5-PRA + glycine + ATP → GAR + ADP + Pi. Mg2+ is required; glycine contributes C4, C5, and N7 of the future purine ring.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
0 entries
No regulation recorded for this enzyme in the source documents.
Recent literature
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