AICAR
Reactions involving AICAR
Every recorded step where this molecule takes part
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10-Formyl-THF + AICAR → formyl-AICAR + THF
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AICAR → 5-formamidoimidazole-4-carboxamide ribonucleotide (FAICAR)
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SAICAR → 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)
Showing all 3 reactions.
Pathway junctions through this molecule
Produced in one pathway, consumed in another
| Produced in | Consumed in | Link | |
|---|---|---|---|
| Purine De Novo Synthesis (IMP synthesis thr… | → | One-Carbon Metabolism (Folate Cycle) | cross-category |
Recent literature
Europe PMC · from cache · sorted by publication date
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1
PLIN3-triggered lipophagic flux releases FFAs to facilitate CSFV propagation.
Li B, Zou L, Sun C, Jiang J, Li S, Wang J, He Y, Qin Y, Zeng S, Song Y, Zeng W, Yi L, Fan S, Chen J, Wu K. · 2026-02-25
open access unreviewed -
2
Targeting mitochondrial quality control in diabetic kidney disease: emerging therapeutic opportunities.
Luo J, Lu F, Cuciureanu M, Xu X, Dong H, Gong M. · 2026-02-03
cited 2× open access unreviewed -
3
Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells.
Vo HVT, Patton GN, Park JS, Kim SJ, Kim N, Lee HJ. · 2026-01-19
cited 2× open access unreviewed -
4
Sub-chronic exposure to lanthanum chloride induces hepatic steatosis via AMPK-dependent lipophagic defects in male zebrafish.
Zhao X, Zhou X, Li K, Wu Q, Sha Y, Xie Z, Zeng P, Qi Z, Niu Q, Li W, Song W. · 2026-07-18
unreviewed -
5
LKB1/ AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene.
Zhu L, Wan C, Li Z, Fan X, Liu D, Jia X, Li H, Zhang J. · 2026-07-16
unreviewed -
6
AMPK activation by AICAR mitigates hypoxic corneal damage through rebuilding energy and metabolic homeostasis.
Yan X, Chen G, Huang Y, Yang S, Guan Y, Cao Z, Li X. · 2026-07-02
unreviewed -
7
Gonadotropin-inhibitory hormone (GnIH) induces glycolipid metabolic dysfunction in porcine ovarian granulosa cells via Wnt and AMPK signaling pathways.
Peng K, Zhang X, Lu M, Zhu H, Song X, Lao J, Wang W, Tang G, Ma J, Li J, Lu Y, Li L, Zhang X, Li Z, Wang Z, L… · 2026-05-07
unreviewed -
8
Robust loading and delivery of functional small RNAs <i>via</i> protein N-myristoylation-induced small extracellular vesicles.
Wang H, Zhang X, Liang Y, Zeng Z, Bi L, Yang Y, Pan J, Dai G, Wu G, Fan W. · 2026-04-13
open access unreviewed -
9
FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis.
Mao L, Dang D, Wang W. · 2026-08-06
unreviewed -
10
Dynamic metabolomics of uterine fluid of laying hens: Key metabolites and pathways governing sperm motility and functional longevity.
Zhang Q, Du H, Ge C, Zhang Z, Yuan J, Li Y, Isa AM, Chen J, Sun Y. · 2026-05-08
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.