unreviewed

Adenylosuccinate lyase (ADSL)

2 reactions · 1 pathways

What it does, reaction by reaction

2 reactions

Purine De Novo Synthesis (IMP synthesis through to AMP/GMP) Nucleotide Metabolism · Cytosol

step 9 Irreversible/directional

SAICAR → 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR)

Converts SAICAR into AICAR

› Notes

Adenylosuccinate lyase catalyzes SAICAR → AICAR + fumarate. This nonhydrolytic elimination releases the aspartate carbon skeleton as fumarate, linking purine synthesis to the tricarboxylic acid cycle.

step 13 Irreversible/directional

Adenylosuccinate → AMP

Converts Adenylosuccinate into AMP

› Notes

Adenylosuccinate lyase catalyzes adenylosuccinate → AMP + fumarate. The reaction completes AMP synthesis and again releases the aspartate carbon skeleton as fumarate.

Showing all 2 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

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