Junction / hub Pathway metabolite unreviewed

Tetrahydrofolate (THF)

Pathways

Reactions involving Tetrahydrofolate (THF)

Every recorded step where this molecule takes part

All 10 Consumed 3 Produced 7

produced Methionine synthase (MTR) Methionine Cycle / Transmethylation (SAM … ST-0173

Homocysteine + 5-methyl-THF → methionine + THF
produced Dihydrofolate reductase (DHFR) One-Carbon Metabolism (Folate Cycle) ST-0160

Dihydrofolate (DHF) + NADPH + H⁺ → tetrahydrofolate (THF) + NADP⁺
produced GAR transformylase (GART) One-Carbon Metabolism (Folate Cycle) ST-0166

10-Formyl-THF + glycinamide ribonucleotide (GAR) → formyl-GAR + THF
produced AICAR transformylase (ATIC) One-Carbon Metabolism (Folate Cycle) ST-0167

10-Formyl-THF + AICAR → formyl-AICAR + THF
produced Methionine synthase (MTR) One-Carbon Metabolism (Folate Cycle) ST-0169

5-Methyl-THF + homocysteine → THF + methionine
produced Dihydrofolate reductase (DHFR) Deoxyribonucleotide Formation (Ribonucleo… ST-0258

DHF → THF
produced Dihydrofolate reductase (DHFR) Pyrimidine De Novo Synthesis (through to … ST-0237

DHF → THF; THF → 5,10-methylene-THF

Showing all 7 reactions.

Produced in one pathway, consumed in another

6 links

Produced in		Consumed in	Link
Deoxyribonucleotide Formation (Ribonucleoti…	→	One-Carbon Metabolism (Folate Cycle)	cross-category
Methionine Cycle / Transmethylation (SAM Cy…	→	Deoxyribonucleotide Formation (Ribonucleoti…	cross-category
Methionine Cycle / Transmethylation (SAM Cy…	→	One-Carbon Metabolism (Folate Cycle)	within category
One-Carbon Metabolism (Folate Cycle)	→	Deoxyribonucleotide Formation (Ribonucleoti…	cross-category
Pyrimidine De Novo Synthesis (through to UM…	→	Deoxyribonucleotide Formation (Ribonucleoti…	within category
Pyrimidine De Novo Synthesis (through to UM…	→	One-Carbon Metabolism (Folate Cycle)	cross-category

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