Orotate
Reactions involving Orotate
Every recorded step where this molecule takes part
-
consumed Orotate phosphoribosyltransferase (UMP synthase domain 1) Pyrimidine De Novo Synthesis (through to … ST-0228
Orotate → orotidine 5′-monophosphate (OMP)
-
Dihydroorotate → orotate
Showing all 2 reactions.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
Systematic metabolic engineering of <i>Escherichia coli</i> for high-level production of pseudouridine via pathway optimization and precursor enhancement.
Song J, Shen W, Xia Y, Zhou L, Zhou Y, Yang H, Chen X. · 2026-04-06
open access unreviewed -
2
Genome-wide Identification of conditionally essential genes supporting <i>Streptococcus suis</i> growth in serum and cerebrospinal fluid.
Juanpere-Borras M, Zhao T, Boekhorst J, Fernandez-Ciruelos B, Sanyal R, Arifa N, Wagenaar T, van Baarlen P, W… · 2025-12-15
cited 1× open access unreviewed -
3
Ion chromatography-ultra-high-resolution mass spectrometry reveals EZH2-driven reprogramming of nucleic acid and protein methylation.
Kaddah MMY, Fan TW, Islam JMM, Lin P, Cassel TA, Cunningham R, Brown T, Higashi RM, Lane AN. · 2026-05-13
unreviewed -
4
Unveiling metabolic mechanisms of aroma-active compounds during yogurt fermentation through volatilomics, sensomics, and untargeted metabolomics analysis.
Han H, Wang Y, Meng T, Hou B, He J, Li B, Kong C, Wang B. · 2026-05-30
unreviewed -
5
Mitochondrial complex I inhibition remodels the PDAC fibrotic microenvironment via LOXL2 suppression to potentiate chemo-immunotherapy.
Qin Z, Xu Y, Wang Y, Ma J, Zou J, Wang Y, Zhang K, Qiu J, Ju R, Guo L. · 2026-07-15
unreviewed -
6
<i>Pestiviruses</i> utilize pyrimidine metabolism to regulate mitophagy for viral replication.
Zhao B, Chen J, Cheng Y, Li Y, Zhong L, Chen J, Bi X, Bai J, Dai Q, Ye Y, Zou L, Wang L, Zhou B. · 2026-04-20
unreviewed -
7
Mitochondrial ACSS1 links acetate metabolism to pyrimidine biosynthesis in nutrient-stressed B-cell lymphomas.
Basappa J, Goldman AR, Lobello C, Wang S, Rushmore D, Melnikov O, Sen NV, Mallikarjuna VS, Jain P, Edalati M,… · 2026-04-07
unreviewed -
8
DHODH-Mediated Suppression of Ferroptosis Supports Radioresistance and Represents a Therapeutic Vulnerability in Lung Cancer.
Mao C, Wu S, Rajacharya GH, Wang M, Lu Z, Huo D, Yan Y, Chen X, Lei G, Xu Z, Li Q, Sun M, Zhao X, Zhuang L, J… · 2026-07-01
unreviewed -
9
Plasma metabolomics reveals distinct responses to acute and chronic heat stress in broilers.
Papanikolaou A, Kampschoer EMJM, Matthijs MGR, Schonewille JT, Khempaka S, Berkers CR, Zaal EA. · 2026-03-28
open access unreviewed -
10
Alterations of Plasma Metabolites Associated with Sickle Cell Trait.
Cai Y, Surapaneni A, Vasconcelos AG, Johnson M, Hsu L, Sun W, Kooperberg C, Yu B, Yeo WJ, Auer PL, Grams ME, … · 2026-02-27
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.