Dihydroorotate dehydrogenase (DHODH)
Cofactors used
Clinical / pharmacological. Target of leflunomide/teriflunomide; only mitochondrial step of pyrimidine synthesis
What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
Dihydroorotate → orotate
Converts Dihydroorotate into Orotate
› Notes
DHODH catalyzes L-dihydroorotate + ubiquinone (CoQ) → orotate + ubiquinol (CoQH2). Flavin mononucleotide (FMN) is the redox cofactor; mitochondrial electron transport regenerates oxidized CoQ. This is the only mitochondrial-associated step of the pathway.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Nothing is fetched until you ask, so the page stays fast and the request is yours rather than automatic.
Europe PMC · ten most recent, newest first