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Connectivity map

Each node is a pathway. An edge means a molecule produced by one is consumed by the other. Common carriers are excluded, otherwise everything joins to everything.

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Network

12 pathways · 14 edges
Galactose Metabolism → Glycogenesis (Glycogen Synthesis): Glucose, Glucose-1-phosphate, Glucose-6-phosphate, UDP-glucose Glycogenesis (Glycogen Synthesis) → Galactose Metabolism: Glucose-1-phosphate, UDP-glucose Galactose Metabolism → Glycolysis: Glucose, Glucose-6-phosphate Galactose Metabolism → Glycogenolysis (Glycogen Breakdown): Glucose-1-phosphate, Glucose-6-phosphate Galactose Metabolism → Anaerobic Glycolysis / Lactic Acid Fermentation: Glucose, Glucose-6-phosphate Galactose Metabolism → Uronic Acid Pathway: Glucose-1-phosphate, UDP-glucose Glycogenolysis (Glycogen Breakdown) → Galactose Metabolism: Glucose-1-phosphate Galactose Metabolism → Gluconeogenesis: Glucose-6-phosphate Galactose Metabolism → Pentose Phosphate Pathway (Oxidative and Non-oxidative phases): Glucose-6-phosphate Galactose Metabolism → Sorbitol / Polyol Pathway: Glucose Galactose Metabolism → Sphingolipid Synthesis: UDP-glucose Galactose Metabolism → Cori Cycle (lactate shuttle): Glucose Uronic Acid Pathway → Galactose Metabolism: UDP-glucose Sphingolipid Degradation (Lysosomal) → Galactose Metabolism: Galactose Cori Cycle (lactate shuttle) Carbohydrate Metabolism 1 connection · Terminal Cori Cycle (lactate shuttle) Galactose Metabolism Carbohydrate Metabolism 14 connections · Hub Galactose Metabolism Gluconeogenesis Carbohydrate Metabolism 1 connection · Terminal Gluconeogenesis Glycogenesis (Glycogen Synthesis) Carbohydrate Metabolism 2 connections · Peripheral Glycogenesis (Glycogen Synthe… Glycogenolysis (Glycogen Breakdown) Carbohydrate Metabolism 2 connections · Peripheral Glycogenolysis (Glycogen Brea… Glycolysis Carbohydrate Metabolism 1 connection · Terminal Glycolysis Pentose Phosphate Pathway (Oxidative and Non-oxidative phases) Carbohydrate Metabolism 1 connection · Terminal Pentose Phosphate Pathway (Ox… Sorbitol / Polyol Pathway Carbohydrate Metabolism 1 connection · Terminal Sorbitol / Polyol Pathway Uronic Acid Pathway Carbohydrate Metabolism 2 connections · Peripheral Uronic Acid Pathway Sphingolipid Degradation (Lysosomal) Lipid Metabolism 1 connection · Terminal Sphingolipid Degradation (Lys… Sphingolipid Synthesis Lipid Metabolism 1 connection · Terminal Sphingolipid Synthesis Anaerobic Glycolysis / Lactic Acid Fermentation Energy Metabolism & Cellular Respiration 1 connection · Terminal Anaerobic Glycolysis / Lactic…

Circles — how connected a pathway is

  • Hub Connects to a large share of the map. Disturb one of these and the effect travels widely.
  • Connector Several links in and out. Typical of a pathway that both consumes and supplies intermediates.
  • Peripheral A handful of links, usually to close relatives within the same category.
  • Terminal One or two links. Either a short pathway or one the source documents describe in isolation.

Lines — what the connections mean

  • Violet joins two different categories — for example carbohydrate metabolism feeding lipid metabolism. These are the interesting ones.
  • Grey joins two pathways inside the same category.
  • Thickness is the number of different molecules shared. A thick line means the two pathways trade several intermediates, not just one.
› How to read this map

Think of each circle as a factory and each line as a delivery route. A line is drawn from one pathway to another when the first one makes a molecule that the second one uses. So the map is not about which pathways look similar; it is about which ones hand material to each other.

Big violet circles are the busy junctions. They sit in the middle of many deliveries, which is usually why a defect in one of them shows up in several organ systems at once. Small grey circles at the edge either are short pathways or are described on their own in the source documents, so they have few recorded hand-offs.

Common carriers such as ATP, NAD+ and water are deliberately left out. They take part in almost every reaction, so including them would connect everything to everything and the picture would say nothing. What remains are the specific intermediates.

Two cautions. A line means a connection exists somewhere in this dataset, not that material actually flows that way in a given tissue at a given moment — check the compartment and tissue on each pathway page. And a missing line may only mean the source documents did not record that step, not that biology lacks it.

Hover any circle for its name and connection count, hover any line for the molecules it carries, and click either to open the pathway behind it.

Filter by category

Carbohydrate Metabolism Lipid Metabolism Amino Acid & Nitrogen Metabolism Nucleotide Metabolism Energy Metabolism & Cellular Respiration Cofactor & Vitamin Metabolism Xenobiotic & Drug Metabolism

Junction detail

Directed: produced in the first pathway, consumed in the second

14 links
Galactose Metabolism Glycogenesis (Glycogen Synthesis) within

Glucose, Glucose-1-phosphate, Glucose-6-phosphate, UDP-glucose

Glycogenesis (Glycogen Synthesis) Galactose Metabolism within

Glucose-1-phosphate, UDP-glucose

Galactose Metabolism Glycolysis within

Glucose, Glucose-6-phosphate

Galactose Metabolism Glycogenolysis (Glycogen Breakdown) within

Glucose-1-phosphate, Glucose-6-phosphate

Galactose Metabolism Anaerobic Glycolysis / Lactic Acid Ferm… cross-category

Glucose, Glucose-6-phosphate

Galactose Metabolism Uronic Acid Pathway within

Glucose-1-phosphate, UDP-glucose

Glycogenolysis (Glycogen Breakdown) Galactose Metabolism within

Glucose-1-phosphate

Galactose Metabolism Gluconeogenesis within

Glucose-6-phosphate

Galactose Metabolism Pentose Phosphate Pathway (Oxidative an… within

Glucose-6-phosphate

Galactose Metabolism Sorbitol / Polyol Pathway within

Glucose

Galactose Metabolism Sphingolipid Synthesis cross-category

UDP-glucose

Galactose Metabolism Cori Cycle (lactate shuttle) within

Glucose

Uronic Acid Pathway Galactose Metabolism within

UDP-glucose

Sphingolipid Degradation (Lysosomal) Galactose Metabolism cross-category

Galactose

Showing all 14 junctions.