Cytosolic HMG-CoA synthase (HMGCS1)
Cofactors used
What it does, reaction by reaction
Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER
Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH
Converts Acetoacetyl-CoA Acetyl-CoA H2O into HMG-CoA CoA-SH
› Notes
Cytosolic HMG-CoA synthase (HMGCS1) forms 3-hydroxy-3-methylglutaryl-CoA. It is distinct from mitochondrial HMGCS2 of ketogenesis.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
3D-printed niche-matched GelMA-dECM bioinks rewire lipid metabolic reprogramming and chemosensitization in pancreatic ductal adenocarcinoma.
Zhu B, Yang T, Chang M, Li Y, Wu D, Yan J, Guo Q, Wan J, Guo Y, Lu Y. · 2026-08-20
unreviewed -
2
Panax quinquefolius saponins promote remyelination via orchestrating HMGCS1-NPC1-MAL-mediated lipid metabolism and rebalancing JAK-STAT signaling in a cuprizone-induced demyelination model.
Huang J, Sun L, Yue L, Xu L, Liu H, Ma P, Xiao P. · 2026-07-04
unreviewed -
3
Taurochenodeoxycholic acid alleviates MPP<sup>+</sup>/MPTP-induced neurotoxicity in vitro and in vivo by suppressing ferroptosis via TGR5/cGAS/STING signaling pathway.
Wang L, Ni Y, Wang X, Ma Y, Chang Y, Chen L, Yu L, He Z, Li F. · 2026-06-30
cited 1× open access unreviewed -
4
Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.
Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01
open access unreviewed -
5
Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.
Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14
cited 40× open access unreviewed -
6
Cell Surface Markers Identify Astrocyte Subpopulations in the Adult Hippocampus With a Heterogeneous Response to Aging.
Casares-Crespo L, Cano-Jaimez M, Anta R, Ripollés-Boix A, Robledo-Yagüe F, Zúñiga-Trejos S, Mira H. · 2026-11-01
open access unreviewed -
7
Integrated Analysis of Metabolomics and Proteomics Reveals the Potential Mechanism of Lung Injury Induced by Di(2-Ethylhexyl) Phthalate.
Wu S, Wang B, Zhang N, Feng C, Wang H, Zheng Q, Kang R, Niu X, Wang X, Guo X, Zhang S. · 2026-03-17
unreviewed -
8
Tumor cell-intrinsic stress states drive sensitivity to CAR T cell therapy in pancreatic cancer.
Fröse J, Chen E, Whittaker CA, Leclerc P, Doherty S, Langenbucher A, Shao J, Hellinger RD, Goulet D, Tammela … · 2026-10-02
open access unreviewed -
9
Cholesterol 25-Hydroxylase Deficiency Provides an Optimal and Durable Protective T Helper 1 Immunity via Interleukin-12-Interleukin-2 Axis in BCG-Vaccinated Mice.
Kim H, Choi E, Kwon KW, Choi HH, Kim K, Jung W, Shin SJ. · 2026-09-30
open access unreviewed -
10
Adaptation to heat stress by diversification of the vertebrate heat shock transcription factor family.
Takii R, Fujimoto M, Nakai A. · 2026-10-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.