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unreviewed

Cytosolic HMG-CoA synthase (HMGCS1)

1 reactions · 1 pathways

Cofactors used

CoA-SH · B5 (Pantothenic acid) H2O

What it does, reaction by reaction

1 reactions

Cholesterol Biosynthesis (Mevalonate Pathway) Lipid Metabolism · Cytosol + ER

step 2 Irreversible/directional

Acetoacetyl-CoA + acetyl-CoA + H2O → HMG-CoA + CoA-SH

Converts Acetoacetyl-CoA Acetyl-CoA H2O into HMG-CoA CoA-SH

› Notes

Cytosolic HMG-CoA synthase (HMGCS1) forms 3-hydroxy-3-methylglutaryl-CoA. It is distinct from mitochondrial HMGCS2 of ketogenesis.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Panax quinquefolius saponins promote remyelination via orchestrating HMGCS1-NPC1-MAL-mediated lipid metabolism and rebalancing JAK-STAT signaling in a cuprizone-induced demyelination model.

    Huang J, Sun L, Yue L, Xu L, Liu H, Ma P, Xiao P. · 2026-07-04

    unreviewed
  2. 2
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  3. 3
    Gut microbiota metabolic reprogramming drives the development of metabolic diseases in the host.

    Wang Y, Huang B, Wei X, Guan Y, Li L, Zheng Y, Sun W. · 2026-03-14

    cited 10× open access unreviewed
  4. 4
    8-Chloroadenosine suppresses hepatocellular carcinoma progression via ADAR1/PPARγ axis-mediated lipid metabolism.

    Liu J, Zhao Y, Gong X, Yuan L, Yang S, Jian W, Yan H, Chen H, Yang Z, Sun Y, Gu T, Lu H, Zhao H, Tu Z. · 2025-09-26

    open access unreviewed
  5. 5
    Cycloleucine disturbs functions of porcine Sertoli cell line via modulating gene expression and metabolism.

    Yang CX, Fang T, Wang F, Du ZQ. · 2026-05-09

    unreviewed
  6. 6
    GPR146 Deficiency Enhances Microglial Phagocytosis and Blood-Brain Barrier-Associated Markers in an Acute Amyloid-β Model.

    Yang S, Li Y, Guo Y, Li Y, Li M, Li H, Zhang Y. · 2026-08-05

    unreviewed
  7. 7
    Yin Yang 1 Specifically Supports the Development of Olig2 Positive Cerebellar Astrocytes.

    Zarei-Kheirabadi M, Tyc KM, Dain L, Kheirabadi MA, Hanco J, Mockenhaupt K, Munir S, McQuiston A, Singh SK, Ko… · 2026-08-01

    open access unreviewed
  8. 8
    Sterol regulatory element‑binding proteins: Master regulators of lipid metabolic reprogramming in cancer and emerging therapeutic targets (Review).

    Liu Q, Wang R, Li Z, Liu Y, Wu L, Zhao Y, Yang J. · 2026-06-05

    open access unreviewed
  9. 9
    Proteomic profiling reveals novel insights into hypercortisolism adrenal adenomas.

    Shi X, Yang Y, He C, Xiong Y, Zhang W, Du M, Chen Z, Yin J, Liu Y, Qi S, Wang Y, Li H, Wang X, Liu Q, Li J, H… · 2026-07-08

    unreviewed
  10. 10
    Targeting lung cancer with tanshinones: Current mechanistic evidence and emerging opportunities (Review).

    Guo Z, Li X, Suo P, Lin Z, Liu R, Chi C. · 2026-05-29

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.