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unreviewed

10-Formyl-THF synthetase

1 reactions · 1 pathways

Cofactors used

ATP Pi THF (folate) · B9 (Folate)

What it does, reaction by reaction

1 reactions

One-Carbon Metabolism (Folate Cycle) Amino Acid & Nitrogen Metabolism · Cytosol + mitochondrion

step 5 Irreversible

THF + formate + ATP ⇌ 10-formyl-THF + ADP + Pᵢ

Converts Tetrahydrofolate (THF) Formate ATP into 10-Formyl-THF ADP Pi

› Notes

10-Formyl-THF synthetase activity of MTHFD1 activates formate onto THF. ATP is consumed; in the direction of formate incorporation this is an essentially irreversible, energy-coupled reaction.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Influence of <i>MTHFD1L</i> variants on the susceptibility to hypertension in the Chinese Han population.

    Li Q, Wang L, Li X, Xie P, Zhang Y, Zhou X, Ding Y, Tong S. · 2026-04-07

    open access unreviewed
  2. 2
    MTHFD1 Deficiency in Two Unrelated Children: Highlights on Phenotypic Spectrum and Response to Folic Acid Therapy.

    Altammar F, Elsayed H, Elshinawy M, Al-Herz W. · 2026-06-16

    unreviewed
  3. 3
    Low folate status and related polymorphisms are associated with lower sperm quality in healthy males: The Lifestyle and Environmental Determinants of Seminogram and Other Male Fertility-Related Parameters (Led-Fertyl) cross-sectional study.

    Eigbefoh-Addeh A, Salas-Huetos A, Ramos-Rodríguez C, Santos-Calderón LA, Agarwal R, Salas-Salvadó J, Babio N,… · 2026-06-06

    unreviewed
  4. 4
    Exploring potential biomarkers of diffuse large B-cell lymphoma through multi-dimensional data.

    Li C, Han X, Hu X, Du S, An P, Wang D. · 2026-02-25

    unreviewed
  5. 5
    LncPTEC mediated homocysteine accumulation elevates oxidative stress via UBQLN1-dependent MTHFD1 ubiquitination in DKD.

    Wang Q, Wu T, Li P, Zha H, Wu K, Liu H, Peng R, Peng X, Lin Z, Lv D, Liao X, Sun Y, Zhang Z. · 2026-07-07

    unreviewed
  6. 6
    Methionine Synthase Interacts With the Methionine Adenosyl-Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus.

    Jeandel M, Alberto JM, Baspinar O, Robert A, Dreumont N, Alsahly Z, Meyre D, Guéant JL, Coelho D. · 2026-07-01

    open access unreviewed
  7. 7
    A mathematical model of folate-mediated one-carbon metabolism in Down syndrome.

    Piovesan A, Poluzzi D, Ramacieri G, Locatelli C, Antonaros F, Vione B, Caracausi M, Pelleri MC, Marchetti L. · 2026-06-26

    unreviewed
  8. 8
    Integrating Genome-Scale Metabolic Modeling with Machine Learning Improves Gene Essentiality Prediction in Triple-Negative Breast Cancer.

    Kim BK, Gu C, Farh ME, Ryu JY. · 2026-06-03

    open access unreviewed
  9. 9
    Targeting NFATc1-regulated MTHFD2 one-carbon metabolism to suppress sustained T-cell-mediated inflammation in rheumatoid arthritis.

    Manolakou T, Shen J, Boddul S, Samiotaki M, Panagias MA, Sentis G, Silva TA, Argyriou A, Nikolopoulos D, Sanj… · 2026-06-10

    open access unreviewed
  10. 10
    Patterns of miRNA Expression in Primary and Metastatic Wilms Tumor.

    Csók Á, Micsik T, Magyar Z, Tornóczky T, Kuthi L, Kabai AB, Szirák K, Szilágyi M, Csóka M, Ottóffy G, Soltész… · 2026-06-10

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.