Complex II (succinate dehydrogenase)
Clinical / pharmacological. SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate
What it does, reaction by reaction
Electron Transport Chain (Complexes I–IV) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
Succinate + Q → fumarate + QH2
Converts Succinate into Fumarate Ubiquinol (CoQH2)
› Notes
Required cofactors: enzyme-bound FAD, Fe–S centers, heme b, and ubiquinone. Complex II pumps 0 H+; because FADH2-derived electrons enter at the Q pool and bypass Complex I, they yield less ATP than NADH-derived electrons. Other mitochondrial flavoproteins, including glycerol-3-phosphate dehydrogenase and electron-transfer flavoprotein:ubiquinone oxidoreductase, also feed electrons to Q.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Unveiling the role of air pollution in diabetic kidney disease: an integrated study combining network toxicology, machine learning, and Mendelian randomization.
Kang Y, Jin Q, Li S, Lv Y, Wang X, Jin X, Zhou M, Li D, Lv J, Zheng H, Wang Y. · 2026-05-24
open access unreviewed -
2
Jujuboside A induces bladder cancer cell apoptosis by inhibiting ATP1A2-mediated mitochondrial energy metabolism regulation.
Zhu M, Liu Y, Jia Y, Ren L, An S, Wang Y. · 2026-01-14
open access unreviewed -
3
The Role of the Surgical Pathologist in the Recognition of Hereditary SDH-Deficient Tumor Syndromes.
Juhlin CC, Mete O. · 2026-06-12
unreviewed -
4
Protection Against Periodontitis by Improving Mitochondrial Function in Diabetes.
Onizuka S, Shinjo T, Ishikado A, Wu IH, Ohsugi Y, Jangolla SVT, Li Q, Park K, Fu J, Yu MG, Li Q, Hasturk H, V… · 2026-07-01
unreviewed -
5
ROMO1 and mitochondrial complex II/SDH are required for spare respiratory capacity and glucose homeostasis in mice.
Wells L, Yang Q, Iorio C, Peragerasingam M, Campbell Z, Ng AC, Reeks C, Yee SP, Screaton RA. · 2026-04-17
open access unreviewed -
6
Investigating the relationship between ATP synthase and the TCA cycle by crosslinking mass spectrometry.
Pérez Pañeda L, Misic J, Kadavá T, Larsson NG, Heck AJR. · 2026-06-23
open access unreviewed -
7
Short-term high-fat feeding induces muscle-type-specific signaling adaptations in skeletal muscle of male rats.
Tsutaki A, Imagita H, Yoshida A. · 2026-06-01
open access unreviewed -
8
Influence of Hypothermic Machine Perfusion on Markers of Oxidative Stress and Early Tubular Injury in Rat Donor Kidneys Before Transplantation.
LeGrand C, Bhattarai D, Sharma A, McGraw MK, Gokden N, MacMillan-Crow LA, Parajuli N. · 2026-04-07
open access unreviewed -
9
Therapeutic Potential of Cucurbitacin I in Colon Adenocarcinoma Is Mediated by Modulation of SDHA Expression.
Zhao D, Zhang X, Xiao W, Lin Y, Wu Z, Tang X, Cheng Q, Feng P, Chen W. · 2026-06-01
open access unreviewed -
10
MRPS22 variants alter mitochondrial ribosome assembly in patients with leukodystrophy, movement disorder and intellectual impairment.
Glasgow RIC, Lennartsson F, Arnardottir S, Shiriaev DI, Correia SP, Moedas M, Peña-Pérez L, Paucar M, Naess K… · 2026-06-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.