Complex II (succinate dehydrogenase)
Clinical / pharmacological. SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate
What it does, reaction by reaction
Electron Transport Chain (Complexes I–IV) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
Succinate + Q → fumarate + QH2
Converts Succinate into Fumarate Ubiquinol (CoQH2)
› Notes
Required cofactors: enzyme-bound FAD, Fe–S centers, heme b, and ubiquinone. Complex II pumps 0 H+; because FADH2-derived electrons enter at the Q pool and bypass Complex I, they yield less ATP than NADH-derived electrons. Other mitochondrial flavoproteins, including glycerol-3-phosphate dehydrogenase and electron-transfer flavoprotein:ubiquinone oxidoreductase, also feed electrons to Q.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Unveiling the role of air pollution in diabetic kidney disease: an integrated study combining network toxicology, machine learning, and Mendelian randomization.
Kang Y, Jin Q, Li S, Lv Y, Wang X, Jin X, Zhou M, Li D, Lv J, Zheng H, Wang Y. · 2026-05-24
open access unreviewed -
2
Jujuboside A induces bladder cancer cell apoptosis by inhibiting ATP1A2-mediated mitochondrial energy metabolism regulation.
Zhu M, Liu Y, Jia Y, Ren L, An S, Wang Y. · 2026-01-14
open access unreviewed -
3
Acanthamoeba ATP synthase structure reveals the TCA cycle is tethered to OXPHOS.
Fry MY, Luce BE, Stefely JA, Chen MZ, Deng FG, Issa TM, MitoCarta Tree of Life Consortium, Calvo SE, Samuelso… · 2026-10-01
open access unreviewed -
4
Coumarin-Based Antifungal Leads: Design, Synthesis, Mechanistic Insights, and Synergistic Activity.
Chang X, Du Q, Ma X, Zhang J. · 2026-10-01
open access unreviewed -
5
Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.
Ducharme JB, Schonk MM, Gutierrez-Monreal MA, Ferreira LF, Esser KA, Judge AR, Judge SM. · 2026-10-01
open access unreviewed -
6
Coordinated regulation of the metaboproteome by Hsp90 chaperones controls metabolic plasticity.
Perez RF, Mochi GL, Burkacki JK, Zoccoli-Rodriguez V, Arcadi LD, Backe SJ, Wilmore JR, Woodford MR. · 2026-09-10
open access unreviewed -
7
Amyloid-Forming Amylin Secreted by the Pancreas Promotes Hypoxia-Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis.
Knapton AE, Verma N, Kotiya D, Sowton AP, Thackray BD, Holzner LMW, Darwin PM, Despa S, Despa F, Murray AJ. · 2026-09-04
open access unreviewed -
8
Mitochondria-to-plasma-membrane H<sub>2</sub>O<sub>2</sub> signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells.
Klöppel E, Engstová H, Duspiva P, Tauber J, Mozheitova O, Jabůrek M, Ježek P. · 2026-07-16
open access unreviewed -
9
Effects of copper overload on mitochondrial parameters in GBM-1, U-87 MG, and C6 glioma cell lines.
Tassinari G, de Souza LA, Aguiar de Souza N, Radowitz Mendonça Y, Stoeberl L, Silveira de Melo M, Nazari EM, … · 2026-07-25
open access unreviewed -
10
Toxicity of a novel acaricide, bisulflufen, to the two-spotted spider mite Tetranychus urticae.
Li HJ, Chen JC, Peng B, Gong YJ, Wei SJ. · 2026-07-07
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.