Complex II (succinate dehydrogenase)
Clinical / pharmacological. SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate
What it does, reaction by reaction
Electron Transport Chain (Complexes I–IV) Energy Metabolism & Cellular Respiration · Inner mitochondrial membrane
Succinate + Q → fumarate + QH2
Converts Succinate into Fumarate Ubiquinol (CoQH2)
› Notes
Required cofactors: enzyme-bound FAD, Fe–S centers, heme b, and ubiquinone. Complex II pumps 0 H+; because FADH2-derived electrons enter at the Q pool and bypass Complex I, they yield less ATP than NADH-derived electrons. Other mitochondrial flavoproteins, including glycerol-3-phosphate dehydrogenase and electron-transfer flavoprotein:ubiquinone oxidoreductase, also feed electrons to Q.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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