1-alpha-hydroxylase (CYP27B1)
Cofactors used
Clinical / pharmacological. Vitamin D-dependent rickets type 1; stimulated by PTH, suppressed by FGF-23
What it does, reaction by reaction
Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria
25-Hydroxyvitamin D -> 1,25-dihydroxyvitamin D (calcitriol)
Converts 25-Hydroxyvitamin D (calcidiol) into 1,25-Dihydroxyvitamin D
› Notes
Rate-limiting and tightly regulated step, in the proximal renal tubule: up-regulated by PTH and hypophosphataemia, suppressed by FGF-23 and by calcitriol itself.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
-
1
The interplay between vitamin D status and exerkine signaling: implications for exercise adaptation in athletes: narrative review.
Kim DH. · 2026-05-23
open access unreviewed -
2
Metabolic control of macrophages in coronavirus disease 2019.
An L, Xu H, Fan Q, Lu M, Sun D. · 2025-12-26
open access unreviewed -
3
Therapeutic potential and pathophysiological role of vitamin D in cerebral cavernous malformations: Systematic review of preclinical and clinical evidence.
Alomari O, Eyvazova H, Yılmaz BN, Hamamreh R, Alomari T, Hatip A, Reiter RJ. · 2026-06-21
unreviewed -
4
Vitamin D and antimicrobial peptides in skin health and disease: Mechanisms and therapeutic potential.
Gao H, Zhu J, Chen Z, Wang G. · 2026-06-11
open access unreviewed -
5
Local vitamin D<sub>3</sub> bioactivation in oral tissue, from inactive to influential: A narrative review.
Andrukhov O, Hilberath S, Holzmann M, Laky M, Behm C. · 2026-06-08
unreviewed -
6
Effects of vitamin D<sub>3</sub> on embryonic development, transcripts of genes encoding reproductive hormones, and its active metabolism in common carp (Cyprinus carpio L.).
Suder A, Szczygieł J, Kowalik-Chanek K, Drąg-Kozak E, Łuszczek-Trojnar E, Grzesiak M, Socha M. · 2026-08-13
unreviewed -
7
Mechanistic Insights into Milk Minerals Driving Bone Development and Mineralization in Growing Rats.
Peng Y, Zhou Y, Riis SB, Yin J, Han M, Wen Z, Ye W, Liu X, Shi W, Wang X, Luo J, Xu Y. · 2026-08-06
unreviewed -
8
Endometrial Vitamin D Signaling and Immune Escape in Recurrent Pregnancy Loss.
Voros C, Chatzinikolaou F, Papadimas G, Papapanagiotou I, Zagorianakou N, Gunes AC, Koulakmanidis AM, Karpouz… · 2026-08-03
unreviewed -
9
Effects of fine-to-coarse limestone ratio on performance, egg quality, bone traits, and renal CYP27B1 protein abundance in peak and aged Lohmann Brown laying hens.
Pagnussatt H, de Oliveira CH, Valentim JK, Nunes RV, Tavernari FC, Vieira GL, de Honório BA, Calderano AA. · 2026-05-01
open access unreviewed -
10
Identification of 19 Pathogenic Variants in a Clinically Heterogeneous Cohort With Suspected Inborn Errors of Metabolism.
Mansoor S, Abid S, Imran M, Malik MI, Ali Q, Hussain S, Ali HA, Masood Y, Choudhry S, Qamar R, Azam M. · 2026-04-13
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.