1-alpha-hydroxylase (CYP27B1)
Cofactors used
Clinical / pharmacological. Vitamin D-dependent rickets type 1; stimulated by PTH, suppressed by FGF-23
What it does, reaction by reaction
Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria
25-Hydroxyvitamin D -> 1,25-dihydroxyvitamin D (calcitriol)
Converts 25-Hydroxyvitamin D (calcidiol) into 1,25-Dihydroxyvitamin D
› Notes
Rate-limiting and tightly regulated step, in the proximal renal tubule: up-regulated by PTH and hypophosphataemia, suppressed by FGF-23 and by calcitriol itself.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Biomaterials at the interface of bone-derived factors and inter-organ communication: Current evidence and future perspectives.
Ji L, Zhu F, Wang X, Wang J, Liu C. · 2026-07-13
open access unreviewed -
2
The interplay between vitamin D status and exerkine signaling: implications for exercise adaptation in athletes: narrative review.
Kim DH. · 2026-05-23
open access unreviewed -
3
Metabolic control of macrophages in coronavirus disease 2019.
An L, Xu H, Fan Q, Lu M, Sun D. · 2025-12-26
open access unreviewed -
4
Burosumab as bridging therapy in autosomal dominant hypophosphatemic rickets with femoral fracture nonunion and iron deficiency.
Rakusa M, Kocjan T. · 2026-09-15
open access unreviewed -
5
Characterization of a CYP107 family vitamin D<sub>3</sub> carbon-25 hydroxylase; insights toward vitamin D<sub>3</sub> recognition by a cytochrome P450.
Jensen LJ, Estrada DF. · 2026-08-26
unreviewed -
6
Gene-level variability, pathway-level convergence: A systems view of vitamin D signaling.
Irazoqui AP, Buitrago CG. · 2026-07-08
unreviewed -
7
Vitamin D: Physiology, Pharmacology and Clinical Evidence for Supplementation—A Narrative Review
Virtanen J. · 2026-10-08
open access unreviewed -
8
The role of vitamin D signalling in β cell apoptosis: a systematic review.
Li D, Norris N, An Y, Gunton JE. · 2026-10-01
open access unreviewed -
9
Cyp27b1 Deficiency Impairs Ovarian Development Through Disrupted 1,25(OH)<sub>2</sub>D<sub>3</sub> Regulation of Lipid Metabolism and Redox Homeostasis.
Yang G, Zhang Y, Huang Y, Bayir A, Wang C. · 2026-10-01
unreviewed -
10
Bone <i>FGF23</i> expression and renal regulatory responses to excess phosphate consumption by juvenile swine.
Grez-Capdeville M, Kokinos BP, Amundson LA, Crenshaw TD. · 2026-08-08
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.