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rate-limiting unreviewed

CTP synthetase

1 reactions · 1 pathways

Cofactors used

ATP H2O Pi UTP

What it does, reaction by reaction

1 reactions

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)

step 9 Irreversible/directional

UTP → CTP

Converts UTP into CTP

› Notes

CTP synthetase catalyzes UTP + glutamine + ATP + H2O → CTP + glutamate + ADP + Pi. ATP activates UTP, and ammonia produced by the glutaminase domain is transferred to the synthase domain; this is the committed and regulatory step of CTP formation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP)

Accelerated by

UTP and glutamine availability; polymerization into cytoophidia can modulate activity

Inhibited by

CTP (feedback inhibition); glutamine limitation

Hormonal control

Expression increases in proliferating cells; no canonical acute endocrine regulator.

Recent literature

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Europe PMC · from cache · sorted by publication date

  1. 1
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  2. 2
    Inosine monophosphate dehydrogenases are key players for functional development in Arabidopsis.

    Dörfer E, Sadeghi Z, Frick V, Ebel K, Heide A, Niehoff T, Zehner S, Fischer L, Witte CP, Herde M, Möhlmann T. · 2026-08-01

    unreviewed
  3. 3
    AP-3 and the V-ATPase modulate CTP synthase assembly through spatial association at the yeast vacuole.

    McCright M, Leih M, Nack A, Angers CG, Merz AJ, Odorizzi G. · 2026-07-27

    unreviewed
  4. 4
    Integrative role of CTPS cytoophidia in polyploid tissue growth and nutrient adaptation.

    Hong J, Li J, Zhang Y, Wang J, Li C, Liu JL, Liu J. · 2025-04-27

    unreviewed
  5. 5
    DNA Methylation of Pharmacologic and Leukemia-Related Genes Predicts Clinical Outcomes in Pediatric Acute Myeloid Leukemia.

    Alshameri N, Marchi F, Cao X, Rubnitz JE, Ribeiro RC, Meshinchi S, Pounds SB, Lamba JK. · 2026-07-31

    unreviewed
  6. 6
    Deciphering the impact of <i>SNAI1</i> gene on renal tubular cell proteome, nucleolar stress, ribosome biogenesis, senescence, DNA damage response, and focal adhesion dynamics.

    Kanlaya R, Nonthawong K, Suntivichaya M, Yoodee S, Thongboonkerd V. · 2025-11-10

    open access unreviewed
  7. 7
    RASGRP1 Deficiency Manifesting as Severe Vasculopathy and Fatal Autoimmune Hemolytic Anemia.

    Ashari KA, Yaghmaie B, Pak N, Shahrooei M, Ziaee V, Parvaneh N. · 2026-05-29

    open access unreviewed
  8. 8
    Targeting Host Metabolic and Epigenetic Rewiring Blocks Lytic Gammaherpesvirus Production.

    Jones MC, Le TM, Mahoney CJ, Hartman SK, Dona RD, Gaspar YA, Hong SJ, Sheirbon BR, Escobar TM, Delgado T. · 2026-05-19

    open access unreviewed
  9. 9
    Molecular Surveillance of <i>Plasmodium vivax</i> and <i>Plasmodium falciparum</i> Drug Resistance Genes in the Republic of Korea: 2022-2025.

    Jung H, Shin HI, Ku B, Park E, Lee MR, Ju JW, Lee HI. · 2026-05-08

    open access unreviewed
  10. 10
    Sustained Effector Functions and Memory Accumulation of αβ T Cells in Children With Congenital Heart Disease.

    Abu YE, Kammeyer C, Yang T, Jauregui RG, Cramer A, Junge C, Kleiner S, Janssen A, Jirmo AC, Horke A, Förster … · 2026-05-01

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.