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rate-limiting unreviewed

CTP synthetase

1 reactions · 1 pathways

Cofactors used

ATP H2O Pi UTP

What it does, reaction by reaction

1 reactions

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)

step 9 Irreversible/directional

UTP → CTP

Converts UTP into CTP

› Notes

CTP synthetase catalyzes UTP + glutamine + ATP + H2O → CTP + glutamate + ADP + Pi. ATP activates UTP, and ammonia produced by the glutaminase domain is transferred to the synthase domain; this is the committed and regulatory step of CTP formation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP)

Accelerated by

UTP and glutamine availability; polymerization into cytoophidia can modulate activity

Inhibited by

CTP (feedback inhibition); glutamine limitation

Hormonal control

Expression increases in proliferating cells; no canonical acute endocrine regulator.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Enhanced lactose utilization from milk enriched in Uridine-5'-monophosphate drives hepatic energy storage in young mammals.

    Gao LM, Liu L, Yang XD, Long CM, Wu X. · 2026-06-01

    open access unreviewed
  2. 2
    Reprogramming energy system for growth and bioproduction from CO₂ and methanol in Escherichia coli.

    Liu K, Gao C, Liang G, Hu G, Song W, Wei W, Li X, Liu J, Chen H, Nielsen J, Liu L. · 2026-09-26

    open access unreviewed
  3. 3
    Modulation of DNA Damage by Epstein-Barr Virus (EBV).

    DiMaulo-Milk E, Damania B. · 2026-09-18

    open access unreviewed
  4. 4
    Exploratory Transcriptomic, Genomic, Pharmacogenomic, and Cellular Evaluation of FKBP4 in Lung Adenocarcinoma.

    Wang F, Lyu P, Chen W, Gu H, Han W, Yu Y, Chen C, He R, Liu Q. · 2026-09-19

    open access unreviewed
  5. 5
    A bacterial pangenome association study identifies a role for polyamine metabolism and alkaline tolerance in middle ear infections.

    Hammond JA, Ehrlich RL, Gonzalez A, Euba B, Raible KM, Lawrence JM, Gordon AB, Williams E, Marino MC, Limbo J… · 2026-09-25

    open access unreviewed
  6. 6
    Spectrum of Primary Hemophagocytic Lymphohistiocytosis-Associated Gene Mutations in Chinese Patients.

    Zheng W, Wang S, Du Z, Liao L, Li X, Ning H. · 2026-09-02

    open access unreviewed
  7. 7
    Prognostic impact of germline and somatic variants in lymphoma-associated haemophagocytic lymphohistiocytosis.

    Yang CF, Yeh YC, Hsu CY. · 2026-07-07

    unreviewed
  8. 8
    Selective Redox Tuning Enables Potent Intracellular Reduction of Nicotinamide Cytosine Dinucleotide.

    Guo X, Huang Y, Hu Y, Zhang L, Zhao ZK. · 2026-08-29

    open access unreviewed
  9. 9
    Loss of the mitochondrial SAM transporter reveals a lipoylation-dependent metabolic vulnerability in the postnatal heart.

    Rumyantseva A, Tippetts TS, Wilhalm A, Carter W, Moedas M, Rosenberger FA, Moore D, Végvári Á, Hinze Y, Muell… · 2026-08-26

    cited 1× open access unreviewed
  10. 10
    Unraveling the role of glutamine metabolism in cancer: from cell death mechanisms to tumor microenvironment modulation.

    Peng X, Liu S, Tao Y. · 2026-08-25

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.