rate-limiting unreviewed

CTP synthetase

1 reactions · 1 pathways

Cofactors used

ATP H2O Pi UTP

What it does, reaction by reaction

1 reactions

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)

step 9 Irreversible/directional

UTP → CTP

Converts UTP into CTP

› Notes

CTP synthetase catalyzes UTP + glutamine + ATP + H2O → CTP + glutamate + ADP + Pi. ATP activates UTP, and ammonia produced by the glutaminase domain is transferred to the synthase domain; this is the committed and regulatory step of CTP formation.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP)

Accelerated by

UTP and glutamine availability; polymerization into cytoophidia can modulate activity

Inhibited by

CTP (feedback inhibition); glutamine limitation

Hormonal control

Expression increases in proliferating cells; no canonical acute endocrine regulator.

Recent literature

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