CPS-II domain of carbamoyl-phosphate synthetase II (CPS-II)
Cofactors used
What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
Glutamine + bicarbonate → carbamoyl phosphate
Converts Glutamine HCO3- into Carbamoyl phosphate
› Notes
The CPS-II domain of carbamoyl-phosphate synthetase II (CPS-II) catalyzes glutamine + HCO3− + 2 ATP + H2O → carbamoyl phosphate + glutamate + 2 ADP + Pi. One ATP activates bicarbonate and a second phosphorylates carbamate; ammonia generated in the glutaminase domain is channeled internally. This cytosolic reaction is the committed, rate-limiting, and effectively irreversible step of mammalian pyrimidine de novo synthesis; it must not be confused with mitochondrial CPS-I of the urea cycle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Benefit of Linked-Color Imaging in Artificial Intelligence-Assisted Diagnosis of Early Gastric Cancer: A Pilot Study With Propensity Score Adjustment.
Mohamed AN, Minoda Y, Maruoka R, Suzuki Y, Fukuya H, Tsuru H, Wada M, Tanaka Y, Chinen T, Moriyama T, Ogino H… · 2026-07-28
unreviewed -
2
An accessible and open-source workflow for fabrication of custom PDMS culture chambers using 3D printing.
Algarín A, Cabrera PL, Scagliusi SF, Daza P, Yúfera A, Martín D. · 2026-08-06
unreviewed -
3
Analysis of deep learning techniques in computer-aided diagnosis for meniscus injuries: a systematic literature review.
Memon V, Syed Aluwee SAZB, Kumar YJ, Perhakaran VK. · 2026-08-14
unreviewed -
4
Agreement and workflow efficiency of AI-based coronary artery calcification quantification in lung cancer screening: Comparison with semi-automated and visual assessment.
Ochs K, Ensle F, Happe J, Jungblut L, Frauenfelder T, Kroschke J. · 2026-07-18
unreviewed -
5
Coronary artery calcium scoring using virtual vs. true non-contrast images from ultra-high-resolution and normal-resolution photon-counting coronary CT angiography.
Engel S, Shahzadi I, Haag NP, Gertz RJ, Niehoff JH, Surov A, Borggrefe J, Kroeger JR. · 2026-07-04
unreviewed -
6
Analyzing the impact of ionizable lipid identity, purity, and stability on lipid nanoparticle performance.
Rubio-Prego I, Beck-Broichsitter M, Samaridou E, Alonso MJ, Simon J. · 2026-06-27
unreviewed -
7
Co-occurring diabetes and depression and their impact on CVD, CAD, and stroke risk over a 10-year follow-up: A cohort study.
Ghazaee H, Mahdavizadeh V, Rezaee A, Darroudi S, Rezaee M, Esmaily H, Mehrabzadeh M, Shahabi HE, Sajadiyeh HS… · 2026-06-19
unreviewed -
8
Endometriosis and cardiovascular disease risk: a meta-analysis of cohort studies.
Wang L, Lu Y, Pan H, Li X, Luo L. · 2026-06-19
open access unreviewed -
9
Elevated atherogenic index of plasma is associated with severe acute kidney injury in critically ill patients with cardiovascular disease - a MIMIC-IV analysis with external validation in the eICU-CRD database.
Liu P, Shen Q, Liu Y, Hong K. · 2026-06-18
open access unreviewed -
10
High-throughput signal detection of hepatotoxic drug-drug interactions in hospitalized elderly patients: an NLP-driven pharmacovigilance study.
Ma J, Chen H, Guo C, He G, Yang G. · 2026-06-17
open access unreviewed
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