CPS-II domain of carbamoyl-phosphate synthetase II (CPS-II)
Cofactors used
What it does, reaction by reaction
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
Glutamine + bicarbonate → carbamoyl phosphate
Converts Glutamine HCO3- into Carbamoyl phosphate
› Notes
The CPS-II domain of carbamoyl-phosphate synthetase II (CPS-II) catalyzes glutamine + HCO3− + 2 ATP + H2O → carbamoyl phosphate + glutamate + 2 ADP + Pi. One ATP activates bicarbonate and a second phosphorylates carbamate; ammonia generated in the glutaminase domain is channeled internally. This cytosolic reaction is the committed, rate-limiting, and effectively irreversible step of mammalian pyrimidine de novo synthesis; it must not be confused with mitochondrial CPS-I of the urea cycle.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Benefit of Linked-Color Imaging in Artificial Intelligence-Assisted Diagnosis of Early Gastric Cancer: A Pilot Study With Propensity Score Adjustment.
Mohamed AN, Minoda Y, Maruoka R, Suzuki Y, Fukuya H, Tsuru H, Wada M, Tanaka Y, Chinen T, Moriyama T, Ogino H… · 2026-07-28
open access unreviewed -
2
A self-crosslinkable, adhesive intestine-derived extracellular matrix hydrogel enhances organoid retention and restores intestinal barrier integrity.
Kim YS, Han SY, An S, Lee MJ, Oh TG, Kim HJ, Son MY, Cho SW. · 2026-09-15
open access unreviewed -
3
Transient culture of adult human hepatocytes as organoids improves engineered liver engraftment.
Saxton SH, Kang I, Mitchell S, Lotto J, Upadhyay A, Zou C, Quirk C, McCray TN, Prado O, Johansson F, Fortin C… · 2026-07-23
open access unreviewed -
4
<i>Lactiplantibacillus plantarum</i> as a multifunctional probiotic for inflammatory bowel disease: Mechanisms, synbiotic strategies, and delivery systems.
Tao W, Liu W, Shi X, Han S, Shen Y, Sun W, Sha Y, Wang G, Chen Y, Ying H. · 2026-07-10
open access unreviewed -
5
Programmable 4D printing of sustainable multifunctional photoresins with tissue-matched mechanics for interfacial tissue regeneration.
Ghosal K, Wu Q, Ghosh A, Majumder R, Mandal M, Farah S. · 2026-09-12
open access unreviewed -
6
'<i>In Every River, in Every Lake</i>': Impacts of Beaver Population Change on Indigenous Livelihoods and Wellbeing in the Inuvialuit Settlement Region, Western Canadian Arctic.
Pearce C, Rohse M, Walshe N, Wheeler HC. · 2026-09-03
open access unreviewed -
7
A novel causative LMNA variant in acrogeria syndrome and literature review of genotype-phenotype correlations.
Huang H, Miao Y, Wang Y, Lei R, Zhang M, Zhang C, Cao X, Li M, Ren Y. · 2026-06-09
open access unreviewed -
8
Multi-granularity cross-image semantic modeling for medical ultrasound image segmentation.
Lu X, Yuan W, Gong X, Ma C. · 2026-07-21
unreviewed -
9
Altered Acylcarnitine Metabolism in cardiac diseases: From molecular mechanisms to translational potential.
Wu J, Zhang Y, Liu J, Zhao W, Liu X, Dan J. · 2026-09-25
open access unreviewed -
10
A prospective study of plasma levels of asprosin and incident type 2 diabetes in postmenopausal women.
Yang B, Li J, Ng S, Silva ES, Manson JE, Phillips LS, Reiner AP, Chopra AR, Liu S. · 2026-06-13
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.