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unreviewed

Biliverdin reductase (BLVRA)

1 reactions · 1 pathways

Cofactors used

NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut

step 2 Irreversible/directional

Biliverdin IXα + NADPH + H⁺ → bilirubin IXα + NADP⁺

Converts Biliverdin IX-alpha NADPH H+ into Bilirubin IX-alpha NADP+

› Notes

Cytosolic biliverdin reductase reduces the central methine bridge to form unconjugated bilirubin. NADPH is required; bilirubin is hydrophobic and is released into plasma bound tightly but noncovalently to albumin.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Degradation (Bilirubin Pathway)

Listed there as: Biliverdin reductase

Accelerated by

Biliverdin and NADPH availability

Inhibited by

NADPH deficiency/product accumulation

Hormonal control

No major direct hormonal control

Recent literature

Refresh

Europe PMC · from cache · sorted by publication date

  1. 1
    Integrated transcriptomics and metagenomics analyze the dynamic correlations between cecal mucosal tissue and cecal microbiota in Liangshan Yanying chickens during early postnatal development.

    Huang Z, Wang J, Yang C, Lv Z, Wang R. · 2026-04-09

    open access unreviewed
  2. 2
    Combined targeting of iron overload and BLVRA synergistically attenuates reactive astrocytes after subarachnoid hemorrhage.

    Zheng Y, Lang D, Li Z, Zhang J, Niu M, Li W, Huang L, Xue J, Li L, Chen Y. · 2026-04-22

    unreviewed
  3. 3
    The red blood cell proteome and interactome identify a Band 3-BLVRB axis regulating hypoxic metabolic adaptation.

    Issaian AV, Dzieciatkowska M, Bevers S, Safari Z, Hay AM, Cendali FI, Argabright A, Rogers SC, Saviola AJ, Re… · 2026-06-01

    unreviewed
  4. 4
    Hypomorphic biliverdin reductase a mutations define bilirubin anti-malarial threshold.

    Mesquita M, Figueiredo A, Rastogi ST, Martins R, Ramos S, Pagnotta S, Carlos AR, Costa M, Cardoso S, Novoa A,… · 2026-04-30

    open access unreviewed
  5. 5
    Mechanisms of Red-Shifted Absorption in Biliverdin-Binding Proteins.

    Noji T, Saito K, Ishikita H. · 2026-05-19

    unreviewed
  6. 6
    Red blood cell membrane proteome as a reporter of disease severity, transfusion impact and genetic background in transfusion-dependent β-thalassaemia.

    Theocharaki K, Delicou S, Ntzoura-Kani A, Simantiris N, Politou M, Komninaka V, Samiotaki M, Zoidakis J, Anto… · 2026-04-09

    open access unreviewed
  7. 7
    Bilirubin reductase regulates macrophage senescence and modulates implant-associated Staphylococcus aureus osteomyelitis.

    Zhang J, Mao X, Zheng H, Yang K, Yu B. · 2026-05-14

    unreviewed
  8. 8
    SPIC-dependent erythrophagocytic macrophages drive granuloma formation and pathogen persistence during intracellular bacterial infection

    · 2026-05-27

    open access unreviewed
  9. 9
    The Human Lens Fiber Cytoskeletome Reveals Neuronal Signatures and the Presence of Chaperonins, Proteasome, Signaling, and Redox Regulators.

    Maddala R, Lankford LK, Skiba NP, Rao PV. · 2026-05-01

    open access unreviewed
  10. 10
    Bilirubin as a Modulator of WNK1 Protein Signaling: Implications for Neuroinflammatory Diseases.

    Jayanti S, Vítek L, Gazzin S, Tiribelli C. · 2026-03-20

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.