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unreviewed

Biliverdin reductase (BLVRA)

1 reactions · 1 pathways

Cofactors used

NADP+ · B3 (Niacin) NADPH · B3 (Niacin)

What it does, reaction by reaction

1 reactions

Heme Degradation (Bilirubin Pathway) Amino Acid & Nitrogen Metabolism · Reticuloendothelial system, liver ER, gut

step 2 Irreversible/directional

Biliverdin IXα + NADPH + H⁺ → bilirubin IXα + NADP⁺

Converts Biliverdin IX-alpha NADPH H+ into Bilirubin IX-alpha NADP+

› Notes

Cytosolic biliverdin reductase reduces the central methine bridge to form unconjugated bilirubin. NADPH is required; bilirubin is hydrophobic and is released into plasma bound tightly but noncovalently to albumin.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

1 entries

Heme Degradation (Bilirubin Pathway)

Listed there as: Biliverdin reductase

Accelerated by

Biliverdin and NADPH availability

Inhibited by

NADPH deficiency/product accumulation

Hormonal control

No major direct hormonal control

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    The mediating role of genes in the influence of intestinal flora on type 2 diabetes and the screening of diagnostic markers.

    Chen YY, Shi YF, Zhang XY, Zhang JY, Zhang SM, Zhao HX, Liu DL. · 2026-07-23

    open access unreviewed
  2. 2
    Mesenchymal stem cell-derived extracellular vesicle treatment of induced pluripotent stem cell-derived motor neurons with different amyotrophic lateral sclerosis genetic backgrounds.

    Varderidou-Minasian S, Jakobs CE, Pasteuning-Vuhman S, Gal L, Timmers A, Altelaar M, Lorenowicz MJ, Pasterkam… · 2026-02-05

    open access unreviewed
  3. 3
    Maternal Immune Activation Leads to Lasting Sex-Specific Changes in Behavior and Hippocampal Morphological and Molecular Features in 12-Month-Old Rat Offspring.

    Sentyabreva AV, Lyamtsev AS, Melnikova EA, Aliper GM, Kosyreva AM. · 2026-09-15

    open access unreviewed
  4. 4
    Serpin-driven green camouflage and NIR fluorescence in frogs.

    Vignesh R, Vu T, Harvey G, Menozzi L, Delia J, White W, Lin P, Galatis E, Johnsen S, Yao J, Taboada C. · 2026-09-16

    open access unreviewed
  5. 5
    <i>Caenorhabditis elegans</i> as a Model for Studying Nrf2/SKN-1 Activation in Alzheimer's Disease: Plant Bioactive Compounds and Therapeutic Translation.

    Bellver-Sanchis A, Ralchev NR, Romanska PR, Dyakova NK, Ivanova KI, Griñán-Ferré C, Marchev AS. · 2026-09-01

    open access unreviewed
  6. 6
    The red blood cell proteome and interactome identify a Band 3-BLVRB axis regulating hypoxic metabolic adaptation.

    Issaian AV, Dzieciatkowska M, Bevers S, Safari Z, Hay A, Cendali FI, Argabright A, Rogers SC, Saviola A, Redz… · 2026-09-01

    unreviewed
  7. 7
    A Structure-guided Active Site Affinity Ligand Unmasks a Stress-Sensitizing Role for BLVRB in the Endoplasmic Reticulum.

    Thekke Veedu RR, Sheriff J, Nesbitt NM, Marchenko N, Pennacchia L, Ginex T, Hearing P, Kreitler DF, Bahou WF. · 2026-08-01

    open access unreviewed
  8. 8
    Integrated transcriptomics and metagenomics analyze the dynamic correlations between cecal mucosal tissue and cecal microbiota in Liangshan Yanying chickens during early postnatal development.

    Huang Z, Wang J, Yang C, Lv Z, Wang R. · 2026-04-09

    open access unreviewed
  9. 9
    Combined targeting of iron overload and BLVRA synergistically attenuates reactive astrocytes after subarachnoid hemorrhage.

    Zheng Y, Lang D, Li Z, Zhang J, Niu M, Li W, Huang L, Xue J, Li L, Chen Y. · 2026-04-22

    unreviewed
  10. 10
    Educational Case: Glucose-6-phosphate dehydrogenase (G6PD) deficiency anemia.

    Bussing K, Brehl N, Inman A, Davidson D. · 2026-07-24

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.