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unreviewed

Vitamin D 25-hydroxylase (CYP2R1/CYP27A1)

1 reactions · 1 pathways

Cofactors used

NADPH · B3 (Niacin) O2

What it does, reaction by reaction

1 reactions

Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria

step 2 Irreversible/directional

Cholecalciferol -> 25-hydroxycholecalciferol (calcidiol)

Converts Cholecalciferol (vitamin D3) into 25-Hydroxycholecalciferol

› Notes

Hepatic and essentially unregulated, so serum 25-OH-D is the storage form and the assay used to assess vitamin D status.

Showing all 1 reactions.

What accelerates and inhibits it

Regulation is pathway-specific, so each context is listed separately

0 entries

No regulation recorded for this enzyme in the source documents.

Recent literature

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Europe PMC · fetched just now · sorted by publication date

  1. 1
    Alfacalcidol plus calcium versus cholecalciferol in glucocorticoid-exposed children with nephrotic syndrome: a randomized controlled trial.

    Chen HR, Tang H, Zhang M, Lin JA, Lin XQ, Zhang JY, Lu JY, Xia HM, Gao X, Liao X. · 2026-03-03

    cited 1× open access unreviewed
  2. 2
    The Role of Vitamin D3 in Periodontal Health: Implications for Bone Metabolism, Immune Modulation and Inflammation Control

    Moszura J, Gawlak-Socka S, Pęksa J, Bielecka-Kowalska N, Kłosek S. · 2026-02-01

    open access unreviewed
  3. 3
    Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.

    Varzideh F, Mone P, Kansakar U, Santulli G. · 2026-02-02

    cited 2× open access unreviewed
  4. 4
    Prognostic impact of circulating vitamin D and genetic variants in the vitamin D pathway in glioblastoma.

    Morelli M, Di Lorenzo F, Marchetto F, Menicagli M, Franceschi S, Giacomarra M, Gambacciani C, Pieri F, Pasqua… · 2026-01-01

    open access unreviewed
  5. 5
    Importance of vitamin D in gastrointestinal health and disease.

    Sonsalla SG, Armbruster-Lee J, Samarasinghe AE. · 2026-05-18

    open access unreviewed
  6. 6
    Exploring Vitamin D Signaling-Associated Biomarkers and Their Diagnostic Value in Diabetic Retinopathy: A Combined Transcriptomic and Single-Cell Analysis With Experimental Validation.

    Chen P, Li R, Zhao K, Liu R, Hao Y. · 2026-01-01

    open access unreviewed
  7. 7
    Long-term Western diet feeding impairs hepatic vitamin D metabolism and promotes bone loss in mice.

    Zhou P, Hammour MM, Aspera-Werz RH, Ehnert S, Myllys M, Hobloss Z, Hassan R, Gonzalez D, Hendawi R, Edlund K,… · 2026-01-23

    open access unreviewed
  8. 8
    Disrupted Vitamin D Metabolism in Hepatocellular Carcinoma: Free and Bioavailable 25(OH)D as Novel Biomarkers of Hepatic Reserve and Clinical Risk.

    Osredkar J, Rakusa M, Jerin A, Štabuc B, Zaplotnik M, Štupar S, Siuka D. · 2026-01-13

    open access unreviewed
  9. 9
    Pre-exposure of zebrafish (Danio rerio) larvae to high doses of vitamin D<sub>3</sub> enhances toxicity to bacterial lipopolysaccharide.

    Leuschner SE, Shandilya UK, Huyben D, Bridle BW, Van Raay TJ, Karrow NA. · 2025-10-09

    unreviewed
  10. 10
    Manganese Deficiency and Mn<sub>2</sub>O<sub>3</sub> Nanoparticles Supplementation Disrupt Bone Remodeling and Mineral Matrix Maturation in Rats.

    Cholewińska E, Juśkiewicz J, Fotschki B, Ognik K. · 2025-12-23

    open access unreviewed

External claims. These come from an index outside this database and are not checked against it. Treat them as leads.