Vitamin D 25-hydroxylase (CYP2R1/CYP27A1)
Cofactors used
What it does, reaction by reaction
Vitamin D Activation Cofactor & Vitamin Metabolism · Skin, liver ER, renal proximal tubule mitochondria
Cholecalciferol -> 25-hydroxycholecalciferol (calcidiol)
Converts Cholecalciferol (vitamin D3) into 25-Hydroxycholecalciferol
› Notes
Hepatic and essentially unregulated, so serum 25-OH-D is the storage form and the assay used to assess vitamin D status.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Free Fatty acid-induced disruption of hepatic vitamin D metabolism impairs bone homeostasis in an in vitro 3D human liver-bone model.
Hammour MM, Herzberger L, Xin Y, Chen G, Tombaz M, Ehnert S, Springer F, Damm G, Vosough M, Hengstler JG, Mül… · 2026-05-13
open access unreviewed -
2
Association between vitamin D deficiency and clinical outcomes in critically ill patients: A retrospective cohort study.
Chen Y, Deng W, Deng Y, Zheng D, Dang L, Wang J, Wu W, Huang G. · 2026-08-27
open access unreviewed -
3
From the Vitamin D Paradox to Precision Nutrition: Targeted Supplementation, Assay Pitfalls, and Clinical Decision-Making.
Dalamaga M, Tsilingiris D, Petropoulou D, Emfietzoglou R, Kypraiou M, Kounatidis DC, Vallianou NG, Karras S, … · 2026-07-03
cited 1× open access unreviewed -
4
Alfacalcidol plus calcium versus cholecalciferol in glucocorticoid-exposed children with nephrotic syndrome: a randomized controlled trial.
Chen HR, Tang H, Zhang M, Lin JA, Lin XQ, Zhang JY, Lu JY, Xia HM, Gao X, Liao X. · 2026-03-03
cited 1× open access unreviewed -
5
The Role of Vitamin D<sub>3</sub> in Periodontal Health: Implications for Bone Metabolism, Immune Modulation and Inflammation Control.
Moszura J, Gawlak-Socka S, Pęksa J, Bielecka-Kowalska N, Kłosek S. · 2026-02-10
cited 1× open access unreviewed -
6
Vitamin D in Cardiovascular Medicine: From Molecular Mechanisms to Clinical Translation.
Varzideh F, Mone P, Kansakar U, Santulli G. · 2026-02-02
cited 11× open access unreviewed -
7
SARS-CoV-2 infection induces functional impairment of vitamin D receptor signaling to drive interleukin 6-dependent hyperinflammation in mononuclear phagocytes.
Valdés-López JF, di Filippo D, Penagos S, Hernández-Sarmiento LJ, Arroyave-Ospina JC, Rojas M, Urcuqui-Inchim… · 2026-09-11
open access unreviewed -
8
Beyond VDR: Vitamin D Metabolism Genes in Tuberculosis Susceptibility, Immune Response and Implications for Diabetes Mellitus.
Rabadi M, Hussain Z, Siddiqui SF, Siddiqui HF, Nomikos M, Seed Ahmed M. · 2026-08-10
open access unreviewed -
9
Serum 25(OH)D3 and advanced liver fibrosis in type 2 diabetes: a Chinese hospital cohort with NHANES validation and mortality follow-up.
Zhao G, Yang J, Zhang L, Yang S, Niu D, Yang M, Gao Z, Ma F, Gao B. · 2026-07-22
open access unreviewed -
10
Prognostic impact of circulating vitamin D and genetic variants in the vitamin D pathway in glioblastoma.
Morelli M, Di Lorenzo F, Marchetto F, Menicagli M, Franceschi S, Giacomarra M, Gambacciani C, Pieri F, Pasqua… · 2026-01-01
cited 1× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.