Thioredoxin reductase (TXNRD)
Cofactors used
What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
Oxidized thioredoxin → reduced thioredoxin
Converts Oxidized thioredoxin into Reduced thioredoxin
› Notes
Thioredoxin reductase catalyzes oxidized thioredoxin + NADPH + H+ → reduced thioredoxin + NADP+. This FAD- and selenocysteine-containing flavoprotein restores the RNR electron donor after each catalytic cycle. The glutaredoxin alternative is sustained by glutathione reductase, which uses NADPH to regenerate reduced glutathione.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Diet plays a supportive role in managing thyroid disorders - but a critical one!
Persani L, Duntas LH. · 2026-06-17
open access unreviewed -
2
Proteomic Analysis of the Metabolic Response of UVA-Exposed Melanocytes Following Co-Treatment with Cannabigerol and 3-<i>O</i>-Ethylascorbic Acid.
Mucha M, Ryšavá A, Jarocka-Karpowicz I, Maruška A, Skrzydlewska E, Gęgotek A. · 2026-05-23
open access unreviewed -
3
Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.
Brenner M, Höhlein S, Wirth P, Neidt L, Lappe M, Hopke E, Sfakianaki E, Fischer M, Hadamek K, Keller A, Bothe… · 2026-05-29
open access unreviewed -
4
Cell surface thiol-disulfide regulation in cancer: Mechanisms, implications, and theranostic strategies.
Lühle J, Seeberger PH, Moscovitz O. · 2026-03-25
cited 1× open access unreviewed -
5
Inverse Correlation Between Nesfatin-1 and Ghrelin O-Acyltransferase (GOAT) in Adolescents with Epilepsy: A Cross-Sectional Study.
Sojka A, Yetkin O, Bartosik Y, Steinborn B, Dorocka-Bobkowska B, Zarowski M. · 2026-04-28
open access unreviewed -
6
Isoalantolactone induces AML pyroptosis and potentiates <i>α</i>-PD-1 efficacy by targeting selenoprotein TXNRD1.
Yu X, Zhou Y, Sun S, Tang L, Zhang W, Xu J, Liu W. · 2025-12-29
cited 1× open access unreviewed -
7
A pan-cancer analysis of TMEM132A in human tumors.
Chu T, Lei C, Zhang X, Wang Y, Gao M. · 2026-04-26
open access unreviewed -
8
Selenium and Selenoproteins in Neutrophil Functions.
Lee TJ, Prabhu KS. · 2025-09-18
cited 1× open access unreviewed -
9
Selenium-Biofortified Probiotics: A Synergistic Microbial-Nutritional Strategy Against Exercise-Induced Stress.
Wang Q, Xing J, Huang Y, Huang J, Zhu K, Zhang X. · 2026-03-18
cited 1× open access unreviewed -
10
Tracing the vertebrate selenoproteome evolution reveals expansions in ray-finned fishes and convergent depletions in tetrapods.
Ticó M, Lozano-Fernandez J, Mariotti M. · 2026-03-24
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.