Thioredoxin reductase (TXNRD)
Cofactors used
What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
Oxidized thioredoxin → reduced thioredoxin
Converts Oxidized thioredoxin into Reduced thioredoxin
› Notes
Thioredoxin reductase catalyzes oxidized thioredoxin + NADPH + H+ → reduced thioredoxin + NADP+. This FAD- and selenocysteine-containing flavoprotein restores the RNR electron donor after each catalytic cycle. The glutaredoxin alternative is sustained by glutathione reductase, which uses NADPH to regenerate reduced glutathione.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Pharmacological Potential of Selenoproteins in the Regulation of Oxidative Stress in Liver Diseases.
Varlamova EG. · 2026-09-16
open access unreviewed -
2
PCK2 Inhibition Reverses Cisplatin Resistance of Non-Small Cell Lung Cancer by Triggering Ferroptosis.
Liu J, Wang Z, Gu C, Chen Y, Yang Y, Zhu J, Zhang Y, Shao Y, Pang X, Ge Y, Qian H, Huang JA, Liu Z, Zeng Y, J… · 2026-08-01
open access unreviewed -
3
Redox Homeostasis, Metabolic Pathways and Plasticity in Uveal Melanoma Compared to Other Cancers.
Păsărică MA, Curcă PF, Dragosloveanu CDM, Nisipașu CI, Curcă GC. · 2026-07-25
open access unreviewed -
4
Effects of cold water immersion versus active recovery on oxidative stress, redox gene expression and mitochondrial adaptations after strength training.
Roberts LA, Pileggi CA, Zeng N, Figueiredo VC, Markworth JF, Raastad T, Briskey D, Suzuki K, Coombes JS, Came… · 2026-07-22
cited 1× open access unreviewed -
5
A comprehensive proteome and the first phosphoproteome reveal extensive phosphorylation of carbohydrate metabolism in Cryptosporidium parvum sporozoites.
Wang D, Li M, Wang C, Li H, Yin J, Zhu G. · 2026-07-02
cited 1× open access unreviewed -
6
Metal-dependent regulated cell death: Molecular architecture and translational frontiers.
Hu H, Chen Z, Li Y, Peng J, Cao J, Zhou H, Wang M, Du Y, Wu H, Zhao H, Huang S, Yu D, Liu M, Shevchenko OV, M… · 2026-06-01
open access unreviewed -
7
Diet plays a supportive role in managing thyroid disorders - but a critical one!
Persani L, Duntas LH. · 2026-06-17
open access unreviewed -
8
Proteomic Analysis of the Metabolic Response of UVA-Exposed Melanocytes Following Co-Treatment with Cannabigerol and 3-<i>O</i>-Ethylascorbic Acid.
Mucha M, Ryšavá A, Jarocka-Karpowicz I, Maruška A, Skrzydlewska E, Gęgotek A. · 2026-05-23
open access unreviewed -
9
A dual-pronged strategy: multi-bioactive nanoplatform synergizes ROS antidote and iron stabilization to protect against liver ischemia-reperfusion injury.
Dong J, Zhu P, Gao C, Wang Q, Zhang J, Han Y, Feng R, Chen T, Sun J, Zhang R. · 2026-05-29
open access unreviewed -
10
Metabolic rewiring driven by phosphoglycolate phosphatase deletion inhibits ferroptosis.
Brenner M, Höhlein S, Wirth P, Neidt L, Lappe M, Hopke E, Sfakianaki E, Fischer M, Hadamek K, Keller A, Bothe… · 2026-05-29
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.