Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1)
Clinical / pharmacological. SCOT deficiency: ketoacidosis; absent in liver, which is why liver cannot use ketones
What it does, reaction by reaction
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
Converts Acetoacetate Succinyl-CoA into Acetoacetyl-CoA Succinate
› Notes
Succinyl-CoA:3-ketoacid CoA transferase (SCOT; 3-oxoacid CoA-transferase, OXCT1) activates acetoacetate by transferring CoA from succinyl-CoA. This is the committed, functionally rate-determining step of ketone-body utilization; it bypasses succinyl-CoA synthetase and therefore sacrifices the GTP that would otherwise be generated in the TCA cycle. Liver lacks SCOT, preventing futile cycling.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Branched-chain amino acids and gut microbiota: coregulation and impact on neurological function via the gut-brain axis.
Li Q, Fan B, Xiao Y, Zhang Z, Zhao S, Liao B, Zeng J, Shan X, Ye H, Wen Y, Zhang L, Guo H, Xiao F, Zhu H. · 2026-07-14
open access unreviewed -
2
Ketogenic diet attenuates Müller cell activation and retinal neuroinflammation in autoimmune glaucoma through acetylation‑mediated FOXO signalling.
Tan S, Wang X, Zheng Y, Mou Z, Zeng L, Yuan J, Fan X, Wei M, Huo Y, Ouyang R, Pu Y, Lei J, Gao X, Wang D, Pen… · 2026-09-18
open access unreviewed -
3
Research progress in metabolic reprogramming and targeting metabolic pathways for clear cell renal cell carcinoma.
Yao JT, Hu PC, Li XW, Xu JC, Wang KJ, Ye SZ, Meng XY, Chen HC, Liang Y, Ma Q. · 2025-12-19
open access unreviewed -
4
CCNE1: A Cell Cycle Regulator That Influences Tumor Progression.
Yan L, Liu S, Li Y, He Q, Long C, Tang N, Zhou Y. · 2026-10-01
open access unreviewed -
5
Murine metabolic HFpEF is associated with altered mitochondrial substrate handling and S-nitrosylation remodeling.
Li H, Cui H, Wang D, Leuschner F, Heineke J, Hu J, Bibli SI. · 2026-08-12
open access unreviewed -
6
Mitochondria-to-plasma-membrane H<sub>2</sub>O<sub>2</sub> signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells.
Klöppel E, Engstová H, Duspiva P, Tauber J, Mozheitova O, Jabůrek M, Ježek P. · 2026-07-16
open access unreviewed -
7
Nuclear OXCT1 attenuates histone β-hydroxybutyrylation-mediated MHC-I transcription.
Hu Z, Lv W, Wen T, Sun J, Ji G, Ru S, Sun X, Wang Z, Ren H, Zhang Y, Chen P, Zhou L, Wu S, Jia X, Liu S, Zhu … · 2026-05-27
cited 3× unreviewed -
8
Neuropathology of Friedreich ataxia and its links to metabolic pathways.
Mercado-Ayón E, Lazaropoulos MP, Mercado-Ayón Y, Lynch DR. · 2025-12-25
cited 2× open access unreviewed -
9
Omics Studies in Osteoarthritis: A Review of Molecular Mechanisms and Candidate Molecules.
Sun Y, Xiao Q, Jin M, Liu G, Zhang Q, Wei X. · 2026-09-18
open access unreviewed -
10
Propionic Acidemia: An Ambispective Cohort Study on Phenotypic and Genotypic Characteristics at a Tertiary Center in Vietnam.
Quang DM, Vu CD, Nguyen KN, Nguyen NL, Mai TTC, Huong NTT, Mo DT, Phuong LT, Tran TH, Tu NH, Khoa NX, Vuong V… · 2026-09-11
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.