Succinyl-CoA:3-ketoacid CoA transferase (SCOT / OXCT1)
Clinical / pharmacological. SCOT deficiency: ketoacidosis; absent in liver, which is why liver cannot use ketones
What it does, reaction by reaction
Ketolysis (Ketone Body Utilization) Lipid Metabolism · Mitochondrial matrix
Acetoacetate + succinyl-CoA → acetoacetyl-CoA + succinate
Converts Acetoacetate Succinyl-CoA into Acetoacetyl-CoA Succinate
› Notes
Succinyl-CoA:3-ketoacid CoA transferase (SCOT; 3-oxoacid CoA-transferase, OXCT1) activates acetoacetate by transferring CoA from succinyl-CoA. This is the committed, functionally rate-determining step of ketone-body utilization; it bypasses succinyl-CoA synthetase and therefore sacrifices the GTP that would otherwise be generated in the TCA cycle. Liver lacks SCOT, preventing futile cycling.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
Impaired Lung BCAA Metabolism Promotes Ferroptosis and Resultant Pulmonary Arterial Hypertension-Associated Hepatopathy.
Blake MJ, Hong J, Brownstein A, Rhodes CJ, Swietlik EM, Blake JC, Moon RA, Hartweck LM, Mendelson JB, Prisco … · 2026-05-30
open access unreviewed -
2
Integration of whole genome resequencing and transcriptomics reveals key candidate genes and pathway for fatty acid and amino acid compositions among duck breeds.
Xie H, Hu X, Wang S, Liu H, He Z, Ji H, Lv K, Zhu T, Wang J. · 2026-05-02
open access unreviewed -
3
AI-Powered Deep Visual Proteomics Reveals Critical Molecular Transitions in Pancreatic Cancer Precursors.
Min J, Schweizer L, Zonderland G, Selvanesan BC, Thomsen JH, Oldenburg L, Bae SW, Kim B, Hernández SD, Jez G,… · 2026-07-01
open access unreviewed -
4
Decoding the Apical–Basal Surfaceome of Colon Epithelial Cells via Side-Selective Biotinylation
Kuffa K, Langó T, Czirók A, Tárnoki-Zách J, Bősze S, László L, Vas V, Szabó Z, Tusnády G. · 2026-06-01
open access unreviewed -
5
Integrated three-dimensional genomic analysis reveals that dynamic changes in chromatin structure are associated with differences in egg production performance between White Leghorn and Wenchang chickens.
Wang S, Cao Y, Tian GG. · 2026-06-10
open access unreviewed -
6
ScRNA-seq Data Reveal Gene Upregulation and Downregulation in Oxygen-Induced Retinopathy.
Wang X, Wang L, Ju Y. · 2026-06-11
open access unreviewed -
7
Correction: Integrated methylome-transcriptome profiling reveals epigenetic regulation of immune activation pathways and CSN3-associated lactation repression in bovine subclinical mastitis.
Dwivedi S, Kumar A, De UK, Chauhan A, Agrawal RK, Khanna S, Upadhyay A, Singh A, Devatwal PC, Dutt T. · 2026-06-09
open access unreviewed -
8
The significance of the ketolytic gene OXCT1 in metabolism, intracellular signaling and disease development.
Górecka K, Soboska K, Pacholczyk M, Pirola L, Balcerczyk A. · 2026-06-06
unreviewed -
9
CYP46A1 activation by low-dose efavirenz uncovers the link between brain cholesterol metabolism, energetics, and vasculature.
Mast N, Bederman I, El-Darzi N, Pikuleva IA. · 2026-04-30
open access unreviewed -
10
Ketone body metabolism activates the immune response against <i>Staphylococcus aureus</i> infection by fueling the tricarboxylic acid cycle and affecting histone β-hydroxybutyrylation.
Cai H, Yue X, Chen Y, Chen X, Qiao R, Zhong G, Rong S, Zhang L, Li Z, Liao A, Xiong W, Guo C, Zhu Y, Deng K, … · 2026-04-03
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.