Succinate dehydrogenase (Complex II)
Cofactors used
Clinical / pharmacological. SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Succinate + FAD ⇌ fumarate + FADH2 (enzyme-bound); ubiquinone is reduced to ubiquinol in the respiratory chain
Converts Succinate FAD into Fumarate FADH2 (enzyme-bound)
› Notes
Required cofactors: covalently bound FAD, iron-sulfur centers, and heme b; electrons pass from FADH2 through Fe–S centers to ubiquinone (CoQ). This reversible step does not pump protons and yields reducing equivalents at the CoQ pool rather than free NADH.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Common pathways and outliers in glucose catabolism across Trypanosomatidae.
Opperdoes FR, Alencar MB, Silber AM, Škodová-Sveráková I, Záhonová K, Yurchenko V. · 2026-08-05
unreviewed -
2
The Role of the Surgical Pathologist in the Recognition of Hereditary SDH-Deficient Tumor Syndromes.
Juhlin CC, Mete O. · 2026-06-12
unreviewed -
3
Hypertension Drives Protein Lactylation and Vascular Dysfunction in Skeletal Muscle.
Fontes MT, Townsend P, Butler L, Parente JM, Araujo FA, Costa TJ, Bomfim GF, Pernomian L, Tan W, VanderVeen B… · 2026-04-22
unreviewed -
4
Sex differences in brain glucose metabolism and Alzheimer's disease risk and progression.
Ramezan M, Demetriou A, Burke SN, Nalvarte I, Shin AC. · 2026-06-01
open access unreviewed -
5
Mitochondrial OXPHOS restricts SARS-CoV-2 replication.
Soto Albrecht YE, Morrow RM, Kenney D, Olali AZ, Wacquiez A, Chehadeh N, Cen Z, Haltom JA, Chen I, Ranshing S… · 2026-06-03
open access unreviewed -
6
Integrative Transcriptomic, Network, and Machine Learning Analyses Identify Genistein and Resveratrol-Associated Therapeutic Targets in Alzheimer's Disease.
Isıyel M, Ceylan H, Demir Y. · 2026-06-02
open access unreviewed -
7
Strategies and challenges in developing pre-vascularized three-dimensional skin substitutes using layer-by-layer cell coating technology.
Tsunoi Y, Miyazaki H. · 2026-04-23
open access unreviewed -
8
Free Radical Formation in the Reactions of Redox-Active Drugs and Xenobiotics with Mitochondrial Flavoenzymes
· 2026-05-29
open access unreviewed -
9
Urinary Biomarkers in Parkinson's Disease: A Structured Integrative Review of Pathophysiological Pathways.
Santos HQP, Sumita NM, Alberto-Silva C, Echeverry MB. · 2026-05-17
open access unreviewed -
10
Report of the scientific network Holimitox on succinate dehydrogenase inhibitor (SDHI) pesticides: new insights and challenges with an EcoHealth approach-presentations and round tables from the Holimitox day on November 7, 2024.
Bonmatin JM, Chamaraux F, Jean S, Abbey E, Bézard E, Bouly L, Buffin-Meyer B, Buleon M, Castellino T, Delbac … · 2026-05-27
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.