Succinate dehydrogenase (Complex II)
Cofactors used
Clinical / pharmacological. SDH mutations: paraganglioma, phaeochromocytoma, GIST; inhibited by malonate
What it does, reaction by reaction
Citric Acid Cycle (TCA / Krebs Cycle) Energy Metabolism & Cellular Respiration · Mitochondrial matrix
Succinate + FAD ⇌ fumarate + FADH2 (enzyme-bound); ubiquinone is reduced to ubiquinol in the respiratory chain
Converts Succinate FAD into Fumarate FADH2 (enzyme-bound)
› Notes
Required cofactors: covalently bound FAD, iron-sulfur centers, and heme b; electrons pass from FADH2 through Fe–S centers to ubiquinone (CoQ). This reversible step does not pump protons and yields reducing equivalents at the CoQ pool rather than free NADH.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Pancreatic Cancer Disrupts Circadian Patterns of Gene Expression in Cardiorespiratory Muscles.
Ducharme JB, Schonk MM, Gutierrez-Monreal MA, Ferreira LF, Esser KA, Judge AR, Judge SM. · 2026-10-01
open access unreviewed -
2
Amyloid-Forming Amylin Secreted by the Pancreas Promotes Hypoxia-Inducible Factor Activation and Mitochondrial Alterations in Liver and Heart During Type 2 Diabetes Pathogenesis.
Knapton AE, Verma N, Kotiya D, Sowton AP, Thackray BD, Holzner LMW, Darwin PM, Despa S, Despa F, Murray AJ. · 2026-09-04
open access unreviewed -
3
Understanding physiological adaptations of pregnancy to the chronic hypoxia of high altitude to inform obstetrical and neonatal care.
Arenas GA, Herrera EA, Krause BJ, Giussani DA, Julian CG, Moore LG, Lorca RA. · 2026-08-14
unreviewed -
4
Mitochondria-to-plasma-membrane H<sub>2</sub>O<sub>2</sub> signaling induced by branched-chain keto acid oxidation essentially stimulates insulin secretion in pancreatic β-cells.
Klöppel E, Engstová H, Duspiva P, Tauber J, Mozheitova O, Jabůrek M, Ježek P. · 2026-07-16
open access unreviewed -
5
Effects of copper overload on mitochondrial parameters in GBM-1, U-87 MG, and C6 glioma cell lines.
Tassinari G, de Souza LA, Aguiar de Souza N, Radowitz Mendonça Y, Stoeberl L, Silveira de Melo M, Nazari EM, … · 2026-07-25
open access unreviewed -
6
Integrated Metabolomic and Proteomic Analyses Reveal Differential Regulation of the Citrate Cycle and Pentose Phosphate Pathway by <i>Cannabis sativa</i> Extract and the Synthetic Cannabinoid HU210 in GT1-7 Neuronal Cells: Sequential Extraction of Metabolites and Proteins from a Single Cell Pellet.
Natori Y, Mizuno D, Doshi M, Kawahara M, Ishii A. · 2026-09-03
open access unreviewed -
7
Redox Regulation in Glioblastoma: Mechanisms, Biomarkers, and Therapeutic Implications.
Lamrabet S, Houssaini AS, Bennis S, Ameziane El Hassani R. · 2026-09-06
open access unreviewed -
8
Heat Shock Proteins in Cancer: Mechanisms and Therapeutic Targeting.
Ma S, Liu CQ, Ma SY, Wang SG, Xia QD, Xu MY. · 2026-09-11
open access unreviewed -
9
Androgen receptor imprints satellite cell stemness and preserves their reservoir for lifelong regeneration and optimal repair.
Rizk JG, Ghaibour KC, Souali-Crespo S, Calvano E, Bilger A, Jacobs H, Messaddeq N, Cai Q, Grangirard E, Sahu … · 2026-09-09
open access unreviewed -
10
The molecular mechanisms of crista formation: how mitochondria give themselves breathing room.
Colina-Tenorio L, Bohuslavová M, Bruce AW, Hashimi H. · 2026-09-01
open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.