What it does, reaction by reaction
Triacylglycerol Synthesis and Lipolysis Lipid Metabolism · Cytosol / ER
Phosphatidic acid + H2O → diacylglycerol (DAG) + Pi
Converts Phosphatidic acid H2O into Diacylglycerol (DAG) Pi
› Notes
Phosphatidic acid phosphatase (PAP; lipin) dephosphorylates phosphatidic acid. Lipin activity directs phosphatidic acid toward TAG synthesis rather than phospholipid signaling pathways.
Showing all 1 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · from cache · sorted by publication date
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1
A membrane-sensing mechanism links lipid metabolism to protein degradation at the nuclear envelope.
Lee S, Carrasquillo Rodrı Guez JW, Merta H, Bahmanyar S. · 2023-06-29
cited 36× open access unreviewed -
2
Interplay between Lipid Metabolism, Lipid Droplets, and DNA Virus Infections.
Farías MA, Diethelm-Varela B, Navarro AJ, Kalergis AM, González PA. · 2022-07-17
cited 44× open access unreviewed -
3
Coupling lipid synthesis with nuclear envelope remodeling.
Barger SR, Penfield L, Bahmanyar S. · 2021-09-20
cited 35× unreviewed -
4
Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy.
Song L, Liu Z, Hu HH, Yang Y, Li TY, Lin ZZ, Ye J, Chen J, Huang X, Liu DT, Zhou J, Shi Y, Zhao H, Xie C, Che… · 2020-11-17
cited 64× open access unreviewed -
5
Hypolipidemic effects of herbal extracts by reduction of adipocyte differentiation, intracellular neutral lipid content, lipolysis, fatty acid exchange and lipid droplet motility.
Haselgrübler R, Lanzerstorfer P, Röhrl C, Stübl F, Schurr J, Schwarzinger B, Schwarzinger C, Brameshuber M, W… · 2019-07-19
cited 9× open access unreviewed -
6
Update on glycerol-3-phosphate acyltransferases: the roles in the development of insulin resistance.
Yu J, Loh K, Song ZY, Yang HQ, Zhang Y, Lin S. · 2018-05-25
cited 86× open access unreviewed -
7
Macrophage-Associated Lipin-1 Enzymatic Activity Contributes to Modified Low-Density Lipoprotein-Induced Proinflammatory Signaling and Atherosclerosis.
Vozenilek AE, Navratil AR, Green JM, Coleman DT, Blackburn CMR, Finney AC, Pearson BH, Chrast R, Finck BN, Kl… · 2017-12-07
cited 31× unreviewed -
8
Lipin-1 regulation of phospholipid synthesis maintains endoplasmic reticulum homeostasis and is critical for triple-negative breast cancer cell survival.
He J, Zhang F, Tay LWR, Boroda S, Nian W, Levental KR, Levental I, Harris TE, Chang JT, Du G. · 2017-03-27
cited 51× unreviewed -
9
Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta.
Kanost MR, Arrese EL, Cao X, Chen YR, Chellapilla S, Goldsmith MR, Grosse-Wilde E, Heckel DG, Herndon N, Jian… · 2016-08-12
cited 129× unreviewed -
10
Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites.
Pol A, Gross SP, Parton RG. · 2014-03-01
cited 358× open access unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.