What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
dADP, dGDP, dCDP, or dUDP → corresponding dNTP
Converts dADP dGDP dCDP dUDP into dATP dGTP dCTP dUTP
› Notes
NDPK catalyzes dNDP + ATP (or another NTP) ⇌ dNTP + ADP. This near-equilibrium phosphotransfer uses a phosphohistidine intermediate and supplies dATP, dGTP, dCTP, and dUTP from the RNR products.
dTDP → dTTP
› Notes
NDPK catalyzes dTDP + ATP (or another NTP) ⇌ dTTP + ADP. dTTP then participates in DNA polymerization and also serves as an allosteric specificity effector for RNR and an inhibitor of dCMP deaminase.
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
UDP → UTP
› Notes
Nucleoside diphosphate kinase (NDPK/NME) catalyzes UDP + ATP (or another NTP) ⇌ UTP + ADP (or the corresponding NDP). A phosphohistidine enzyme intermediate mediates phosphoryl transfer; the reaction is near equilibrium.
dUDP → dUTP → dUMP
› Notes
NDPK can phosphorylate dUDP + ATP ⇌ dUTP + ADP, and dUTPase then catalyzes dUTP + H2O → dUMP + PPi. dUTPase is essential because it both supplies dUMP and keeps dUTP low enough to prevent uracil incorporation into DNA.
Showing all 4 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
Europe PMC · fetched just now · sorted by publication date
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1
Chemoproteomics identifies STAT3 as a key target of baicalin in ameliorating liver fibrosis.
Yuan S, Zhou YF, Ma B, Liu Y, Zhang J, Wang Y, Xiao W, Liu H, Wang F, Yu A, Yang W, Wang C. · 2026-02-16
open access unreviewed -
2
Nucleoside Diphosphate Kinase Family: Evolutionary Analysis and Protective Role in Mitochondrial ROS Production.
Jardim-Messeder D, de Souza-Vieira Y, Felix-Cordeiro T, Corrêa RL, Sachetto-Martins G. · 2026-04-09
open access unreviewed -
3
Dentofacial Malocclusion and Salivary Biomarkers in Asthmatic Patients: A Scoping Review.
Raghavan S, Alhaija ESA, Almashraqi AA. · 2026-02-25
open access unreviewed -
4
Proteome Analysis of Nasolacrimal Duct Lavage Fluid in Patients with Primary Acquired Nasolacrimal Duct Obstruction.
You H, Bang W, Kang B, Back S, Park J, Ju M, Park JM, Lew H. · 2026-03-12
open access unreviewed -
5
Proangiogenic Properties of Extracellular Vesicles Secreted by Endothelial Cells Reversibly Primed for Anoikis: A Possible Autocrine Mechanism Induced by Astrocytoma Extracellular Matrix.
Silva-de-Barros AOD, Alves TR, Ribeiro-Fernandes L, Helal-Neto E, Frony AC, Pontes B, Viana NB, Barreira PK, … · 2026-03-11
open access unreviewed -
6
Pharmacological evaluation of an ex vivo cervicovaginal HIV prevention model.
Collins LB, Le A, Nicol MR. · 2026-03-01
open access unreviewed -
7
Genome Imputation for Genome-Wide Association Study of Reproductive Traits in Chinese Duroc, Landrace, and Yorkshire Pigs: Strategy and Validation.
Zhou J, Fu Y, Zhang Y, Tu W, Huang J, Liang Y, Li B, Zhang H, Liu Y, Wang K, Wang H, Tan Y. · 2026-02-12
open access unreviewed -
8
Lactylation fuels nucleotide biosynthesis and facilitates deuterium metabolic imaging of tumor proliferation in preclinical models of H3K27M-mutant gliomas.
Batsios G, Taglang C, Udutha S, Gillespie AM, Phoenix T, Mueller S, Venneti S, Koschmann C, Viswanath P. · 2026-02-11
cited 3× unreviewed -
9
Proteomics landscape of early T-cell precursor acute lymphoblastic leukemia reveals deficient oxidative phosphorylation signatures.
Liu M, Chen T, Lin X, Wu B, Shi F, Liu J, Chen Y, Zeng T, Hou S, Pan Q, Wang X, Yao Y, Yang W, Zhang Y, Huang… · 2026-02-03
open access unreviewed -
10
The Potential Molecular Mechanisms and Key Genes of Early Deterioration of Parenchymal Lesions in Cerebral Venous Sinus Thrombosis.
Cen G, Li J, Wang J, Chen Y, Liang Z. · 2026-01-01
unreviewed
External claims. These come from an index outside this database and are not checked against it. Treat them as leads.