What it does, reaction by reaction
Deoxyribonucleotide Formation (Ribonucleotide Reductase pathway and thymidylate synthesis) Nucleotide Metabolism · Cytosol
dADP, dGDP, dCDP, or dUDP → corresponding dNTP
Converts dADP dGDP dCDP dUDP into dATP dGTP dCTP dUTP
› Notes
NDPK catalyzes dNDP + ATP (or another NTP) ⇌ dNTP + ADP. This near-equilibrium phosphotransfer uses a phosphohistidine intermediate and supplies dATP, dGTP, dCTP, and dUTP from the RNR products.
dTDP → dTTP
› Notes
NDPK catalyzes dTDP + ATP (or another NTP) ⇌ dTTP + ADP. dTTP then participates in DNA polymerization and also serves as an allosteric specificity effector for RNR and an inhibitor of dCMP deaminase.
Pyrimidine De Novo Synthesis (through to UMP, then CTP/dTMP) Nucleotide Metabolism · Cytosol (one mitochondrial step)
UDP → UTP
› Notes
Nucleoside diphosphate kinase (NDPK/NME) catalyzes UDP + ATP (or another NTP) ⇌ UTP + ADP (or the corresponding NDP). A phosphohistidine enzyme intermediate mediates phosphoryl transfer; the reaction is near equilibrium.
dUDP → dUTP → dUMP
› Notes
NDPK can phosphorylate dUDP + ATP ⇌ dUTP + ADP, and dUTPase then catalyzes dUTP + H2O → dUMP + PPi. dUTPase is essential because it both supplies dUMP and keeps dUTP low enough to prevent uracil incorporation into DNA.
Showing all 4 reactions.
What accelerates and inhibits it
Regulation is pathway-specific, so each context is listed separately
No regulation recorded for this enzyme in the source documents.
Recent literature
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